Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats

Silambarasan, Thangarasu; Raja, Boobalan

doi:10.1016/j.ejphar.2011.12.040

Cited by 87 publications

(60 citation statements)

References 41 publications

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“…the modification of the gene expression or the modulation of different proteins. Since recent studies highlighted that flavonoids have diverse and very complex biochemical effects on living cells and organisms [1][2][3][4][17][18][19][20][21][22] further extensive investigations are reasonable to conduct in order to decipher the exact mechanism of action of DIOS.…”

Section: Effects Of Diosmetin On Mitochondrial Oxygen Consumption (Ismentioning

confidence: 99%

“…Furthermore, it is widely known that the glycoside of diosmetin called diosmin is the active ingredient of various vasoprotective medications, for example Detralex Ó or Daflon Ó (containing 450 mg diosmin) [15,16], which are capillary stabilizing agents. In addition, there have been described several other positive effects attributed to diosmin in recently published studies both in vitro and in vivo, indicating a complex mechanism of action [17][18][19][20][21][22]. Previous pharmacokinetic investigations showed that only the aglycone DIOS can enter the bloodstream (no diosmin was detected in patent's blood plasma) [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A

Poór

Veres

Jakus

et al. 2014

Journal of Photochemistry and Photobiology B: Biology

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a b s t r a c tDiosmetin (DIOS) is a flavone aglycone commonly occurring in citrus species and olive leaves, in addition it is one of the active ingredients of some medications. Based on both in vitro and in vivo studies several beneficial effects are attributed to DIOS but the biochemical background of its action seems to be complex and it has not been completely explored yet. Previous investigations suggest that most of the flavonoid aglycones have negative effect on ATP synthesis in a dose dependent manner. In our study 17 flavonoids were tested and interestingly DIOS caused a significant elevation of intracellular ATP levels after 6-and 12-h incubation in MDCK kidney cells. In order to understand the mechanism of action, intracellular ATP and protein levels, ATP/ADP ratio, cell viability and ROS levels were determined after DIOS treatment. In addition, impacts of different enzyme inhibitors and effect of DIOS on isolated rat liver mitochondria were also tested. Finally, the influence of DIOS on the ATP depleting effect of the mycotoxin, ochratoxin A was also investigated. Our major conclusions are the followings: DIOS increases intracellular ATP levels both in kidney and in liver cells. Inhibition of glycolysis or citric acid cycle does not decrease the observed effect. DIOS-induced elevation of ATP levels is completely abolished by the inhibition of ATP synthase. DIOS is able to completely reverse the ATP-depleting effect of the mycotoxin, ochratoxin A. Most probably the DIOS-induced impact on ATP system does not originate from the antioxidant property of DIOS. Based on our findings DIOS may be promising agent to positively influence ATP depletion caused by some metabolic poisons.

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Section: Effects Of Diosmetin On Mitochondrial Oxygen Consumption (Ismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A

Poór

Veres

Jakus

et al. 2014

Journal of Photochemistry and Photobiology B: Biology

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“…Silambarasan (54) . O pré-tratamento com hesperidina demonstrou efeito protetor antioxidante com a redução na geração de EROs em animais neonatos submetidos à hipóxia e isquemia do sistema nervoso central (55) .…”

Section: Discussionunclassified

“…Estes compostos fenólicos também atuam como sequestradores de EROs e quelantes da molécula de ferro livre que confirma a sua ação antioxidante (21) .…”

Section: Lista De Abreviaturasunclassified

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Efeito protetor da diosmina e hesperidina na nefrotoxidade induzida pela anfotericina B

Schlottfeldt¹

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Protective effect of Diosmin against benzo(a)pyrene‐induced lung injury in Swiss Albino Mice

Islam

Shree

Afzal

et al. 2020

Environmental Toxicology

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Diosmin, a naturally occurring flavonoid commonly present in citrus fruit, is known to exhibit anti-inflammatory, antimutagenic, antioxidant, and free radical scavenging as well as blood lipid lowering activities among others. Diosmin has also been used for the treatment of various diseases including diabetes mellitus and Alzheimer's disease. Our study explores the role of Diosmin in pulmonary toxicity (lung injury) induced by environmental contaminant benzo(a)pyrene [B(a)P]. Swiss Albino Mice (SAM) were administered with either Diosmin 100 or 200 mg/kg body weight daily for 14 days and then challenged with a single dose of B(a)P. On the 15th day, animals were sacrificed; lung tissues and blood were collected for molecular analysis. B(a)P administration in mice induced the thickening of lung epithelium, damaged alveolar architecture, and promoted inflammatory cell infiltration in the lung tissues. Also, B[a]P significantly increased the expression of NF-kB, COX-2, IL-6, Bax, cleaved caspase 3, and cleaved PARP proteins and decreased antioxidant enzyme levels. Diosmin-100 and Diosmin-200 significantly attenuated the damage to lung epithelium, alveolar architecture, and reduced inflammatory cell infiltration in the lung tissues of mice. Diosmin significantly (P < .05) attenuated the levels of oxidative stress markers: lactate dehydrogenase and xanthine oxidase. A decrease in expression of NF-kB, COX-2, IL-6, Bax, cleaved caspase 3, and cleaved PARP proteins in mice was challenged with B[a]P. Diosmin thus could be a promising therapeutic adjuvant against B[a]Pinduced oxidative stress and lung damage. K E Y W O R D S benzo(a)pyrene, diosmin, inflammation, lung injury, oxidative stress, pulmonary toxicity

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Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats

Cited by 87 publications

References 41 publications

Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A

Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A

Efeito protetor da diosmina e hesperidina na nefrotoxidade induzida pela anfotericina B

Protective effect of Diosmin against benzo(a)pyrene‐induced lung injury in Swiss Albino Mice

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