Diminished vitamin B<sub>12</sub> levels in patients with severe sickle cell disease

Al-Momen, Abdul Kareem

doi:10.1111/j.1365-2796.1995.tb00884.x

Cited by 20 publications

(18 citation statements)

References 23 publications

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“…For the most part, studies have found that patients with SCD are not at a greater risk of suboptimal vitamin B12 status . However, one study on adults with SCD found an increased risk of B12 deficiency . Three of the four studies that found no increased risk of suboptimal B12 status were on children with SCD, while the one that did find an increased risk was on adults.…”

Section: Discussionmentioning

confidence: 96%

Nutrient Insufficiencies/Deficiencies in Children With Sickle Cell Disease and Its Association With Increased Disease Severity

Martyres

Vijenthira

Barrowman

et al. 2016

Pediatric Blood & Cancer

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Our findings show that patients with SCD commonly have multiple nutrient insufficiencies/deficiencies and support the growing evidence for the link between low zinc and increased VOC. It also indicates that increased nutrient insufficiencies/deficiencies are associated with increased disease severity in SCD. Prospective studies with larger samples are needed to further elucidate the relationship between nutrient deficiencies and SCD, and to determine whether nutrient supplementation can improve the disease course.

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Section: Discussionmentioning

confidence: 96%

Nutrient Insufficiencies/Deficiencies in Children With Sickle Cell Disease and Its Association With Increased Disease Severity

Martyres

Vijenthira

Barrowman

et al. 2016

Pediatric Blood & Cancer

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show abstract

“…Some workers have also reported low serum vitamin B 12 levels in sickle cell disease patients; the reason for this is uncertain ( Al‐Momen 1995). While nitrous oxide is not known to reduce vitamin B 12 , patients with sickle cell disease and reduced vitamin B 12 may be unduly prone to the toxic complications of nitrous oxide analgesia.…”

Section: Discussionmentioning

confidence: 99%

Sickle cell disease and nitrous oxide-induced neuropathy

Ogundipe¹,

Walker

Tc³

et al. 1999

Clinical &Amp; Laboratory Haematology

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We report three cases of peripheral neuropathy in patients with sickle cell disease. All had a history of frequent painful crises and regular attendance at our Accident and Emergency department where nitrous oxide analgesia was administered for prolonged periods. All three patients (one male and two females) presented with difficulty in walking associated with paraesthesiae, and neurological examination revealed signs compatible with a peripheral sensorimotor neuropathy, later confirmed by nerve conduction studies. Serum vitamin B12 levels were mildly reduced in two patients and very low in one patient (< 10 ng/l). Haemoglobin levels in all the patients were unchanged compared with their steady-state levels but one had developed a macrocytosis (103 fl). Schilling tests were normal in two patients, and two patients had negative gastric parietal antibodies. All three patients were given intramuscular vitamin B12 in addition to avoiding further exposure to nitrous oxide, and their neurological symptoms improved completely. As nitrous oxide is known to cause a neuropathy similar to that seen in pernicious anaemia, we postulate that nitrous oxide analgesia combined with low B12 levels was the cause of the marked neuropathy in these patients. As a result of our observations and the probable association, we now do not use nitrous oxide analgesia in the management of patients with sickle cell disease.

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“…Patients with severe sickle cell disease may have unrecognized Vit. B12 deficiency [10] . Furthermore, routine folate supplementation in sickle cell anemia prior to determining Vit.B12 status has been considered risky, as it can mask the findings of Vit.B12 deficiency [11] .…”

Section: Discussionmentioning

confidence: 99%

Life threatening vitamin B₁₂deficiency: will timely screening make a difference?

Dharmarajan

Narayanan

Poduval

2000

WJG

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Diminished vitamin B₁₂ levels in patients with severe sickle cell disease

Abstract: We conclude that many patients with severe sickle cell disease may suffer from unrecognized vitamin B12 deficiency.

Cited by 20 publications

References 23 publications

Nutrient Insufficiencies/Deficiencies in Children With Sickle Cell Disease and Its Association With Increased Disease Severity

Nutrient Insufficiencies/Deficiencies in Children With Sickle Cell Disease and Its Association With Increased Disease Severity

Sickle cell disease and nitrous oxide-induced neuropathy

Life threatening vitamin B₁₂deficiency: will timely screening make a difference?

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Diminished vitamin B12 levels in patients with severe sickle cell disease

Abstract: We conclude that many patients with severe sickle cell disease may suffer from unrecognized vitamin B12 deficiency.

Cited by 20 publications

References 23 publications

Nutrient Insufficiencies/Deficiencies in Children With Sickle Cell Disease and Its Association With Increased Disease Severity

Nutrient Insufficiencies/Deficiencies in Children With Sickle Cell Disease and Its Association With Increased Disease Severity

Sickle cell disease and nitrous oxide-induced neuropathy

Life threatening vitamin B12deficiency: will timely screening make a difference?

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Product

Resources

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Diminished vitamin B₁₂ levels in patients with severe sickle cell disease

Life threatening vitamin B₁₂deficiency: will timely screening make a difference?