Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice

Shi, Xiaojian; Luo, Xueting; Xu, Xin

doi:10.5582/bst.2019.01351

Cited by 6 publications

(1 citation statement)

References 36 publications

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“…Interestingly, exercise training is believed to promote muscle regeneration after injuries [ 48 ]. We previously observed that swimming for 8 weeks increases myocardial DDAH1 expression and promotes cardiac angiogenesis in mice [ 49 ]. Moreover, a recent study showed that exercise induced DDAH1 upregulation in bones through enhancing the binding capacity between TAZ and SMAD4 [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

DDAH1 Protects against Cardiotoxin-Induced Muscle Injury and Regeneration

Feng,

Cui,

Fang

et al. 2023

Antioxidants

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Nitric oxide (NO) is an important biological signaling molecule affecting muscle regeneration. The activity of NO synthase (NOS) is regulated by dimethylarginine dimethylaminohydrolase 1 (DDAH1) through degradation of the endogenous NOS inhibitor asymmetric dimethylarginine (ADMA). To investigate the role of DDAH1 in muscle injury and regeneration, muscle-specific Ddah1-knockout mice (Ddah1MKO) and their littermates (Ddah1f/f) were used to examine the progress of cardiotoxin (CTX)-induced muscle injury and subsequent muscle regeneration. After CTX injection, Ddah1MKO mice developed more severe muscle injury than Ddah1f/f mice. Muscle regeneration was also delayed in Ddah1MKO mice on Day 5 after CTX injection. These phenomena were associated with higher serum ADMA and LDH levels as well as a great induction of inflammatory response, oxidative stress and cell apoptosis in the gastrocnemius (GA) muscle of Ddah1MKO mice. In the GA muscle of CTX-treated mice, Ddah1 deficiency decreased the protein expression of M-cadherin, myogenin, Bcl-2, peroxiredoxin 3 (PRDX3) and PRDX5, and increased the protein expression of MyoD, TNFα, Il-6, iNOS and Bax. In summary, our data suggest that DDAH1 exerts a protective role in muscle injury and regeneration.

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Section: Discussionmentioning

confidence: 99%