Dioxinodehydroeckol: A Potential Neuroprotective Marine Compound Identified by In Silico Screening for the Treatment and Management of Multiple Brain Disorders

Ahmad, Faizan; Sachdeva, Punya; Sachdeva, Bhuvi; Singh, Gagandeep; Soni, Hemant; Tandon, Smriti; Rafeeq, Misbahuddin M; Alam, Mohammad Zubair; Baeissa, Hanadi M.; Khalid, M. Al-Harbi

doi:10.1007/s12033-022-00629-3

Cited by 6 publications

(3 citation statements)

References 77 publications

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“…Therefore, it has been confirmed in numerous studies that depression as a neurodegenerative disorder resulting in atrophy of the brain regions 21 . Neurodegenerative disorders develop due to loss of neurons, resulting in a decline in cognitive functioning of the brain 22–28 . Several studies have identified the hippocampus as the key brain region linked to depression, and hippocampal plasticity occurs in patients with depression 29 .…”

Section: Overview On Depressionmentioning

confidence: 96%

“… 21 Neurodegenerative disorders develop due to loss of neurons, resulting in a decline in cognitive functioning of the brain. 22 , 23 , 24 , 25 , 26 , 27 , 28 Several studies have identified the hippocampus as the key brain region linked to depression, and hippocampal plasticity occurs in patients with depression. 29 Interestingly, nutritional deficiencies have been observed to initiate and exacerbate depression and anxiety.…”

Section: Overview On Depressionmentioning

confidence: 99%

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Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Sachdeva

Sachdeva²,

Ghosh

et al. 2023

Ibrain

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Major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) are the most common causes of emotional distress that impair an individual's quality of life. MDD is a chronic mental illness that affects 300 million people across the world. Clinical manifestations of MDD include fatigue, loss of interest in routine tasks, psychomotor agitation, impaired ability to focus, suicidal ideation, hypersomnolence, altered psychosocial functioning, and appetite loss. Individuals with depression also demonstrate a reduced behavioral response while experiencing pleasure, a symptom known as anhedonia. Like MDD, PTSD is a prevalent and debilitating psychiatric disorder resulting from a traumatic incident such as sexual assault, war, severe accident, or natural disaster. Symptoms such as recalling event phases, hypervigilance, irritability, and anhedonia are common in PTSD. Both MDD and PTSD pose enormous socioeconomic burdens across the globe. The search for effective treatment with minimal side effects is still ongoing. Ketamine is known for its anesthetic and analgesic properties. Psychedelic and psychotropic effects of ketamine have been found on the nervous system, which highlights its toxicity. In this article, the effectiveness of ketamine as a potential therapeutic for PTSD and MDD along with its mechanisms of action, clinical trials, and possible side effects have been discussed.

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Section: Overview On Depressionmentioning

confidence: 96%

Section: Overview On Depressionmentioning

confidence: 99%

Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Sachdeva

Sachdeva²,

Ghosh

et al. 2023

Ibrain

Self Cite

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show abstract

“…Brain tissues from Alzheimer's patients also contained fungal chitin [15]. AD is one of the most recurrent neurodegenerative disorders that affect a person's language acquisition, perception, memory, and thoughts [16][17][18][19][20][21][22][23][24][25], which leads to overall impaired cognition [26,27]. Additionally, those with multiple sclerosis had chitin deposition.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges

Sachdeva

Sachdeva²,

Negi

et al. 2023

Marine Drugs

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Chitin is the second most abundant biopolymer consisting of N-acetylglucosamine units and is primarily derived from the shells of marine crustaceans and the cell walls of organisms (such as bacteria, fungi, and algae). Being a biopolymer, its materialistic properties, such as biodegradability, and biocompatibility, make it a suitable choice for biomedical applications. Similarly, its deacetylated derivative, chitosan, exhibits similar biocompatibility and biodegradability properties, making it a suitable support material for biomedical applications. Furthermore, it has intrinsic material properties such as antioxidant, antibacterial, and antitumor. Population studies have projected nearly 12 million cancer patients across the globe, where most will be suffering from solid tumors. One of the shortcomings of potent anticancer drugs is finding a suitable cellular delivery material or system. Therefore, identifying new drug carriers to achieve effective anticancer therapy is becoming essential. This paper focuses on the strategies implemented using chitin and chitosan biopolymers in drug delivery for cancer treatment.

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Unraveling the crystal structure, stability and drug likeness of 1,3,4-oxadiazole derivatives against Myelofibrosis: a combined experimental and computational investigation

Tumakuru Nagarajappa,

Chikkappaiahnayaka,

Benedict Leoma

et al. 2024

Journal of Biomolecular Structure and Dynamics

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Dioxinodehydroeckol: A Potential Neuroprotective Marine Compound Identified by In Silico Screening for the Treatment and Management of Multiple Brain Disorders

Cited by 6 publications

References 77 publications

Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges

Unraveling the crystal structure, stability and drug likeness of 1,3,4-oxadiazole derivatives against Myelofibrosis: a combined experimental and computational investigation

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