Diminished effort on a progressive ratio task in both unipolar and bipolar depression

Hershenberg, Rachel; Satterthwaite, Theodore D.; Daldal, Aylin; Katchmar, Natalie; Moore, Tyler M.; Kable, Joseph W.; Wolf, Daniel H.

doi:10.1016/j.jad.2016.02.003

Cited by 132 publications

(99 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We recently demonstrated using task-based fMRI that depression severity is related to blunted VS responses to monetary rewards across unipolar and bipolar depression (6); others have reported similar results across a diverse group of patients with MDD, SCZ, alcohol dependence, ADHD and healthy controls (10). These findings highlight the value of dimensional approaches in identifying common neurobehavioral brain abnormalities (11). …”

Section: Introductionmentioning

confidence: 75%

Common Dimensional Reward Deficits Across Mood and Psychotic Disorders: A Connectome-Wide Association Study

Sharma

Wolf

Ćirić

et al. 2017

AJP

Self Cite

149

View full text Add to dashboard Cite

Objective Anhedonia is central to multiple psychiatric disorders and causes substantial disability. A dimensional conceptualization posits that anhedonia severity relates to a trans-diagnostic continuum of reward deficits in specific neural networks. Prior investigations of functional connectivity related to anhedonia have focused on case-control comparisons in specific disorders, using region-specific seed-based analyses. Here, the authors explore the entire functional connectome in relation to reward responsivity across a population of adults with hetereogenous psychopathology. Method In a sample of 225 adults from five diagnostic groups (major depressive disorder, n=32; bipolar disorder, n=50; schizophrenia, n=51, psychosis risk, n=39; and healthy controls, n=53), the authors conducted a connectome-wide analysis examining the relationship between a dimensional measure of reward responsivity (reward sensitivity subscale of the Behavioral Activation Scale) and resting-state functional connectivity using multivariate distance-based matrix regression. Results This connectome-wide analysis identified foci of dysconnectivity associated with reward responsivity in the nucleus accumbens (NAc), default mode network (DMN) and cingulo-opercular network (CON). Follow-up analyses revealed dysconnectivity among specific large-scale functional networks and their connectivity with the NAc. Reward deficits were associated with decreased connectivity between the NAc and DMN and increased connectivity between the NAc and CON. In addition, impaired reward responsivity was associated with DMN hyper-connectivity and diminished connectivity between DMN and CON. Conclusions These results emphasize the centrality of the nucleus accumbens in the pathophysiology of reward deficits and suggest that dissociable patterns of connectivity among large-scale networks are critical to the neurobiology of reward dysfunction across clinical diagnostic categories.

show abstract

Section: Introductionmentioning

confidence: 75%

Common Dimensional Reward Deficits Across Mood and Psychotic Disorders: A Connectome-Wide Association Study

Sharma

Wolf

Ćirić

et al. 2017

AJP

Self Cite

149

View full text Add to dashboard Cite

show abstract

“…A few other studies have used various non-learning tasks and have suggested that individuals with MDD have low motivation for monetary reward214142; however, in these studies, the focus was also on responses at the outcome phase2223. Unlike the abundant literature about responses to reward outcome (particularly during reward learning), little is known about whether individuals with MDD have intact ability to process and compare values during decision-making when no learning is required.…”

Section: Discussionmentioning

confidence: 99%

Valuation in major depression is intact and stable in a non-learning environment

Chung

Kadlec

Aimone

et al. 2017

Sci Rep

View full text Add to dashboard Cite

The clinical diagnosis and symptoms of major depressive disorder (MDD) have been closely associated with impairments in reward processing. In particular, various studies have shown blunted neural and behavioral responses to the experience of reward in depression. However, little is known about whether depression affects individuals’ valuation of potential rewards during decision-making, independent from reward experience. To address this question, we used a gambling task and a model-based analytic approach to measure two types of individual sensitivity to reward values in participants with MDD: ‘risk preference,’ indicating how objective values are subjectively perceived, and ‘inverse temperature,’ determining the degree to which subjective value differences between options influence participants’ choices. On both of these measures of value sensitivity, participants with MDD were comparable to non-psychiatric controls. In addition, both risk preference and inverse temperature were stable over four laboratory visits and comparable between the groups at each visit. Neither valuation measure varied with severity of clinical symptoms in MDD. These data suggest intact and stable value processing in MDD during risky decision-making.

show abstract

“…Within these patient samples, relationship between reported anhedonic symptoms and effortful performance has been mixed. Several studies have reported expected negative associations between effortful responses and anhedonic symptoms (Hershenberg et al, 2016;Treadway et al, 2012a;Yang et al, 2014), yet in several instances there was either no observed relationship (CleryMelin et al, 2011) or a an unexpected positive relationship between effort and total BDI scores (Treadway et al, 2012a), although further analysis suggests this might be driven by a positive association between self-criticism end effortful performance (Hershenberg et al, 2016). Of these studies, only one study to date has also examined effort-related behavior in patients diagnosed with bipolar disorder (currently depressed), and observed a near identical pattern when compared with unipolar patients (Hershenberg et al, 2016).…”

Section: Reduced Motivation and Psychomotor Function In Psychiatric Dmentioning

confidence: 99%

“…This includes behavioral measures of effort expenditure (Gold et al, 2013;Hartmann et al, 2015;Hershenberg et al, 2016;Treadway et al, 2009;Wolf et al, 2014), affective responses to positive stimuli (Bylsma et al, 2008;Dichter et al, 2010;Gold et al, 2008), and reinforcement learning (Pizzagalli et al, 2008) as well as self-report measures that seek to dissociate aspects of anticipation, motivation and enjoyment (eg, Cooper et al, 2008;Gard et al, 2006).…”

Section: Reduced Motivation and Psychomotor Function In Psychiatric Dmentioning

confidence: 99%

“…In unipolar depression, several studies have found evidence for reduced physical effort expenditure in exchange for monetary rewards (Hershenberg et al, 2016;Treadway et al, 2012a;Yang et al, 2014). In a related effort paradigm using a handgrip apparatus, Clery-Melin et al (2011) observed that patients exerted less physical force than controls and were less responsive to monetary incentives.…”

Section: Reduced Motivation and Psychomotor Function In Psychiatric Dmentioning

confidence: 99%

See 1 more Smart Citation

Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

Felger

Treadway

2016

Neuropsychopharmacol

317

237

View full text Add to dashboard Cite

Motivational and motor deficits are common in patients with depression and other psychiatric disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in motivation and motor function are associated with alterations in corticostriatal neurocircuitry, which may reflect abnormalities in mesolimbic and mesostriatal dopamine (DA). One pathophysiologic pathway that may drive changes in DAergic corticostriatal circuitry is inflammation. Biomarkers of inflammation such as inflammatory cytokines and acute-phase proteins are reliably elevated in a significant proportion of psychiatric patients. A variety of inflammatory stimuli have been found to preferentially target basal ganglia function to lead to impaired motivation and motor activity. Findings have included inflammation-associated reductions in ventral striatal neural responses to reward anticipation, decreased DA and DA metabolites in cerebrospinal fluid, and decreased availability, and release of striatal DA, all of which correlated with symptoms of reduced motivation and/or motor retardation. Importantly, inflammation-associated symptoms are often difficult to treat, and evidence suggests that inflammation may decrease DA synthesis and availability, thus circumventing the efficacy of standard pharmacotherapies. This review will highlight the impact of administration of inflammatory stimuli on the brain in relation to motivation and motor function. Recent data demonstrating similar relationships between increased inflammation and altered DAergic corticostriatal circuitry and behavior in patients with major depressive disorder will also be presented. Finally, we will discuss the mechanisms by which inflammation affects DA neurotransmission and relevance to novel therapeutic strategies to treat reduced motivation and motor symptoms in patients with high inflammation.

show abstract

Diminished effort on a progressive ratio task in both unipolar and bipolar depression

Cited by 132 publications

References 27 publications

Common Dimensional Reward Deficits Across Mood and Psychotic Disorders: A Connectome-Wide Association Study

Common Dimensional Reward Deficits Across Mood and Psychotic Disorders: A Connectome-Wide Association Study

Valuation in major depression is intact and stable in a non-learning environment

Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

Contact Info

Product

Resources

About