The purpose of this study is to determine the effects of the self-regulation and psychological resilience levels of university students on their academic self-efficacy. The sample of this correlational study included a total of 520 university students enrolled in the Atatürk Faculty of Education at Marmara University. The Self-Regulation Scale, the Brief Resilience Scale, and the Academic Self-Efficacy Scale were used to collect data. It was determined that the psychological resilience levels of the participants varied based on their genders, while their self-regulation and self-efficacy levels did not differ based on the gender variable. Self-regulation and psychological resilience were found to be associated with academic self-efficacy, where self-regulation and psychological resilience together predicted academic self-efficacy.