This document seeks to acknowledge, honor, and shed light on the working conditions of the men and women moving the Mexico‐U.S. truck “rivers of trade.” The truck driver profession constitutes in many countries one of the most dangerous occupations, if not the most. A significant number of injuries and deaths may be attributed to crashes and violence. In many instances, crashes involving trucks can be directly linked to the drivers' working conditions. Pressure from supply chain entities, coercion, low earnings, and generally imbalanced power relations influence drivers to adopt riskier driving behaviors, with poor road safety outcomes. Mexican truck drivers are no exception. The sector is one in which the use of dependent contractors and fleet drivers represented by yellow unions has hampered workers' bargaining power vis‐à‐vis national and transnational corporations. In the first instance, this document will review a number of international road safety and supply chain accountability initiatives putting pressure on stakeholders to act on the matter. Thereafter, it summarizes relevant industry data to better understand the Mexican context. Finally, a decent work approach and analysis will serve as a basis to create a road map of possible actions to improve the working conditions of Mexican truck drivers.