Diminishing biofilm resistance to antimicrobial nanomaterials through electrolyte screening of electrostatic interactions

Harper, Robert A.; Carpenter, Guy; Proctor, Gordon; Harvey, Richard D.; Gambogi, Robert J.; Geonnotti, Anthony R.; Hider, Robert C.; Jones, Stuart A.

doi:10.1016/j.colsurfb.2018.09.018

Cited by 40 publications

(29 citation statements)

References 55 publications

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“…Results from another in vitro experiment testing strategies to overcome antibiotic resistance mediated by biofilm production revealed that modified vitamin E in form of anionic a-tocopherol phosphate liposomes self-assembled into structures showed antibacterial effects and had the ability to inhibit the growth of Streptococcus oralis. Furthermore, a-tocopherol phosphate cotransmitted with the cationic electrolyte Tris augmented the penetration into oral multi-species biofilms and supported the bactericidal effect of a-tocopherol phosphate [68].…”

Section: Findings From Included Studiesmentioning

confidence: 77%

Vitamin E as promising adjunct treatment option in the combat of infectious diseases caused by bacterial including multi-drug resistant pathogens – Results from a comprehensive literature survey

Hartmann

Mousavi

Bereswill

et al. 2020

EuJMI

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The use of antibiotics has provoked an emergence of various multidrug-resistant (MDR) bacteria. Infectious diseases that cannot be treated sufficiently with conventional antibiotic intervention strategies anymore constitue serious threats to human health. Therefore, current research focus has shifted to alternative, antibiotic-independent therapeutic approaches. In this context, vitamin E constitutes a promising candidate molecule due to its multi-faceted modes of action. Therefore, we used the PubMed database to perform a comprehensive literature survey reviewing studies addressing the antimicrobial properties of vitamin E against bacterial pathogens including MDR bacteria. The included studies published between 2010 and 2020 revealed that given its potent synergistic antimicrobial effects in combination with distinct antibiotic compounds, vitamin E constitutes a promising adjunct antibiotic treatment option directed against infectious diseases caused by MDR bacteria such as Pseudomonas aeruginosa, Burkholderia cenocepacia and methicillin-resistant Staphylococcus aureus (MRSA). In conclusion, the therapeutic value of vitamin E for the treatment of bacterial infections should therefore be investigated in future clinical studies.

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Section: Findings From Included Studiesmentioning

confidence: 77%

Vitamin E as promising adjunct treatment option in the combat of infectious diseases caused by bacterial including multi-drug resistant pathogens – Results from a comprehensive literature survey

Hartmann

Mousavi

Bereswill

et al. 2020

EuJMI

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“…57 The administration of penetration enhancers can be used to modify the interactions between biofilm and nanomaterial. 39 Given that the bacterial cell surface and EPS components are negatively charged (Table S1), cationic penetration enhancers could potentially shield the biofilm charge and as a consequence, increase nanoparticles penetration. Furthermore, the addition of an electrolyte would decrease the Debye length of the EPS functional groups, 58 thus increasing the matrix effective pore size.…”

Section: Msn Interaction With S Aureus Biofilmsmentioning

confidence: 99%

“…For instance, the EPS resistance towards negatively charged nanoparticles could be reduced through electrostatic repulsion by the co-administration of cationic electrolytes. 39 Herein, engineered MSNs with different surface chemistry were evaluated with regards to their entrapment in the biofilm of two S. aureus isolates, whose biofilm matrices differ significantly in composition. The role of the EPS components in nanoparticle-biofilm interactions was examined.…”

Section: Introductionmentioning

confidence: 99%

<p>Tailoring Nanoparticle-Biofilm Interactions to Increase the Efficacy of Antimicrobial Agents Against <em>Staphylococcus aureus</em></p>

Fulaz¹,

Devlin²,

Vitale³

et al. 2020

IJN

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Background: Considering the timeline required for the development of novel antimicrobial drugs, increased attention should be given to repurposing old drugs and improving antimicrobial efficacy, particularly for chronic infections associated with biofilms. Methicillinsusceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) are common causes of biofilm-associated infections but produce different biofilm matrices. MSSA biofilm cells are typically embedded in an extracellular polysaccharide matrix, whereas MRSA biofilms comprise predominantly of surface proteins and extracellular DNA (eDNA). Nanoparticles (NPs) have the potential to enhance the delivery of antimicrobial agents into biofilms. However, the mechanisms which influence the interactions between NPs and the biofilm matrix are not yet fully understood. Methods: To investigate the influence of NPs surface chemistry on vancomycin (VAN) encapsulation and NP entrapment in MRSA and MSSA biofilms, mesoporous silica nanoparticles (MSNs) with different surface functionalization (bare-B, amine-D, carboxyl-C, aromatic-A) were synthesised using an adapted Stöber method. The antibacterial efficacy of VAN-loaded MSNs was assessed against MRSA and MSSA biofilms. Results: The two negatively charged MSNs (MSN-B and MSN-C) showed a higher VAN loading in comparison to the positively charged MSNs (MSN-D and MSN-A). Cellular binding with MSN suspensions (0.25 mg mL −1) correlated with the reduced viability of both MSSA and MRSA biofilm cells. This allowed the administration of low MSNs concentrations while maintaining a high local concentration of the antibiotic surrounding the bacterial cells. Conclusion: Our data suggest that by tailoring the surface functionalization of MSNs, enhanced bacterial cell targeting can be achieved, leading to a novel treatment strategy for biofilm infections.

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“…Furthermore, the cationic nano-polymer totally disintegrated 1 day old biofilms and induced 73% bacterial death at the concentration of 100 µg/ML [46]. In yet another study, Harper et al [47] combined the effects of electrolyte charge screening and anionic (+) alpha-tocopherol phosphate (α-TP) liposome nanoparticles to enhance the diffusion through biofilm of the latter (Figure 3). The bacterial biofilm was grown for 18 h before being treated with the nanoparticles for 2 min.…”

Section: Nanomaterials With Intrinsic Biofilm-eradicating Propertiesmentioning

confidence: 99%

“…The self-assembled 700 nm liposomes had a zeta potential of −20 mV and could not penetrate the oral multispecies oral biofilms (from a donor) in a phosphate (-ve) buffer. In a tris(hydroxymethyl)aminomethane (+ve) buffer, the liposomes were found to penetrate 12.4 ± 3.6 µm into the biofilms and kill the embedded microbes [47].…”

Section: Nanomaterials With Intrinsic Biofilm-eradicating Propertiesmentioning

confidence: 99%

Nanomaterials for Treating Bacterial Biofilms on Implantable Medical Devices

Tran

Booth

et al. 2020

Nanomaterials

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Bacterial biofilms are involved in most device-associated infections and remain a challenge for modern medicine. One major approach to addressing this problem is to prevent the formation of biofilms using novel antimicrobial materials, device surface modification or local drug delivery; however, successful preventive measures are still extremely limited. The other approach is concerned with treating biofilms that have already formed on the devices; this approach is the focus of our manuscript. Treating biofilms associated with medical devices has unique challenges due to the biofilm’s extracellular polymer substance (EPS) and the biofilm bacteria’s resistance to most conventional antimicrobial agents. The treatment is further complicated by the fact that the treatment must be suitable for applying on devices surrounded by host tissue in many cases. Nanomaterials have been extensively investigated for preventing biofilm formation on medical devices, yet their applications in treating bacterial biofilm remains to be further investigated due to the fact that treating the biofilm bacteria and destroying the EPS are much more challenging than preventing adhesion of planktonic bacteria or inhibiting their surface colonization. In this highly focused review, we examined only studies that demonstrated successful EPS destruction and biofilm bacteria killing and provided in-depth description of the nanomaterials and the biofilm eradication efficacy, followed by discussion of key issues in this topic and suggestion for future development.

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Diminishing biofilm resistance to antimicrobial nanomaterials through electrolyte screening of electrostatic interactions

Cited by 40 publications

References 55 publications

Vitamin E as promising adjunct treatment option in the combat of infectious diseases caused by bacterial including multi-drug resistant pathogens – Results from a comprehensive literature survey

Vitamin E as promising adjunct treatment option in the combat of infectious diseases caused by bacterial including multi-drug resistant pathogens – Results from a comprehensive literature survey

<p>Tailoring Nanoparticle-Biofilm Interactions to Increase the Efficacy of Antimicrobial Agents Against <em>Staphylococcus aureus</em></p>

Nanomaterials for Treating Bacterial Biofilms on Implantable Medical Devices

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