Diminution of Arginine Synthetase Activity in Livers of Rats Treated with Testosterone Propionate

Testosterone prevents protein loss via the hepatic urea cycle in human

“…However, the effect of testosterone is not established, and the evidence from animal studies is contradictory. In overiectomized female rats, testosterone treatment for ten days significantly reduced arginine synthetase activity, a key enzymatic component of the urea cycle (27). However, intraperitoneal injection of testosterone into female rats has also been shown to increase liver arginase activity (28).…”