Diminished post-rest potentiation of contractile force in human dilated cardiomyopathy. Functional evidence for alterations in intracellular Ca2+ handling.

Pieske, Burkert; Sütterlin, Melanie; Schmidt‐Schweda, Stephan; Minami, Kitzatomo; Meyer, Markus; Olschewski, Manfred; Holubarsch, Christian; Just, Hanjörg; Hasenfuß, Gerd

doi:10.1172/jci118849

Cited by 174 publications

(148 citation statements)

References 65 publications

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“…Second, and less well understood, is that the processes underlying frequency dependent behavior are geared to provide an increase in contractility, and thus may impact on the temporal resolution via which PRP is achieved. Further evidence in that PRP and FFR are closely linked is found in the studies on failing myocardium, where both PRP [53] and FFR [3,54] seem to be blunted and hallmarks of the contractile phenotype of failing myocardium.…”

Section: Post-rest Potentiation and Extra-systolic Behaviormentioning

confidence: 91%

Determinants of frequency-dependent contraction and relaxation of mammalian myocardium

Janssen

Periasamy

2007

Journal of Molecular and Cellular Cardiology

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Section: Post-rest Potentiation and Extra-systolic Behaviormentioning

confidence: 91%

Determinants of frequency-dependent contraction and relaxation of mammalian myocardium

Janssen

Periasamy

2007

Journal of Molecular and Cellular Cardiology

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“…The active properties of the failing non-infarcted tissue were scaled from human data (Pieske et al, 1996), in which peak myofiber stress was 27% lower than in healthy tissue, and relaxation prolonged by 17%.…”

Section: Mechanical Materials Propertiesmentioning

confidence: 99%

Cardiac resynchronization: Insight from experimental and computational models

Kerckhoffs

Lumens

Vernooy

et al. 2008

Progress in Biophysics and Molecular Biology

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Cardiac resynchronization therapy (CRT) is a promising therapy for heart failure patients with a conduction disturbance, such as left bundle branch block. The aim of CRT is to resynchronize contraction between and within ventricles. However, about 30% of patients do not respond to this therapy. Therefore, a better understanding is needed for the relation between electrical and mechanical activation. In this paper, we focus on to what extent animal experiments and mathematical models can help in order to understand the pathophysiology of asynchrony to further improve CRT.

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“…However, the same authors have reported that cardiomyocytes derived from iPSC exhibited negative force-frequency relationship and lower postrest potentiation than adult cardiac cells [71]. The force-frequency relationship is termed 'positive' when contractility increases as stimulation frequencies are stepped up and 'negative' when increased frequency of stimulation is associated with reduced contraction force [72,73]. Impaired force-frequency relationship is one of the hallmarks of the failing heart [73][74][75].…”

Section: Cardiomyocytes Derived By Differentiation Of Esc and Ipscmentioning

confidence: 99%

“…The force-frequency relationship is termed 'positive' when contractility increases as stimulation frequencies are stepped up and 'negative' when increased frequency of stimulation is associated with reduced contraction force [72,73]. Impaired force-frequency relationship is one of the hallmarks of the failing heart [73][74][75]. Post-rest contractile behaviour of myocardium is an indicator for the capacity of the sarcoplasmic reticulum for storage and release of Ca 2+ .…”

Section: Cardiomyocytes Derived By Differentiation Of Esc and Ipscmentioning

confidence: 99%

We heart cultured hearts. A comparative review of methodologies for targeted differentiation and maintenance of cardiomyocytes derived from pluripotent and multipotent stem cells

Arabadjiev¹,

Petkova²,

Chakarov³

et al. 2014

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Citation: Arabadjiev A, Petkova R, Chakarov S, Pankov R, Zhelev N. We heart cultured hearts. A comparative review of methodologies for targeted differentiation and maintenance of cardiomyocytes derived from pluripotent and multipotent stem cells. AbstractHuman cell lines, including disease cell lines are often superior to routine animal models for the purposes of rapid and safe assessment of the effects of different agents that may modulate myocardial functioning under physiological and pathological conditions. There are several currently existing methodologies for derivation of cardiomyocyte-like cells by targeted differentiation from pluripotent cells and by reprogramming/ transdifferentiation from other types of cells (multipotent progenitors, somatic cells, etc). The present paper reviews the potential sources of cells capable of differentiation along the cardiomyocyte lineage; the existing methodologies for targeted differentiation, outlining the specificities of each method; and the markers for differentiation along the mesodermal and the cardiogenic lineage. The yield of robustly beating cells expressing cardio-specific proteins derived by any of the existing methods, however, still rarely exceeds 70-90 %, even with the newly developed approaches for increasing the differentiation capacity. There still is significant variance in the results obtained by different research groups and even between different experiments carried out in the same laboratory, with the same type of cells and same general type of protocol. Derivation of new lines of human pluripotent and multipotent stem cells according to standardised protocols and in completely defined; xeno-free conditions may increase the reliability and reproducibility of research and speed up the development of potential clinical applications.

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Diminished post-rest potentiation of contractile force in human dilated cardiomyopathy. Functional evidence for alterations in intracellular Ca2+ handling.

Abstract: Post-rest contractile behavior of isolated myocardium indicates the capacity of the sarcoplasmic reticulum (SR) to store and release Ca 2 ϩ . We investigated post-rest behavior in isolated muscle strips from nonfailing (

Cited by 174 publications

References 65 publications

Determinants of frequency-dependent contraction and relaxation of mammalian myocardium

Determinants of frequency-dependent contraction and relaxation of mammalian myocardium

Cardiac resynchronization: Insight from experimental and computational models

We heart cultured hearts. A comparative review of methodologies for targeted differentiation and maintenance of cardiomyocytes derived from pluripotent and multipotent stem cells

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