Dimethyl Sulfoxide (DMSO) in Trauma and Disease

Jacob, Stanley W.; Torre, Jack C. de la

doi:10.1201/b18275

Cited by 28 publications

(27 citation statements)

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“…The effect of DMSO + FDP on visuo-spatial memory improvement and the loss of this effect after discontinuation of therapy on week 16, suggests a drug cause and effect. [139,140] These findings also indicate that in order to maintain memory improvement during induced-brain hypoperfusion, this drug combination (and possibly most other similar remedies) must be given on a chronic basis.…”

Section: Dimethyl Sulfoxidementioning

confidence: 91%

“…[139] Dimethyl sulfoxide (DMSO) was combined with the glycolytic intermediate fructose 1,6-diphosphate ((FDP) and administered orally to cerebral hypoperfused rats from weeks 15 to16 following carotid occlusion. [139] The rationale for using this drug combination is due to DMSO's ability to scavenge circulating free radicals and increase cerebral blood flow, thus counteracting induced hypoperfusion [140] and by FDP to act as an intermediate of anaerobic glycolytic metabolism thereby restoring oxidative phosphorylation and increasing the brain cell energy fuel ATP when administered during prolonged hypoperfusion states. [140,141] The results of this study indicated that daily oral administration of DMSO + FDP but not either drug alone, is an effective treatment for improving ischemic-induced visuo-spatial 19 memory impairment in aging rats.…”

Section: Dimethyl Sulfoxidementioning

confidence: 99%

“…[139] The rationale for using this drug combination is due to DMSO's ability to scavenge circulating free radicals and increase cerebral blood flow, thus counteracting induced hypoperfusion [140] and by FDP to act as an intermediate of anaerobic glycolytic metabolism thereby restoring oxidative phosphorylation and increasing the brain cell energy fuel ATP when administered during prolonged hypoperfusion states. [140,141] The results of this study indicated that daily oral administration of DMSO + FDP but not either drug alone, is an effective treatment for improving ischemic-induced visuo-spatial 19 memory impairment in aging rats. The effect of DMSO + FDP on visuo-spatial memory improvement and the loss of this effect after discontinuation of therapy on week 16, suggests a drug cause and effect.…”

Section: Dimethyl Sulfoxidementioning

confidence: 99%

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Cerebral Perfusion Enhancing Interventions: A New Strategy for the Prevention of Alzheimer Dementia

Torre

2016

Brain Pathology

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Cardiovascular and cerebrovascular diseases are major risk factors in the development of cognitive impairment and Alzheimer's disease (AD). These cardio-cerebral disorders promote a variety of vascular risk factors which in the presence of advancing age are prone to markedly reduce cerebral perfusion and create a neuronal energy crisis. Long-term hypoperfusion of the brain evolves mainly from cardiac structural pathology and brain vascular insufficiency. Brain hypoperfusion in the elderly is strongly associated with the development of mild cognitive impairment (MCI) and both conditions are presumed to be precursors of Alzheimer dementia. A therapeutic target to prevent or treat MCI and consequently reduce the incidence of AD aims to elevate cerebral perfusion using novel pharmacological agents. As reviewed here, the experimental pharmaca include the use of Rho kinase inhibitors, neurometabolic energy boosters, sirtuins and vascular growth factors. In addition, a compelling new technique in laser medicine called photobiomodulation is reviewed. Photobiomodulation is based on the use of low level laser therapy to stimulate mitochondrial energy production non-invasively in nerve cells. The use of novel pharmaca and photobiomodulation may become important tools in the treatment or prevention of cognitive decline that can lead to dementia.

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Section: Dimethyl Sulfoxidementioning

confidence: 91%

Section: Dimethyl Sulfoxidementioning

confidence: 99%

Section: Dimethyl Sulfoxidementioning

confidence: 99%

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Cerebral Perfusion Enhancing Interventions: A New Strategy for the Prevention of Alzheimer Dementia

Torre

2016

Brain Pathology

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“…We used acetone/DMSO at ratio of 3:1 v/v. The volume of DMSO per tablet was approximately 31 µl equivalent to 34.1 mg which is considered a very small volume/quantity in respect to DMSO human toxicity (Brobyn, 1975;Jacob and Jack, 2015).…”

Section: Materials For Printing Of Multi-active Tabletsmentioning

confidence: 99%

3D printing of tablets containing multiple drugs with defined release profiles

Khaled

Burley

Alexander

et al. 2015

International Journal of Pharmaceutics

429

191

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“…Except of relatively toxic dimethyl sulfoxide vehicle [13], to this time no safe and effective enhancers have been proposed for drug delivery to the SC.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide

Kamalov

Lavrov

Yergeshov

et al. 2016

Colloids and Surfaces B: Biointerfaces

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In this study the effect of oxidative modification on micellar and drug deliveryproperties of copolymers of ethylene oxide (EO) and propylene oxide (PO) wasinvestigated. Carboxylated trifunctional copolymers were synthesized in the reaction withchromium oxide (VI). We found that carboxylation significantly improved the uniformityand stability of polymeric micelles by inhibiting the microphase transition. Thecytotoxicity of copolymers was studied in relation to their aggregative state on two celltypes (cancer line vs. primary fibroblasts). The accumulation of rhodamine 123 inneuroblastoma SH-SY5Y cells was dramatically increased in the presence of the oxidizedblock copolymer with the number of PO and EO units of 83.5 and 24.2, respectively. Thecopolymer was also tested as an enhancer for topical drug delivery to the spinal cordwhen applied subdurally. The oxidized copolymer facilitated the penetration ofrhodamine 123 across spinal cord tissues and increased its intraspinal accumulation.These results show the potential of using oxidized EO/PO based polymers for noninvasivedelivery of protective drugs after spinal cord injury

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Dimethyl Sulfoxide (DMSO) in Trauma and Disease

Cited by 28 publications

References 0 publications

Cerebral Perfusion Enhancing Interventions: A New Strategy for the Prevention of Alzheimer Dementia

Cerebral Perfusion Enhancing Interventions: A New Strategy for the Prevention of Alzheimer Dementia

3D printing of tablets containing multiple drugs with defined release profiles

Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide

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