Dinuclear phosphorescent rhenium(i) complexes as potential anticancer and photodynamic therapy agents

Abstract

Chemotherapeutic agents that affect lysosomal functions represent a promising strategy for selective tumor therapy and overcoming drug resistance. In this work, two dinuclear phosphorescent rhenium(I) tricarbonyl complexes (DRe1 and DRe2)...

Therapeutic and Diagnostic Applications of Multimetallic Rhenium(I) Tricarbonyl Complexes

“…In compounds 10 and 11 , carboline derivatives were employed as equatorial ligands (Figure 3). [38] Both compounds appeared to localize to lysosomes. Complex 11 was found to cause lysosome damage in A549 cells, owing to its ability to produce reactive oxygen species (ROS) like superoxide (O 2 .− ) and hydrogen peroxide (H 2 O 2 ).…”

Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer Treatments

“…They exhibited significant phototoxicity under blue-light irradiation, producing ROS that resulted in lysosomal damage. The rhenium(I) β-carboline complexes (RE7) had higher 1 O 2 yields under acidic conditions, which are expected to facilitate cancer targeting [100]. The gold(II)/rhenium(I) heterodinuclear complexes (Figure 12:RE8) that have also been produced benefit from the gold delivering increased cytotoxicity to the strongly fluorescent rhenium complexes.…”

“…Table 4. A summary of the IC 50 values, luminescent properties and special features of rhenium(I) luminescent complexes: phosphine ligated complex RE1 [93], GHS-responsive bio-sensing complex RE2 [94], mitochondrial-targeted theragnostic complex RE3 [96], rhenium(I) aqua complex RE5 [98], heterodinuclear Re(I) β-carboline complex RE7 [100], and gold(II)/rhenium(I) heterodinuclear complex RE8 [102]. , GHS-responsive bio-sensing complex RE2 [94], mitochondrial-targeted theragnostic complex RE3 [96], β-carboline rhenium complex RE4 [97], rhenium(I) aqua complex RE5 [98], apoptosis-ferroptosis dual-induction complex RE6 [99], heterodinuclear Re(I) β-carboline complexes RE7 [100], and gold(II)/rhenium(I) heterodinuclear complex RE6 [102].…”

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer†

“…The complexes Dre1 and Dre2 showed a significant photocytotoxicity toward A549 cell lines giving IC 50 values of 0.26 and 0.11µM, respectively, compared to 8.3µM for cisplatin. The authors suggested that these complexes may be used as potential anticancer and PDT agents (138).…”