Diminished Cold Avoidance Behaviours after Chronic Cold Exposure – Potential Involvement of TRPM8

Ezzatpanah, Somayeh; Eriksen, Mina Baarnes; Moe, Anne-Mari Gjestvang; Haugen, Fred

doi:10.1016/j.neuroscience.2021.06.014

Cited by 5 publications

(3 citation statements)

References 67 publications

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“…Scientific interest has been emerging on how thermal stimuli serve as natural reinforcers for learning and behavioral adaptation. For instance, exposure to thermally noxious environments (i.e., with significantly cold or hot temperatures) typically elicits escape and avoidance behavior, whereas exposure to thermally pleasant or neutral environments (i.e., with temperatures closer to body core levels) typically promotes approach and seeking behavior ( Wessnitzer et al, 2008 ; Ofstad et al, 2011 ; Ezzatpanah et al, 2021 ; Kanai et al, 2022 ). While these observations have been often emphasized from the standpoint of thermoregulatory behavior ( Bokiniec et al, 2018 ; Nakamura, 2018 ), how thermal reinforcers serve for deeming environments as threatening or safe remains unexploited.…”

Section: Introductionmentioning

confidence: 99%

“…typically promotes approach and seeking behavior (Ezzatpanah et al, 2021;Kanai et al, 2022;Ofstad et al, 2011;Wessnitzer et al, 2008). While these observations have been often emphasized from the standpoint of thermoregulatory behavior (Bokiniec et al, 2018;Nakamura, 2018), how thermal reinforcers serves for deeming environments as threatening or safe remains unexploited.…”

Section: Introductionmentioning

confidence: 99%

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Prefrontal Regulation of Safety Learning during Ethologically Relevant Thermal Threat

Felix-Ortiz,

Terrell,

Gonzalez

et al. 2024

eNeuro

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Learning and adaptation during sources of threat and safety are critical mechanisms for survival. The prelimbic (PL) and infralimbic (IL) subregions of the medial prefrontal cortex (mPFC) have been broadly implicated in the processing of threat and safety. However, how these regions regulate threat and safety during naturalistic conditions involving thermal challenge still remains elusive. To examine this issue, we developed a novel paradigm in which adult mice learned that a particular zone that was identified with visuospatial cues was associated with either a noxious cold temperature (“threat zone”) or a pleasant warm temperature (“safety zone”). This led to the rapid development of avoidance behavior when the zone was paired with cold threat or approach behavior when the zone was paired with warm safety. During a long-term test without further thermal reinforcement, mice continued to exhibit robust avoidance or approach to the zone of interest, indicating that enduring spatial-based memories were formed to represent the thermal threat and thermal safety zones. Optogenetic experiments revealed that neural activity in PL and IL was not essential for establishing the memory for the threat zone. However, PL and IL activity bidirectionally regulated memory formation for the safety zone. While IL activity promoted safety memory during normal conditions, PL activity suppressed safety memory especially after a stress pre-treatment. Therefore, a working model is proposed in which balanced activity between PL and IL is favorable for safety memory formation, whereas unbalanced activity between these brain regions is detrimental for safety memory after stress.Significance StatementThis study provides new insights on the role of prefrontal cortical processing for threat and safety learning during thermal challenge. For this, a novel behavioral paradigm was implemented in which laboratory mice learned that a particular spatial zone was associated with either a noxious cold temperature (“thermal threat”) or a pleasant warm temperature (“thermal safety”). Manipulations of neuronal activity revealed that the prelimbic and infralimbic subregions of the medial prefrontal cortex bidirectionally regulated memory formation for the thermal safety zone, but not for the thermal threat zone. In addition, the influence of these cortical regions during safety memory formation was altered when mice underwent a stress treatment to produce a disease-like state.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prefrontal Regulation of Safety Learning during Ethologically Relevant Thermal Threat

Felix-Ortiz,

Terrell,

Gonzalez

et al. 2024

eNeuro

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“…These physiological responses decrease heat loss and increase metabolic heat production. Chronic cold exposure evokes NST adaptations in BAT and skeletal muscle, helping to maintain core body temperature and energy homeostasis at low temperatures [15]. The Enshi black pig is an important Chinese indigenous breed.…”

Section: Introductionmentioning

confidence: 99%

The Role of lncRNAs in Pig Muscle in Response to Cold Exposure

Zhang,

Wang,

Wang

et al. 2023

Genes

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Cold exposure is an essential factor affecting breeding efforts in cold regions. Muscle, as an important tissue for homeothermic animals, can produce heat through shivering thermogenesis (ST) and non-shivering thermogenesis (NST) under cold exposure. Long non-coding RNAs (lncRNAs) play important roles in regulating gene expression. However, the regulatory mechanisms of lncRNAs and their role in the thermogenesis of pigs are unclear. We examined lncRNAs in the skeletal muscle of an indigenous pig breed, the Enshi black pig, when the pigs were exposed to acute or chronic cold. Three pigs were maintained inside a pig house (control group), three pigs were maintained outside the pig house for 55 d (chronic cold group), and three pigs were suddenly exposed to the conditions outside the pig house for 3 days (acute cold group). After the experiment, the longissimus dorsi of each pig were collected, and their lncRNA profiles were sequenced and analyzed. Each sample obtained nearly 12.56 Gb of clean data. A total of 11,605 non-coding RNAs were obtained, including 10,802 novel lncRNAs. The number of differentially expressed lncRNAs (DElncRNAs) was identified under acute cold (427) and cold acclimation (376), with 215 and 192 upregulated lncRNAs, respectively. However, only 113 lncRNAs were commonly upregulated by acute cold and cold acclimation. In addition, 65% of the target genes were trans-regulated by DElncRNAs. The target genes were enriched in signal transduction, immune system, cell growth and death pathways, and amino acid and carbohydrate metabolism. Compared to cold acclimation, acute cold stress-induced more DElncRNAs and response pathways. In conclusion, low temperatures altered the expression levels of lncRNAs and their target genes in muscle tissue. Some potential mechanisms were revealed, including ion migration and the metabolism of amino acids and carbohydrates.

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Timing of acute cold exposure determines UCP1 and FGF21 expression - Possible interactions between the thermal environment, thermoregulatory responses, and peripheral clocks

Chau,

Ryan,

Dalen

et al. 2024

Journal of Thermal Biology

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Diminished Cold Avoidance Behaviours after Chronic Cold Exposure – Potential Involvement of TRPM8

Cited by 5 publications

References 67 publications

Prefrontal Regulation of Safety Learning during Ethologically Relevant Thermal Threat

Prefrontal Regulation of Safety Learning during Ethologically Relevant Thermal Threat

The Role of lncRNAs in Pig Muscle in Response to Cold Exposure

Timing of acute cold exposure determines UCP1 and FGF21 expression - Possible interactions between the thermal environment, thermoregulatory responses, and peripheral clocks

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