Diminished immune responses with aging predispose older adults to common and uncommon influenza complications

Keilich, Spencer R; Bartley, Jenna M.; Haynes, Laura

doi:10.1016/j.cellimm.2019.103992

Cited by 63 publications

(46 citation statements)

References 210 publications

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“… 66 In conclusion, both the innate and the adaptive cellular immune system of the older patient is weakened ( immunosenescence ), with a pro-inflammatory tendency ( inflammaging ), which seems to be intensified during COVID-19, increasing disease severity. 61 , 66 , 67 , 68 …”

Section: Dysfunctional Immune Responsementioning

confidence: 99%

How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity

Smorenberg

Peters

Daele³

et al. 2021

European Journal of Internal Medicine

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Highlights Especially the frail elderly show a high number of severe COVID-19. Viral shedding may be increased in elderly patients. Early identification is complicated due to atypical disease presentation. Applying hygiene measures in patients with cognitive disorders is challenging. The cardiorespiratory reserve is decreased increasing the risk of complications. The aging immune system has a pro-inflammatory tendency, exaggerated by SARS-CoV-2.

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Section: Dysfunctional Immune Responsementioning

confidence: 99%

How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity

Smorenberg

Peters

Daele³

et al. 2021

European Journal of Internal Medicine

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“…Diminished immune responses that accompany aging, a phenotype defined immunosenescence, can predispose the elderly to complications caused by viral infection (Keilich et al, 2019).…”

Section: A Sso Ciati On Of Cellul Ar S Ene Scen Ce With Immune Imbamentioning

confidence: 99%

Cellular senescence as a potential mediator of COVID‐19 severity in the elderly

et al. 2020

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Coronavirus disease 2019 (COVID-19) represents a complex respiratory distress syndrome which can evolve into multi-organ failure caused by the betacoronavirus SARS-CoV-2. Epidemiological data shows that COVID-19 has a rising mortality particularly in males with advanced age. In United States, Europe, and China, individuals over 60 years of age with underlying conditions such as hypertension, diabetes, cardiovascular or respiratory disease, and cancer are considered to be more at risk to develop severe symptoms (Chen

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“…For instance, the vast majority of the mortality associated with both influenza and SARS-CoV-2 infections, occur in people 65 years and older. It has been shown that influenza disease severity is elevated, prolonged, and linked with increased comorbidities and death in the elderly population [19]. In addition to the acute mortality caused by respiratory viral infections, evidence has suggested that survivors of primary viral pneumonia may display persistent impairment of lung function due to lung fibrosis [20].…”

Section: Introductionmentioning

confidence: 99%

Tissue-resident CD8⁺T cells drive age-associated chronic lung sequelae following viral pneumonia

Sun

Goplen

2020

Preprint

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32Lower respiratory viral infections, such as influenza virus and severe acute respiratory syndrome 33 coronavirus 2 (SARS-CoV2) infections, often cause severe viral pneumonia in aged individuals. 34Here, we report that influenza viral pneumonia leads to chronic non-resolving lung pathology 35 and exaggerated accumulation of CD8 + tissue-resident memory T cells (TRM) in the respiratory 36 tract of aged hosts. TRM accumulation relies on elevated TGF-b present in aged tissues. Further, 37we show that TRM isolated from aged lungs lack a subpopulation characterized by expression of 38 molecules involved in TCR signaling and effector function. Consequently, TRM cells from aged 39 lungs were insufficient to provide heterologous protective immunity. Strikingly, the depletion of 40 CD8 + TRM cells dampens persistent chronic lung inflammation and ameliorates tissue fibrosis in 41 aged, but not young, animals. Collectively, our data demonstrate that age-associated TRM cell 42 malfunction supports chronic lung inflammatory and fibrotic sequelae following viral pneumonia 43 in aged hosts. 44 45 46 47 48

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Diminished immune responses with aging predispose older adults to common and uncommon influenza complications

Cited by 63 publications

References 210 publications

How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity

How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity

Cellular senescence as a potential mediator of COVID‐19 severity in the elderly

Tissue-resident CD8⁺T cells drive age-associated chronic lung sequelae following viral pneumonia

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Diminished immune responses with aging predispose older adults to common and uncommon influenza complications

Cited by 63 publications

References 210 publications

How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity

How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity

Cellular senescence as a potential mediator of COVID‐19 severity in the elderly

Tissue-resident CD8+T cells drive age-associated chronic lung sequelae following viral pneumonia

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Product

Resources

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Tissue-resident CD8⁺T cells drive age-associated chronic lung sequelae following viral pneumonia