Diosmin Prevents Isoproterenol-Induced Heart Mitochondrial Oxidative Stress in Rats

queenthy, S Sharmila; Prince, P. Stanely Mainzen; John, Babu

doi:10.1007/s12012-017-9422-2

Cited by 28 publications

(10 citation statements)

References 30 publications

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“…No significant difference/observance between the control group and diosmin‐alone group in term of oxidative stress parameter (MDA, NO, SOD, CAT, GSH‐Px, and GSH), biochemical parameters (AST, ALT, ALP, and LDH), histological architecture, body weight, liver weight, and liver weight/body weight ratio ascertained that diosmin did not cause negative effect at the specified dose and duration examined. Findings from diosmin administered at different doses and times, the parameters of oxidative stress (Arab et al, ; Eraslan et al, ; Rehman et al, ; Sharmila Queenthy, Stanely Mainzen Prince, & John, ), biochemical parameters (Eraslan et al, ; Sharmila Queenthy et al, ), liver histology (Eraslan et al, ; Rehman et al, ) findings obtained from this study are consistent with the findings obtained.…”

Section: Discussionsupporting

confidence: 89%

“…In addition, diosmin/diosmetin also has a protective effect against peroxidation by inhibiting the oxidation of cell membrane phospholipids (Villa et al, ). When the previously performed studies involving different compounds with diosmin were evaluated, the oxidative stress parameters (Arab et al, ; Eraslan et al, ; Jain et al, ; Sharmila Queenthy et al, ; Srinivasan & Pari, ; Tahir et al, ; Wojnar, Kaczmarczyk‐Sedlak, & Zych, ), some biochemical parameters (Eraslan et al, ; Sharmila Queenthy et al, ; Tahir et al, ), and liver histopathology (Eraslan et al, ; Rehman et al, ; Srinivasan & Pari, ; Tahir et al, ) similar to those found.…”

Section: Discussionmentioning

confidence: 99%

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The effect of diosmin against liver damage caused by cadmium in rats

Ağır

Eraslan

2019

J Food Biochem

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A total of 40, male Wistar Albino, 2–3‐months‐old rats were used and divided into four groups. Control group received the vehicle alone, diosmin group received 100 mg/kg.bw diosmin, the cadmium group received 200 ppm cadmium, cadmium plus diosmin group received 200 ppm cadmium, and 100 mg/kg.bw diosmin for 30 days. Some biochemical parameters (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase) and oxidative stress parameters (malondialdehyde [MDA], nitric oxide [NO], superoxide dismutase [SOD], catalase [CAT], gluthatione peroxidase [GSH‐Px], and glutathione [GSH]) were analyzed in the samples. Histo‐pathological findings were evaluated in the liver. The body weights and liver weights of the animals were measured. The MDA and NO levels and biochemical enzyme activities examined were increased, whereas SOD, CAT, and GSH‐Px activities and GSH levels decreased in cadmium‐exposed group. There were also negative changes in body weight, liver weight, and liver tissue histo‐phathology. Positive improvements were observed in all these parameters evaluated of the group co‐administered cadmium and diosmin. Practical applications Cadmium is one of the common environmental pollutants. Diosmin is a type of flavonoid found mainly in citrus fruits. It can also be produced from hesperidine. This compound is used for medical purposes and also has strong antioxidant properties. One of the toxic effects mechanisms of cadmium is oxidative stress and causes liver damage with different pathways. This compound can be used as a supporting agent in addition to the main treatment options against liver damage in case of exposure to possible cadmium. This flavonoid can also be taken with food for prophylactic purposes.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

The effect of diosmin against liver damage caused by cadmium in rats

Ağır

Eraslan

2019

J Food Biochem

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“…Malonaldehyde (MD) is a major end product formed by lipid peroxidation of polyunsaturated fatty acids during oxidation in cardiomyocyte. Increase in the MD content is an indication of oxidative stress, which progresses to irreversible damage to myocardial muscles, and is seen in ISO-induced myocardial ischemia [45]. Investigations made here indicate animals administered with ISO and left untreated (group II) had significantly elevated levels of MD compared to the control group (group I).…”

Section: Anti-inflammatory Effect Of Rpgmentioning

confidence: 55%

Cardioprotective Effect of Rhapontigenin in Isoproterenol-Induced Myocardial Infarction in a Rat Model

Fan

2019

Pharmacology

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Background/Aims: Rhapontigenin (RPG) is a stilben derivative and is known to bear several effects such as antiallergic, anticoagulative, hypoglycemic, antiangiogenic, and purgative. The investigation was conducted to evaluate the cardioprotective efficacy of RPG in rats having acute myocardial infarction (MI) induced by isoproterenol (ISO). Methods: Animals were divided into 6 groups: group I (control group), group II (ISO-treated), group III (1.0 mg/kg/day RPG and ISO-treated), group IV (2.5 mg/kg/day RPG and ISO-treated), group V (5.0 mg/kg/day RPG and ISO-treated), and group VI (treated with RPG 5.0 mg/kg/day). Various cardiac stress markers, including infarct size and heart/body weight index, were investigated in animals with ISO-induced MI, such as inducible nitric oxide synthase (iNOS), creatinine kinase (CK), lactate dehydrogenase (LD), cardiac troponin-T (CTT), superoxide dismutase (SOD), and malondialdehyde. INOS, p38, caspase-3, and connexin 43 expressions were analyzed in animals. Inflammatory mediators, tissue necrosis factor-α (TNF-α) and interleukin-6 (IL-6), were detected in serum of experimental animals. Results: Group I animals indicated normal levels of biochemical parameters, whereas group II animals indicated high levels of these parameters and successful induction of MI. Pretreatment of animal groups III, IV, and V with RPG revealed amelioration of infarct size, heart/body weight index, CK, LD, CTT in rats, whereas group VI animals were treated only with RPG (5.0 mg/kg/day) and not with ISO. Levels of TNF-α, IL-6, MD, SOD, p38, and iNOS expressions were significantly downregulated by RPG administration (5.0 mg/kg/day). Conclusion: RPG ameliorates MI caused by ISO in rats and provides cardioprotective effect, via anti-inflammatory, antioxidant, and antiapoptotic effect.

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“… 30 The oxidative stress response can cause damage to mitochondria and plays an important role in cardiac pathological processes. 31 The heart is a high oxygen-consuming, high energy-consuming organ. During the course of life, the heart’s orderly diastolic contraction activity relies on cardiomyocytes to increase energy support.…”

Section: Introductionmentioning

confidence: 99%

<p>Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases</p>

Tan¹,

Chen²,

Li³

2020

DDDT

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Cardiovascular disease (CVD), the number one cause of death worldwide, has always been the focus of clinical and scientific research. Due to the high number of deaths each year, it is essential to find alternative therapies that are safe and effective with minimal side effects. Traditional Chinese medicine (TCM) has a long history of significant impact on the treatment of CVDs. The mode of action of natural active ingredients of drugs and the development of new drugs are currently hot topics in research on TCM. Astragalus membranaceus is a commonly used Chinese medicinal herb. Previous studies have shown that Astragalus membranaceus has anti-tumor properties and can regulate metabolism, enhance immunity, and strengthen the heart. Astragaloside IV (AS-IV) is the active ingredient of Astragalus membranaceus , which has a prominent role in cardiovascular diseases. AS-IV can protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial hypertrophy and myocardial fibrosis, enhance myocardial contractility, improve diastolic dysfunction, alleviate vascular endothelial dysfunction, and promote angiogenesis. It can also regulate blood glucose and blood lipid levels and reduce the risk of cardiovascular diseases. In this paper, the mechanism of AS-IV intervention in cardiovascular diseases in recent years is reviewed in order to provide a reference for future research and new drug development.

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Diosmin Prevents Isoproterenol-Induced Heart Mitochondrial Oxidative Stress in Rats

Cited by 28 publications

References 30 publications

The effect of diosmin against liver damage caused by cadmium in rats

The effect of diosmin against liver damage caused by cadmium in rats

Cardioprotective Effect of Rhapontigenin in Isoproterenol-Induced Myocardial Infarction in a Rat Model

<p>Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases</p>

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