Dioxins, polychlorinated biphenyls and other organohalogen compounds in human milk. Levels, correlations, trends and exposure through breastfeeding

Fürst, Peter

doi:10.1002/mnfr.200600008

Cited by 129 publications

(66 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the PBDE burden of these patients was much lower than among occupational workers (with a mean PBDEs of 600 ng/g lipid) from Guiyu, as reported by Bi et al (2007). Nevertheless, the level of PBDE burden in the patient population was higher than those in the general European and Asian populations, which were generally below 5 ng/g lipid (Furst, 2006;Inoue et al, 2006;Lorber, 2008;Schecter et al, 1996Schecter et al, , 2003). Generally, North Americans tend to have higher body burdens of PBDEs than Europeans and Asians (Hites, 2004;Sjödin et al, 2003;Wang et al, 2007).…”

Section: Pbde Concentration In Human Semen Compared With In Human Bloodmentioning

confidence: 54%

Determination of polybrominated diphenyl ethers in human semen

Liu

Zhao

Zhu

et al. 2012

Environment International

View full text Add to dashboard Cite

Some persistent organic pollutants (POPs) have been found in human semen but until this point it was unclear whether polybrominated diphenyl ethers (PBDEs) could be detected in human semen. In this study, PBDEs were found for the first time in human semen samples (n = 101) from Taizhou, China. The concentrations of total PBDEs (∑PBDEs) varied from 15.8 to 86.8 pg/g ww (median = 31.3 pg/g ww) and 53.2 to 121 pg/g ww (median = 72.3 pg/g ww) in semen and blood samples, respectively. The ∑PBDE level in semen was about two times lower than in human blood, which was different in the distribution in the two matrices from other POPs. A correlation of ∑PBDE concentration was found between paired semen and in blood. The results suggest that semen could be used to detect PBDE burden in human body as a non-invasive matrix. In addition, the levels of BDE-209 and BDE-153, especially the latter, were much higher in blood than in semen, while the levels of BDE-28, BDE-47 and BDE-99 were comparable in the two matrices, suggesting that low brominated congeners could be more easily transferred to semen than high brominated congeners. Considering different toxicities among the PBDE congeners, it might be more significant to measure PBDEs in semen than in blood for evaluating male reproduction risks of PBDEs.

show abstract

Section: Pbde Concentration In Human Semen Compared With In Human Bloodmentioning

confidence: 54%

Determination of polybrominated diphenyl ethers in human semen

Liu

Zhao

Zhu

et al. 2012

Environment International

View full text Add to dashboard Cite

show abstract

“…Figure 6 shows the median levels of total DDT in more than 7000 Figure 6. Temporal trend of total DDT levels in human milk samples (> 7000 individual samples from Germany) (BgVV, 2000;NLGA, 2004;Fürst, 2006).…”

Section: Time Trendmentioning

confidence: 99%

Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to DDT as an undesirable substance in animal feed

2006

EFS2

View full text Add to dashboard Cite

European countries for most uses in the early 1970s. The use of DDT as a pesticide has been very restrictive since 1981 and banned since 1986 in the EU. Although being banned in most countries worldwide, DDT is still used for vector control especially in areas with endemic malaria, and extended use was recently recommended by WHO for indoor residual spraying to control malaria.Because of the lipophilic properties and persistence in the environment, DDΤ and related compounds are bioaccumulated and biomagnified along the food chain. DDT is included in the Stockholm convention on persistent organic pollutants (POPs) 1 and the United Nations Economic Commission for Europe (UNECE) Convention on long-range transboundary air pollution protocol on POPs (CLRTAP-POP).DDT is readily absorbed in humans and animals; the half-life for DDT varies from one month in rats to four years in humans. In animals and humans DDE is generally more persistent than DDT. DDT and related compounds are transferred to milk and egg and accumulate in domestic animals and fish. DDT has low acute toxicity to mammals and most bird species.The main target organs are the nervous system and the liver. It also affects hormonal tissues, reproduction, fetal development and the immune system. DDT including p,p'-DDE and DDD cause tumours mainly in the liver of experimental animals and are mostly negative in In its evaluation of DDT, the CONTAM Panel examined occurrence data to assess the levels that are currently found in the environment and in food and feed. Feed materials of animal origin, especially fish derived products, are in general more contaminated than feed materials of plant origin. In feed samples of animal origin the metabolite p,p'-DDE normally represents more than 50 % of sum of DDT. A considerable lower contribution of p,p'-DDE to the sum of DDT may indicate recent use of DDT. Samples of plant origin are generally dominated by the parent compound p,p'-DDT. Feed commodities including fish derived products generally contain levels in the low μg/kg range and thus are far below those that have been found to cause adverse effects in fish and domestic animals. However, it can not be excluded that elevated levels may be found in feed commodities that originate from areas where DDT has recently been or still is used.Despite its presence in the environment, many foodstuffs and animal feed, the data show a considerable decline of up to 90 % in human exposure to DDT and related compounds over the past three decades. Food of animal origin is the major source of human exposure and recent studies performed in some EU Member States indicate a mean dietary intake for adults and children of 5 -30 ng/kg b.w. per day. This exposure level is more than two orders of magnitude below the PTDI of 0.01 mg/kg b.w.

show abstract

“…1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 Year µg/kg milk fat Figure 4. Median HCB levels in 1902 individual human milk samples from North RhineWestphalia/Germany in the course of time (Fürst, 2006).…”

Section: Background Human Exposure Levelsmentioning

confidence: 99%

Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to Hexachlorobenzene as undesirable substance in animal feed

2006

EFSA Journal

View full text Add to dashboard Cite

Dioxins, polychlorinated biphenyls and other organohalogen compounds in human milk. Levels, correlations, trends and exposure through breastfeeding

Cited by 129 publications

References 20 publications

Determination of polybrominated diphenyl ethers in human semen

Determination of polybrominated diphenyl ethers in human semen

Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to DDT as an undesirable substance in animal feed

Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to Hexachlorobenzene as undesirable substance in animal feed

Contact Info

Product

Resources

About