Dimethylsulfoniopropionate Promotes Process Outgrowth in Neural Cells and Exerts Protective Effects against Tropodithietic Acid

Wichmann, Heidi; Simon, Meinhard; Richter‐Landsberg, Christiane

doi:10.3390/md14050089

Cited by 15 publications

(12 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dimethylsulfoniopropionate (DMSP) promoted neurite outgrowth and protected against TDA-induced cytotoxicity, involving the upregulation of Hsp32 and activation of the extracellular signal-regulated kinases 1/2 (ERK1/2) [ 149 ]. Fucoxanthin has shown to exhibit neurite outgrowth activity (15.7–31% of cells to develop neurite outgrowth) at much lower concentrations (0.1–2 μM), in the absence of NGF support, indicating that this marine carotenoid could a potential neurotrophic molecule [ 136 ].…”

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

“…Potentials of tramiprosate against AD and PD have also been reviewed elsewhere [ 28 , 209 , 210 ]. Dimethylsulfoniopropionate protected against tropodithietic acid-induced cytotoxicity in OLN-93 and N2a cells by lowering the activation of ERK1/2 and induction of HSP32 [ 149 ]. Phycoerythrin-derived peptide isolated from Pyropia yezoensis promoted survivability of frontal cortical neuron by activating TrkB receptor-ERK1/2 signaling and attenuating ER stress in rat prefrontal cortex [ 211 ] and attenuated glutamate-induced ER stress and senescence of rat primary hippocampal neurons [ 212 ].…”

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

See 1 more Smart Citation

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

et al. 2020

View full text Add to dashboard Cite

Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated complications after cerebral ischemia and brain injuries. As was evident in various preclinical studies, algal compounds conferred neuroprotection against a wide range of neurotoxic stressors, such as oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP+) and, therefore, hold therapeutic promise for brain disorders. While a significant number of algal compounds with promising neuroprotective capacity have been identified over the last decades, a few of them have had access to clinical trials. However, the recent approval of an algal oligosaccharide, sodium oligomannate, for the treatment of Alzheimer’s disease enlightened the future of marine algae-based drug discovery. In this review, we briefly outline the pathophysiology of neurodegenerative diseases and brain injuries for identifying the targets of pharmacological intervention, and then review the literature on the neuroprotective potentials of algal compounds along with the underlying pharmacological mechanism, and present an appraisal on the recent therapeutic advances. We also propose a rational strategy to facilitate algal metabolites-based drug development.

show abstract

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Recent studies remarkably showed that the cytotoxic effects of 15 against eukaryotic cells are dampened by 22 (produced, e. g., by corals and algae), suggesting that it may not only serve as food for bacteria but also to protect the hosts themselves from their 15-synthesizing microbial symbionts (see also Section 5.1.2.). [106] In the following sections, we will highlight studies that imply a potential role of 15 in mutualistic symbiotic relationships.…”

Section: Tropodithietic Acid Producers Host Organisms and Symbioticmentioning

confidence: 99%

“…[141] A later study by the same group remarkably showed that 22 is likely anti-oxidative and protects cells to some extent against the toxic effects of 15. [106] As dimethyl sulfone (that is structurally similar to 22) can cross the blood-brain barrier and because up to 5 mg/mL of 22 showed no cytotoxicity against eukaryotic cells but rather acted neuroprotective in rodents, [142] it may be worthwhile to further study the effects of 22 in combination with 15. It would be interesting to see if, for example, if 15 still maintains anti-cancer and/or antimicrobial activity in presence of 22 (also from an ecological perspective regarding symbiotic relationships of 15-producing bacteria with 22-generating marine invertebrates and algae, see 4.2).…”

Section: Toxicity Of Tropodithietic Acid and Protective Effects Of Dmspmentioning

confidence: 99%

Bacterial Tropone Natural Products and Derivatives: Overview of their Biosynthesis, Bioactivities, Ecological Role and Biotechnological Potential

et al. 2020

View full text Add to dashboard Cite

Tropone natural products are non‐benzene aromatic compounds of significant ecological and pharmaceutical interest. Herein, we highlight current knowledge on bacterial tropones and their derivatives such as tropolones, tropodithietic acid, and roseobacticides. Their unusual biosynthesis depends on a universal CoA‐bound precursor featuring a seven‐membered carbon ring as backbone, which is generated by a side reaction of the phenylacetic acid catabolic pathway. Enzymes encoded by separate gene clusters then further modify this key intermediate by oxidation, CoA‐release, or incorporation of sulfur among other reactions. Tropones play important roles in the terrestrial and marine environment where they act as antibiotics, algaecides, or quorum sensing signals, while their bacterial producers are often involved in symbiotic interactions with plants and marine invertebrates (e. g., algae, corals, sponges, or mollusks). Because of their potent bioactivities and of slowly developing bacterial resistance, tropones and their derivatives hold great promise for biomedical or biotechnological applications, for instance as antibiotics in (shell)fish aquaculture.

show abstract

“…The switch between mutualism and parasitism in algaebacteria interactions has also been found in the interaction between the dinoflagellate Prorocentrum minimum and Dinoroseobacter shibae 2015a,b). It was suggested that D. shibae obtains its energy by degradation of polyhydroxyalkanoate and dimethylsulfoniopropionate (DMSP) , pathways that are also present in P. inhibens (Dickschat et al, 2010;Kanehisa et al, 2016) and with the latter molecule actually preventing the effect of TDA (Wichmann et al, 2016). Additionally, E. huxleyi is a known producer of DMSP (Wolfe and Steinke, 1996;Steinke et al, 2007).…”

Section: Bacterial-microalgal Co-cultivationmentioning

confidence: 99%

Phylogenetic distribution of roseobacticides in the Roseobacter group and their effect on microalgae

Sonnenschein

Phippen

Bentzon-Tilia

et al. 2018

Environ Microbiol Rep

View full text Add to dashboard Cite

The Roseobacter-group species Phaeobacter inhibens produces the antibacterial tropodithietic acid (TDA) and the algaecidal roseobacticides with both compound classes sharing part of the same biosynthetic pathway. The purpose of this study was to investigate the production of roseobacticides more broadly in TDA-producing roseobacters and to compare the effect of producers and non-producers on microalgae. Of 33 roseobacters analyzed, roseobacticide production was a unique feature of TDA-producing P. inhibens, P. gallaeciensis and P. piscinae strains. One TDA-producing Phaeobacter, 27-4, did not produce roseobacticides, possibly due to a transposable element. TDA-producing Ruegeria and Pseudovibrio did not produce roseobacticides. Addition of roseobacticide-containing bacterial extracts affected the growth of the microalgae Rhodomonas salina, Thalassiosira pseudonana and Emiliania huxleyi, while growth of Tetraselmis suecica was unaffected. During co-cultivation, growth of E. huxleyi was initially stimulated by the roseobacticide producer DSM 17395, while the subsequent decline in algal cell numbers during senescence was enhanced. Strain 27-4 that does not produce roseobacticides had no effect on algal growth. Both bacterial strains, DSM 17395 and 27-4, grew during co-cultivation presumably utilizing algal exudates. Furthermore, TDA-producing roseobacters have potential as probiotics in marine larviculture and it is promising that the live feed Tetraselmis was unaffected by roseobacticides-containing extracts.

show abstract

Dimethylsulfoniopropionate Promotes Process Outgrowth in Neural Cells and Exerts Protective Effects against Tropodithietic Acid

Cited by 15 publications

References 56 publications

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Bacterial Tropone Natural Products and Derivatives: Overview of their Biosynthesis, Bioactivities, Ecological Role and Biotechnological Potential

Phylogenetic distribution of roseobacticides in the Roseobacter group and their effect on microalgae

Contact Info

Product

Resources

About