Dioscin attenuates Bleomycin-Induced acute lung injury via inhibiting the inflammatory response in mice

Wu, Zhaoli; Wang, Jia

doi:10.1080/01902148.2019.1652370

Cited by 18 publications

(13 citation statements)

References 41 publications

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“…These effects were associated with up-regulating the HSP70 and inhibiting the TLR4/MyD88/NF-κB and MAPK signaling pathways [ 394 , 395 ]. Due to its anti-inflammatory and anti-oxidative activities, dioscin also prevented bleomycin-induced pulmonary damage [ 396 ].…”

Section: Natural Compounds That Exert Anti-ali Effectsmentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

248

121

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Section: Natural Compounds That Exert Anti-ali Effectsmentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

248

121

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“…Dioscin protected against disease morbidity by decreasing the number of released proinflammatory cells and by defending the lung tissue from lung oedema, myeloperoxidase activity, and malondialdehyde content. Dioscin relieved both ALI‐induced pulmonary inflammation as well as oxidative stress in the lungs 102 …”

Section: Defense Against Organ Damagementioning

confidence: 99%

“…Dioscin relieved both ALIinduced pulmonary inflammation as well as oxidative stress in the lungs. 102 A lethal cardiopulmonary disease that has severe health consequences is pulmonary arterial hypertension (PAH). PAH is characterized by the uncontrolled proliferation of apoptosis-resistant pulmonary artery smooth muscle cells (PASMCs), which leads to pulmonary vascular remodeling (thickening of the arterial walls with the formation of lesions).…”

Section: Pulmonary-protective Effects Of Dioscinmentioning

confidence: 99%

Dioscin: A review on pharmacological properties and therapeutic values

et al. 2021

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Dioscin has gained immense popularity as a natural, bioactive steroid saponin, which offers numerous medical benefits. The growing global incidence of disease-associated morbidity and mortality continues to compromise human health, facilitating an increasingly urgent need for nontoxic, noninvasive, and efficient treatment alternatives. Natural compounds can contribute vastly to this field. Over recent years, studies have demonstrated the remarkable protective actions of dioscin against a variety of human malignancies, metabolic

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“…In addition, inflammation was inhibited by DC by reduced NF-κB, TNF-α, IL-1β, and IL-6 expressions. In addition to TLR4, these inflammatory mediators were also inhibited by DC during the amelioration of acute lung injury [219,220]. An ample body of other evidence was found supporting DC's capacity to improve liver fibrosis and acute liver injury and damage by suppressing oxidative insult and inflammation [221][222][223][224][225][226].…”

Section: Dioscin (Dc)mentioning

confidence: 99%

Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update

et al. 2021

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ROS, RNS, and carcinogenic metabolites generate excessive oxidative stress, which changes the basal cellular status and leads to epigenetic modification, genomic instability, and initiation of cancer. Epigenetic modification may inhibit tumor-suppressor genes and activate oncogenes, enabling cells to have cancer promoting properties. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that in humans is encoded by the NFE2L2 gene, and is activated in response to cellular stress. It can regulate redox homoeostasis by expressing several cytoprotective enzymes, including NADPH quinine oxidoreductase, heme oxygenase-1, UDP-glucuronosyltransferase, glutathione peroxidase, glutathione-S-transferase, etc. There is accumulating evidence supporting the idea that dietary nutraceuticals derived from commonly used fruits, vegetables, and spices have the ability to produce cancer chemopreventive activity by inducing Nrf2-mediated detoxifying enzymes. In this review, we discuss the importance of these nutraceuticals in cancer chemoprevention and summarize the role of dietary terpenoids in this respect. This approach was taken to accumulate the mechanistic function of these terpenoids to develop a comprehensive understanding of their direct and indirect roles in modulating the Keap1-Nrf2-ARE signaling system.

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Dioscin attenuates Bleomycin-Induced acute lung injury via inhibiting the inflammatory response in mice

Cited by 18 publications

References 41 publications

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Dioscin: A review on pharmacological properties and therapeutic values

Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update

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