Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases

Li, Xiaofen; Liu, Sili; Qu, Liping; Yang, Chen; Yuan, Chuqiao; Qin, Anquan; Liang, Jiyi; Huang, Qianqian; Jiang, Miao; Zhou, Wenjun

doi:10.1016/j.jep.2021.114018

Cited by 45 publications

(22 citation statements)

References 111 publications

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“…Di’ao Xinxuekang (DXXK) capsule is the rhizome extract of Dioscorea nipponica Makino and Dioscorea panthaica Prain et Burk and contains dioscin, diosgenin and other steroidal saponins. DXXK is used to prevent and treat coronary heart disease and other associated coronary artery diseases (CADs) ( Qu et al, 2018 ; Li et al, 2021b ). In Traditional Chinese Medicine theory, it has the effects of promoting blood circulation, and removing blood stasis which might explain its therapeutic effect in CADs.…”

Section: Introductionmentioning

confidence: 99%

Di’ao Xinxuekang Capsule Improves the Anti-Atherosclerotic Effect of Atorvastatin by Downregulating the SREBP2/PCSK9 Signalling Pathway

Liang

Liu

et al. 2022

Front. Pharmacol.

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Statins are the first choice for lowering low-density lipoprotein cholesterol (LDL-C) and preventing atherosclerotic cardiovascular disease (ASCVD). However, statins can also upregulate proprotein convertase subtilisin/kexin type 9 (PCSK9), which in turn might limits the cholesterol-lowering effect of statins through the degradation of LDL receptors (LDLR). Di’ao Xinxuekang (DXXK) capsule, as a well-known traditional Chinese herbal medicine for the prevention and treatment of coronary heart disease, can alleviate lipid disorders and ameliorate atherosclerosis in atherosclerosis model mice and downregulate the expression of PCSK9. In this study, we further explored whether DXXK has a synergistic effect with atorvastatin (ATO) and its underlying molecular mechanism. The results showed that both ATO monotherapy (1.3 mg/kg) and ATO combined with DXXK therapy significantly lowered serum lipid levels and reduced the formation of atherosclerotic plaques and the liver lipid accumulation. Moreover, compared with ATO monotherapy, the addition of DXXK (160 mg/kg) to the combination therapy further lowered LDL-C by 15.55% and further reduced the atherosclerotic plaque area by 25.98%. In addition, the expression of SREBP2, PCSK9 and IDOL showed a significant increase in the model group, and the expression of LDLR was significantly reduced; however, there were no significant differences between the ATO (1.3 mg/kg) and the model groups. When ATO was combined with DXXK, the expression of LDLR was significantly increased and was higher than that of the model group and the expression of SREBP2 and PCSK9 in the liver was also significantly inhibited. Moreover, it can be seen that the expression of SREBP2 and PCSK9 in the combination treatment group was significantly lower than that in the ATO monotherapy group (1.3 mg/kg). Besides, the expression of IDOL mRNA in each treatment group was not significantly different from that of the model group. Our study suggests that DXXK might have a synergistic effect on the LDL-C lowering and antiatherosclerosis effects of ATO through the SREBP2/PCSK9 pathway. This indicates that a combination of DXXK and ATO may be a new treatment for atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

Di’ao Xinxuekang Capsule Improves the Anti-Atherosclerotic Effect of Atorvastatin by Downregulating the SREBP2/PCSK9 Signalling Pathway

Liang

Liu

et al. 2022

Front. Pharmacol.

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“…Specifically, diosgenin exhibited neuroprotective role in a hyperglycemia-induced cerebral ischemia zebrafish model by reducing oxidative damage and inflammation (Oyelaja-Akinsipo et al, 2020). In addition, previous study showed that dioscin and diosgenin treatments alleviated cerebral ischemia reperfusion injury in rats and reduced the levels of multiple proinflammatory cytokines (Li et al, 2021a). Based on these results, we could confirm that TSTT promoted repair of axonal injury and motor functional recovery following ischemic stroke, may be due to these two kinds of steroidal saponins.…”

Section: Discussionmentioning

confidence: 62%

Effect of Neurorepair for Motor Functional Recovery Enhanced by Total Saponins From Trillium tschonoskii Maxim. Treatment in a Rat Model of Focal Ischemia

Yang

Lei

et al. 2021

Front. Pharmacol.

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Trillium tschonoskii Maxim. (TTM), is a perennial herb from Liliaceae, that has been widely used as a traditional Chinese medicine treating cephalgia and traumatic hemorrhage. The present work was designed to investigate whether the total saponins from Trillium tschonoskii Maxim. (TSTT) would promote brain remodeling and improve gait impairment in the chronic phase of ischemic stroke. A focal ischemic model of male Sprague-Dawley (SD) rats was established by permanent middle cerebral artery occlusion (MCAO). Six hours later, rats were intragastrically treated with TSTT (120, 60, and 30 mg/kg) and once daily up to day 30. The gait changes were assessed by the CatWalk-automated gait analysis system. The brain tissues injuries, cerebral perfusion and changes of axonal microstructures were detected by multimodal magnetic resonance imaging (MRI), followed by histological examinations. The axonal regeneration related signaling pathways including phosphatidylinositol 3-kinases (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3 (GSK-3)/collapsin response mediator protein-2 (CRMP-2) were measured by western blotting. TSTT treatment significantly improved gait impairment of rats. MRI analysis revealed that TSTT alleviated tissues injuries, significantly improved cerebral blood flow (CBF), enhanced microstructural integrity of axon and myelin sheath in the ipsilesional sensorimotor cortex and internal capsule. In parallel to MRI findings, TSTT preserved myelinated axons and promoted oligodendrogenesis. Specifically, TSTT interventions markedly up-regulated expression of phosphorylated GSK-3, accompanied by increased expression of phosphorylated PI3K, AKT, but reduced phosphorylated CRMP-2 expression. Taken together, our results suggested that TSTT facilitated brain remodeling. This correlated with improving CBF, encouraging reorganization of axonal microstructure, promoting oligodendrogenesis and activating PI3K/AKT/GSK-3/CRMP-2 signaling, thereby improving poststroke gait impairments.

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“…Dioscin‐containing “Di‐Ao‐Xin‐Xue‐Kang” capsules have been employed to treat cardiovascular disease for as long as 20 years in China; the rhizomes of D. zingiberensis C. H. Wright are used as the medicinal component in these tablets, 3 whereas the dioscin‐containing DA‐9801 completed phase II clinical trials for treating diabetic neuropathy in the United States in 2015 106 . Dioscin (along with its glycone derivative, diosgenin) derived from D. nipponica and D. panthaica Prain et Burk were used as the active ingredients of traditional herbal medicinal products for coronary heart disease (CHD) in the former Soviet Union and China since the 1960s 107 . In 2002, Cai et al 108 demonstrated the proapoptotic, antitumor cellular mechanisms of dioscin that was purified from the root of Polygonatum zanlanscianense Pamp., which induced cell death of tumor cells with a half‐maximal inhibitory concentration (IC 50 ) of 4.4 μM.…”

Section: Sources Of Dioscin and Traditional Medicinal Valuementioning

confidence: 99%

“…106 Dioscin (along with its glycone derivative, diosgenin) derived from D. nipponica and D. panthaica Prain et Burk were used as the active ingredients of traditional herbal medicinal products for coronary heart disease (CHD) in the former Soviet Union and China since the 1960s. 107 In 2002, Cai et al 108 demonstrated the proapoptotic, antitumor cellular mechanisms of dioscin that was purified from the root of Polygonatum zanlanscianense Pamp., which induced cell death of tumor cells with a half-maximal inhibitory concentration (IC 50 ) of 4.4 μM. Extracts from D. nipponica Makino have also been in popular use for years in China and other countries for the treatment of chronic bronchitis, rheumatoid arthritis, cough, and asthma.…”

Section: Sources Of Dioscin and Traditional Medicinal Valuementioning

confidence: 99%

Dioscin: A review on pharmacological properties and therapeutic values

et al. 2021

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Dioscin has gained immense popularity as a natural, bioactive steroid saponin, which offers numerous medical benefits. The growing global incidence of disease-associated morbidity and mortality continues to compromise human health, facilitating an increasingly urgent need for nontoxic, noninvasive, and efficient treatment alternatives. Natural compounds can contribute vastly to this field. Over recent years, studies have demonstrated the remarkable protective actions of dioscin against a variety of human malignancies, metabolic

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Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases

Cited by 45 publications

References 111 publications

Di’ao Xinxuekang Capsule Improves the Anti-Atherosclerotic Effect of Atorvastatin by Downregulating the SREBP2/PCSK9 Signalling Pathway

Di’ao Xinxuekang Capsule Improves the Anti-Atherosclerotic Effect of Atorvastatin by Downregulating the SREBP2/PCSK9 Signalling Pathway

Effect of Neurorepair for Motor Functional Recovery Enhanced by Total Saponins From Trillium tschonoskii Maxim. Treatment in a Rat Model of Focal Ischemia

Dioscin: A review on pharmacological properties and therapeutic values

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