Dimethyl-Sulfoxide-Free Cell Cryoprotectant Derived from Amino Acids
Xi Chen,
Taijie Zhan,
Yuting Wang
et al.
Abstract:With the large-scale applications of cryopreservation technology in the cell therapy fields, traditional permeable cryoprotectants (CPAs) have led to serious issues, such as cell cycle arrest, inhibition of cell proliferation and differentiation, apoptosis, altered gene expression, etc. Development of green, non-toxic cryoprotectants is critically needed. Amino acids could serve as substrates for protein and cellular metabolism and as cryoprotectants with non-toxicity, balancing the intracellular water osmotic… Show more
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