2024
DOI: 10.1111/bph.17347
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Diminished nuclear‐localized β‐adrenoceptor signalling activates YAP to promote kidney fibrosis in diabetic nephropathy

Wenjing Xiang,
Lei Li,
Manman Qin
et al.

Abstract: Background and PurposeDiabetic nephropathy (DN) is a leading cause of chronic kidney disease (CKD), which is characterized by mesangial matrix expansion that involves dysfunctional mesangial cells (MCs). However, the underlying mechanisms remain unclear. This study aims to delineate the spatiotemporal contribution of adrenergic signalling in diabetic kidney fibrosis to reveal potential therapeutic targets.Experimental ApproachA model of diabetic nephropathy was induced by in db/db mice. Gene expression in kidn… Show more

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