Dinical and Morphological Characteristics of the Skin in Acne Patients in the Course of Treatment With Isotretinoin in the Form of Lidose

Abstract

Objective. To assess clinical and morphological changes in the skin in patients with severe to moderate acne in the course of systemic treatment with isotretinoin in the form of LlDoSE. Materials and methods. The authors conducted a study of the clinical and morphologic state of the skin in 40 patients with severe to moderate acne, who were administered the treatment with systemic retinoids. Previous external therapy was inefficient in 70% of the patients. As many as 45% of the patients developed scars as a result of the regression of acne vulgaris. To visualize the structure of the epidermis, derma and subcutaneous layer, the authors used the ultrasonic skin scanning method at the frequency of 75 M. Results. The skin scanning images obtained as a result demonstrated the possibility of visualizing inflammatory components in the derma, differences in the skin density indices in different facial zones prior to the therapy and reduction in these indices against the background of the systemic therapy with isotretinoin by the third month of the treatment.