Diospolysaponin A, a New Polyoxygenated Spirostanol Saponin from the Tubers of Dioscorea polygonoides.

Abstract

SteroidsSteroids U 0300 Diospolysaponin A, a New Polyoxygenated Spirostanol Saponin from the Tubers of Dioscorea polygonoides. -(OSORIO, J. N.; MOSQUERA MARTINEZ, O. M.; CORREA NAVARRO, Y. M.; MIMAKI*, Y.; SAKAGAMI, H.; SASHIDA, Y.; Heterocycles 60 (2003) 7, 1709-1715; Sch. Pharm., Univ. Pharm. Life Sci., Hachioji, Tokyo 192, Japan; Eng.) -Mais 43-160

The Dioscorea genus: a review of bioactive steroid saponins

“…These saponins presented mainly a 25(R) position (1-18, 20, 21, 26-30), or a 25(S) (22)(23)(24)(25). About the E ring, a satured one can be found (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12), or with insaturations in the positions 20 (22) (13)(14)(15)(16)(17)(18) or 22 (23) on the open F ring (26). A seco-furostane skeleton is equally described (27)(28)(29)(30).…”

“…hypoglauca [8][9][10][11][12][13], D. deltoidea var. orbiculata [14], D. futschauensis [15][16][17][18][19][20], D. nipponica [21], D. panthaica [22][23][24], D. parviflora [25], D. polygonoides [26,27], D. pseudojaponica [28], D. spongiosa [29], D. villosa [30], and D. zingiberensis [31] (Table 1). The structures of the aglycons of the isolated saponins belonged to three skeleton types: furostane, a pentacyclic ABCDE-ring system with a sixth open F ring (1-30); spirostane, a hexacyclic ABCDEF-ring system (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46); and pregnane, a tetracyclic ABCD-ring system (47-58) (Figs.…”