Diospyros malabarica fruit preparation mediates immunotherapeutic modulation and epigenetic regulation to evoke protection against non–small cell lung cancer (NSCLC)

Bhootra, Sannidhi; Jill, Nandana; Rajak, Rohit; Shanmugam, Geetha; Rakshit, Sudeshna; Kannanthodi, Samiyah; Thakkar, Vidhi; George, Melvin; Sarkar, Koustav

doi:10.1016/j.jep.2023.116525

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…Blood samples were collected from patients aged between 35 and 65 years in SRM Medical College Hospital who were diagnosed as having either early stage of breast cancer (invasive ductal carcinoma, IDC) or nonsmall-cell lung cancer (NSCLC). 17 For the control, blood samples were collected from agematched healthy donors with no prior cancer diagnosis. All these samples were collected from the antecubital vein in the forearm by clinician−investigators of the current project for documentation and study purposes.…”

Section: Collection Of Samplesmentioning

confidence: 99%

“…Past decades of patients with surgically resected stage IA, stage IB, and stage II nonsmall-cell lung cancers (NSCLCs) had an overall survival rate of 83, 69, and 48%, respectively . Accordingly, it is significant to identify novel diagnostic and therapeutic biomarkers for the recognition of early stage lung cancer and for the advance of new molecular targeted therapies for NSCLCs. , On the other hand, Wong et al investigated the effect of a polymer-based system on the cytotoxicity of breast cancer cells. They obtained the outcome of breast cancer cells of around 60% of the multidrug-resistant (MDR) process .…”

Section: Introductionmentioning

confidence: 99%

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Unprecedented Approach of Fabrication and Analysis of a Bioactive PDMS/Hydroxyapatite/Graphene Nanocomposite Scaffold with a Vascular Channel to Combat Carcinogenesis

Ayyanar,

Rakshit,

Sarkar

et al. 2024

ACS Appl. Bio Mater.

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In the present investigation, natural bone-derived hydroxyapatite (HA, 2 wt %) and/or exfoliated graphene (Gr, 0.1 wt %)-embedded polydimethylsiloxane (PDMS) elastomeric films were prepared using a vascular method. The morphology, mechanical properties, crystallinity, and chemical structure of the composite films were evaluated. The in vitro biodegradation kinetics of the films indicates their adequate physiological stability. Most of the results favored PDMS/HA/Gr as a best composite scaffold having more than 703% elongation. A simulation study of the microfluidic vascular channel of the PDMS/HA/Gr scaffold suggests that the pressure drop at the outlet became greater (from 1.19 to 0.067 Pa) unlike velocity output (from 0.071 to 0.089 m/s), suggesting a turbulence-free laminar flow. Our bioactive scaffold material, PDMS/HA/Gr, showed highest cytotoxicity toward the lung cancer and breast cancer cells through Runx3 proteinmediated cytotoxic T lymphocyte (CTL) generation. Our data and predicted mechanism also suggested that the PDMS/HA/Grsupported peripheral blood mononuclear cells (PBMCs) not only increased the generation of CTL but also upregulated the expression of RUNX3. Since the PDMS/HA/Gr scaffold-supported Runx3 induced CTL generation caused maximum cell cytotoxicity of breast cancer (MCF-7) and lung cancer (A549) cells, PDMS/HA/Gr can be treated as an excellent potential candidate for CTL-mediated cancer therapy.

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Section: Collection Of Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unprecedented Approach of Fabrication and Analysis of a Bioactive PDMS/Hydroxyapatite/Graphene Nanocomposite Scaffold with a Vascular Channel to Combat Carcinogenesis

Ayyanar,

Rakshit,

Sarkar

et al. 2024

ACS Appl. Bio Mater.

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Anticancer therapeutic potential of genus Diospyros: From phytochemistry to clinical applications—A review

Rauf,

Akram,

Hafeez

et al. 2024

Food Science & Nutrition

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The genus Diospyros has gained significant attention in the scientific community owing to its diverse bioactivities ascribed to specific bioactive constituents present in different species of this plant. Phytochemicals like flavonoids, terpenoids, and xanthones have been reported to be present in other Diospyros species responsible for their pharmacological properties. These compounds are well known for their diverse potent therapeutic potentials, such as antimicrobial, antioxidant, anti‐inflammatory, and anticancer properties. This review enlightens the details of the Genus Diospyros, ranging from an overview of its species to an in‐depth analysis of phytochemistry, ethnopharmacology, and their potential as anticancer agents. Different species, including Diospyros lotus, Diospyros kaki, Diospyros maritima, Diospyros mespiliformis, and Diospyros tricolor, presented with an enormous range of anticancer activities against human cancer cell cultures. Moreover, this review highlights the results of various in vitro (antiproliferative, cytotoxic effects against), in vivo (inhibition of tumor, apoptosis), and in silico (GLU234, GLU278, and LYS158 protein residues) studies, elucidating its preclinical anticancer potential. The anticancer potential displays inhibition of cellular proliferation, induction of apoptosis, and mitigation of angiogenesis. Furthermore, this review may elaborate the use of traditional knowledge, modern research, and potential therapeutic applications in the field of anticancer ethnopharmacology. As the modern‐day research approaches novel alternatives to combat diseases like cancer, the Genus Diospyros may emerge as a promising avenue with the potential to yield innovative and effective therapeutic agents.

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Immunomodulatory effects of Diospyros peregrina fruit preparation (DFP) in non-small cell lung cancer (NSCLC) by utilizing dendritic cell-mediated antigen presentation and T helper (TH) cell differentiation

Sriraman,

Sarkar,

Naskar

et al. 2024

Med Oncol

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Diospyros malabarica fruit preparation mediates immunotherapeutic modulation and epigenetic regulation to evoke protection against non–small cell lung cancer (NSCLC)

Cited by 5 publications

References 32 publications

Unprecedented Approach of Fabrication and Analysis of a Bioactive PDMS/Hydroxyapatite/Graphene Nanocomposite Scaffold with a Vascular Channel to Combat Carcinogenesis

Unprecedented Approach of Fabrication and Analysis of a Bioactive PDMS/Hydroxyapatite/Graphene Nanocomposite Scaffold with a Vascular Channel to Combat Carcinogenesis

Anticancer therapeutic potential of genus Diospyros: From phytochemistry to clinical applications—A review

Immunomodulatory effects of Diospyros peregrina fruit preparation (DFP) in non-small cell lung cancer (NSCLC) by utilizing dendritic cell-mediated antigen presentation and T helper (TH) cell differentiation

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