Diminished Ovarian Reserve in Endometriosis: Insights from In Vitro, In Vivo, and Human Studies—A Systematic Review

Abstract

Endometriosis, a prevalent disorder in women of reproductive age, is often associated with undesired infertility. Ovarian reserve, an essential measure of ovarian function that is crucial for maintaining fecundity, is frequently diminished in women with endometriosis. Though the causative relationship between endometriosis and reduced ovarian reserve is not fully understood due to the lack of standardized and precise measurements of ovarian reserve, there is ongoing discussion regarding the impact of interventions for endometriosis on ovarian reserve. Therefore, in this review, we investigate articles that have related keywords and which were also published in recent years. Thereafter, we provide a comprehensive summary of evidence from in vitro, in vivo, and human studies, thereby shedding light on the decreased ovarian reserve in endometriosis. This research consolidates evidence from in vitro, in vivo, and human studies on the diminished ovarian reserve associated with endometriosis, as well as enhances our understanding of whether and how endometriosis, as well as its interventions, contribute to reductions in ovarian reserve. Furthermore, we explore potential strategies to modify existing therapy options that could help prevent diminished ovarian reserve in patients with endometriosis.

High-fat diet-negative impact on female fertility: from mechanisms to protective actions of antioxidant matrices

“…This aspect is significant, as clinical studies have established a connection between the consumption of a HFD in women of reproductive age and the onset of conditions like endometriosis (79)(80)(81)(82)(83) and polycystic ovary syndrome (PCOS) (84)(85)(86)(87). Both of these conditions can result in a diminished ovarian reserve and are among the primary contributors to infertility in women (88,89). This identifies the urgent need to thoroughly study the ways in which HFD affects ovarian resilience and the overall reproductive system in order to identify the most suitable strategies to address it (78).…”

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“…This aspect is significant, as clinical studies have established a connection between the consumption of a HFD in women of reproductive age and the onset of conditions like endometriosis (79)(80)(81)(82)(83) and polycystic ovary syndrome (PCOS) (84)(85)(86)(87). Both of these conditions can result in a diminished ovarian reserve and are among the primary contributors to infertility in women (88,89). This identifies the urgent need to thoroughly study the ways in which HFD affects ovarian resilience and the overall reproductive system in order to identify the most suitable strategies to address it (78).…”