Diosmin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology

Gervasi, Teresa; Patanè, Giuseppe Tancredi; Calderaro, Antonella; Mandalari, Giuseppina; Barreca, Davide

doi:10.1007/978-3-030-94753-8_7-1

Handbook of Dietary Flavonoids 2023

DOI: 10.1007/978-3-030-94753-8_7-1

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Diosmin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology

Teresa Gervasi,

Giuseppe Tancredi Patanè,

Antonella Calderaro

et al.

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Cited by 3 publications

References 85 publications

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Diosmin: A promising phytochemical for functional foods, nutraceuticals and cancer therapy

Rahman,

Talha Khalil,

Ahsan Shahid

et al. 2024

Food Science & Nutrition

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Diosmin, a potent bioflavonoid derived from citrus fruits, has gained significant attention for its anticancer potential, reflecting a critical need in the ongoing battle against cancer. Amidst increasing cancer incidence, the quest for safer and more effective treatments has brought diosmin to the forefront, given its unique pharmacological profile distinct from other flavonoids. Diosmin's anticancer mechanisms are multifaceted, involving apoptosis induction, angiogenesis inhibition, and metastasis prevention. Extensive research encompassing cellular studies, animal models, and limited clinical trials underscores its efficacy not only against cancer but also in managing chronic venous insufficiency and hemorrhoids, attributing to its anti‐inflammatory properties. Furthermore, diosmin exhibits low toxicity and complements conventional chemotherapy, proposing its utility as an adjunct therapy in cancer treatment protocols. The review delves into the specific anticancer advantages of diosmin, distinguishing it from the broader flavonoid category. It provides a detailed analysis of its implications in preclinical and clinical settings, advocating for its consideration in the oncological therapeutic arsenal. By juxtaposing diosmin with other herbal medicines, the review offers a nuanced perspective on its role within the wider context of natural anticancer agents, emphasizing the need for further clinical research to substantiate its efficacy and safety in oncology.

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Diosmin: A promising phytochemical for functional foods, nutraceuticals and cancer therapy

Rahman,

Talha Khalil,

Ahsan Shahid

et al. 2024

Food Science & Nutrition

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Evaluation of the efficacy of diosmin and chrysin against tau-fluvalinate exposure in rats

Gedik,

Eraslan

2025

Food and Chemical Toxicology

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Inhibitory mechanism of chrysin and diosmetin to α-glucosidase: insights from kinetics, multispectroscopy and molecular docking investigations

Zhang,

Li,

Zhai

et al. 2024

Journal of Biomolecular Structure and Dynamics

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Diosmin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology

Cited by 3 publications

References 85 publications

Diosmin: A promising phytochemical for functional foods, nutraceuticals and cancer therapy

Diosmin: A promising phytochemical for functional foods, nutraceuticals and cancer therapy

Evaluation of the efficacy of diosmin and chrysin against tau-fluvalinate exposure in rats

Inhibitory mechanism of chrysin and diosmetin to α-glucosidase: insights from kinetics, multispectroscopy and molecular docking investigations

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