Dimethylarginines in patients with type 2 diabetes mellitus: Relation with the glycaemic control

Can, Ayten; Bekpınar, Seldağ; Gürdöl, Figen; Tütüncü, Yıldız; Ünlüçerçi, Yeşim; Dınççağ, Nevin

doi:10.1016/j.diabres.2011.08.008

Cited by 22 publications

(19 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ADMA has been implicated in the endothelial dysfunction accompanying a broad range of clinical disorders such as obesity, cardiovascular disease, chronic renal failure, diabetes and hypertension [7][8][9]. Indeed, a significant increase in plasma ADMA concentration has been reported in individuals with impaired glucose tolerance [10], diabetes [11] and in the overweight, in whom weight loss was associated with a reduction in ADMA and improved markers of insulin sensitivity [10]. It is of interest that, in patients with acute illness, increased ADMA concentration has been associated with increased mortality and several studies have reported ADMA concentration as an independent risk factor for adverse outcomes in patients with critical illness.…”

Section: Introductionmentioning

confidence: 99%

Assessment of asymmetrical dimethylarginine metabolism in patients with critical illness

Ghashut

Blackwell

Ryan

et al. 2017

Eur J Clin Investigation

View full text Add to dashboard Cite

Background: Critically ill patients experience metabolic disorders including hypercatabolic state and hyperglycaemia and these are associated with poor outcome. Hyperglycaemia and asymmetric dimethylarginine (ADMA) are reported to have significant influences on endothelial dysfunction. The aim of the present study was to examine the relationship between plasma asymmetric dimethylarginine (ADMA) and related arginine metabolism in patients with critical illness.

show abstract

Section: Introductionmentioning

confidence: 99%

Assessment of asymmetrical dimethylarginine metabolism in patients with critical illness

Ghashut

Blackwell

Ryan

et al. 2017

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…Although ADMA plasma levels were reported to be elevated in patients with type 2 diabetes (2) and insulin resistance (3), there are discrepancies concerning the association of ADMA with glycemic control and its prognostic value regarding CV disease (CVD) in diabetes patients (4)(5)(6)(7)(8). Results from prospective studies reporting that high levels of ADMA predicted CV events in patients with diabetes mellitus (9,10) could not be confirmed in populationbased prospective cohorts (7).…”

mentioning

confidence: 61%

“…In patients with type 2 diabetes mellitus, SDMA was inversely associated with glycemic control and with insulin resistance in nondiabetic Caucasians (5,16). Furthermore, prospective studies found that SDMA was an independent predictor for mortality in patients with CVD (17,18).…”

mentioning

confidence: 98%

Genetic and Environmental Determinants of Dimethylarginines and Association With Cardiovascular Disease in Patients With Type 2 Diabetes

et al. 2014

View full text Add to dashboard Cite

OBJECTIVETo investigate determinants of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), including single nucleotide polymorphisms (SNPs), in the DDAH1, DDAH2, and AGXT2 genes and their associations with prevalent and incident cardiovascular disease (CVD) in older adults with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODSPrevalent CVD was assessed in men and women aged 60-75 years with type 2 diabetes as part of the Edinburgh Type 2 Diabetes Study (ET2DS), and the participants were prospectively followed up for 4 years for incident CVD. Dimethylarginines were measured in 783 of these subjects, and genotyping for tag SNPs in the DDAH1, DDAH2, and AGXT2 genes was performed in 935 subjects. RESULTSPlasma ADMA levels were significantly associated with SNPs in DDAH1 (top SNP rs1554597; P = 9.0E-09), while SDMA levels were associated with SNPs in AGXT2 (top SNP rs28305; P = 1.3E-04). Significant, independent determinants of plasma ADMA were sex, L-arginine, creatinine, fasting glucose, and rs1554597 (all P < 0.05; combined R 2 = 0.213). Determinants of SDMA were age, sex, creatinine, L-arginine, diabetes duration, prevalent CVD, and rs28305 (all P < 0.05; combined R 2 = 0.425). Neither dimethylarginine was associated with incident CVD. None of the investigated SNPs were associated with overall CVD, although subgroup analysis revealed a significant association of AGXT2 rs28305 with intermittent claudication. CONCLUSIONSOur study in a well-characterized population with type 2 diabetes does not support reported associations or causal relationship between ADMA and features of diabetes or CVD.

show abstract

“…However, a recent study has demonstrated that SDMA concentrations in patients with type 2 diabetes depend on glycaemic control. Can et al observed that patients with relatively poor glycaemic control had lower SDMA concentrations vs. patients with good control and healthy subjects [58]. The presence of a negative correlation between SDMA and both HbA1c and fructosamine suggests an interaction between protein methylation and glucose homeostasis [58].…”

Section: Discussionmentioning

confidence: 99%

Transsulfuration Pathway Thiols and Methylated Arginines: The Hunter Community Study

et al. 2013

View full text Add to dashboard Cite

BackgroundSerum homocysteine, when studied singly, has been reported to be positively associated both with the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine [ADMA, via inhibition of dimethylarginine dimethylaminohydrolase (DDAH) activity] and with symmetric dimethylarginine (SDMA). We investigated combined associations between transsulfuration pathway thiols, including homocysteine, and serum ADMA and SDMA concentrations at population level.MethodsData on clinical and demographic characteristics, medication exposure, C-reactive protein, serum ADMA and SDMA (LC-MS/MS), and thiols (homocysteine, cysteine, taurine, glutamylcysteine, total glutathione, and cysteinylglycine; capillary electrophoresis) were collected from a sample of the Hunter Community Study on human ageing [n = 498, median age (IQR) = 64 (60–70) years].ResultsRegression analysis showed that: a) age (P = 0.001), gender (P = 0.03), lower estimated glomerular filtration rate (eGFR, P = 0.08), body mass index (P = 0.008), treatment with beta-blockers (P = 0.03), homocysteine (P = 0.02), and glutamylcysteine (P = 0.003) were independently associated with higher ADMA concentrations; and b) age (P = 0.001), absence of diabetes (P = 0.001), lower body mass index (P = 0.01), lower eGFR (P<0.001), cysteine (P = 0.007), and glutamylcysteine (P<0.001) were independently associated with higher SDMA concentrations. No significant associations were observed between methylated arginines and either glutathione or taurine concentrations.ConclusionsAfter adjusting for clinical, demographic, biochemical, and pharmacological confounders the combined assessment of transsulfuration pathway thiols shows that glutamylcysteine has the strongest and positive independent associations with ADMA and SDMA. Whether this reflects a direct effect of glutamylcysteine on DDAH activity (for ADMA) and/or cationic amino acid transport requires further investigations.

show abstract

Dimethylarginines in patients with type 2 diabetes mellitus: Relation with the glycaemic control

Cited by 22 publications

References 17 publications

Assessment of asymmetrical dimethylarginine metabolism in patients with critical illness

Assessment of asymmetrical dimethylarginine metabolism in patients with critical illness

Genetic and Environmental Determinants of Dimethylarginines and Association With Cardiovascular Disease in Patients With Type 2 Diabetes

Transsulfuration Pathway Thiols and Methylated Arginines: The Hunter Community Study

Contact Info

Product

Resources

About