Dip Coating: A New Dip Coating Method Using Supporting Liquid for Forming Uniformly Thick Layers on Serpentine 3D Substrates (Adv. Mater. Interfaces 24/2019)

Lim, Jongkyeong; Kim, A‐Reum; Kim, Seonghyun; Lee, Sang‐Min; Yoo, Dong‐Woo; Park, Jaechan; Kim, Joonwon

doi:10.1002/admi.201970149

Cited by 9 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fabrication process consists of five steps, as shown in Figure a: 1) 3D vascular substrates were printed using computer‐aided design (CAD) data, where vascular medical imaging data obtained through computed tomography (CT) angiography or magnetic resonance imaging (MRI) scans were modified to arbitrary shapes. 2) Following a previously reported protocol, [ 29 ] we uniformly coated a thick elastomer (e.g., polydimethylsiloxane [PDMS]) layer on the surface of the 3D vascular substrates using the dip coating method based on a supporting liquid; 2‐1) The 3D vascular substrates were immersed and oscillated in a biphasic liquid bath where a PDMS prepolymer solution floated on an immiscible, density‐matched, interfacial‐tension‐minimized supporting liquid. 2‐2) The PDMS prepolymer coating deposited on the 3D vascular substrates was then cured within the supporting liquid.…”

Section: Resultsmentioning

confidence: 99%

“…Based on a previously reported protocol, [ 29 ] 3D vascular replicas composed of an elastomeric monolayer were fabricated by coating a thick elastomeric layer on the surface of the 3D vascular substrates using the dip coating method based on a supporting liquid and then completely dissolving the 3D vascular substrates. First, the supporting liquid was prepared by mixing 14% v/v glycerol (Samchun G0274) and 40 μ m Tween 80 (Sigma‐Aldrich 59924) in DI water and then raising the temperature to 70 °C on a hot plate.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

3D Vascular Replicas Composed of Elastomer–Hydrogel Skin Multilayers for Simulation of Endovascular Intervention

Lim

Kim

2020

Adv Funct Materials

Self Cite

View full text Add to dashboard Cite

Multilayered 3D vascular replicas incorporating the complementary advantages of elastomers and hydrogels can serve as a training platform to realistically simulate endovascular intervention, the preferred therapeutic procedure for cardio‐cerebrovascular disease. However, the fabrication process is challenging because of the difficulty in uniformly coating a thin hydrogel layer only on the inner surface of tortuous 3D vascular replicas composed of an elastomer monolayer. This study proposes an effective strategy to design and produce high‐fidelity 3D vascular replicas composed of elastomer–hydrogel multilayers by coating hydrogel polymers with robust interfaces only on the inner surface of the elastomer monolayer. The thin hydrogel layer can impart soft surface elasticity, lubricity, and superaerophobicity to the elastomer monolayer with high bulk elasticity, with deionized water alone as the circulating liquid, without the aid of additional lubricants. Owing to the complementary properties of the elastomers and hydrogels, multilayered 3D vascular replicas facilitate the control of medical devices and internal circulation of fluids, enabling realistic simulations of endovascular intervention under optical images in addition to X‐ray angiography. Furthermore, through practice courses, neurosurgeons demonstrated that the multilayered 3D vascular replicas are a reasonable platform for developing hand–eye coordination with pre‐procedure simulations and case‐specific training on demanding surgical sites.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

3D Vascular Replicas Composed of Elastomer–Hydrogel Skin Multilayers for Simulation of Endovascular Intervention

Lim

Kim

2020

Adv Funct Materials

Self Cite

View full text Add to dashboard Cite

show abstract

“…The 3D vascular replica, which comprises multiple layers of elastomer‐hydrogel skin, can mimic the shape and properties of blood vessels. [ 25 ] Blood‐mimicking fluid was circulated in the 3D vascular replica at a flow rate and frequency of 210 mL min −1 and 70 Hz, respectively, using a pulsatile blood pump; the fluid then traversed from a filtration system (opening size of sieve: 20 µm) to a fluid reservoir ( Figure a). The filtration system can check whether microscopic fragments are generated during the simulation procedure.…”

Section: Figurementioning

confidence: 99%

“…The clinical applicability of OFI‐MD was confirmed using the endovascular simulator. [ 25 ] The simulator comprised a mannequin integrated with 3D vascular replicas (cerebral, carotid, iliac, femoral arteries, and aorta), digital microscope, fluid reservoir, and pulsatile blood pump ( Figure a). The blood‐mimicking fluid was circulated in the replicas at a flow rate of 280 mL min −1 at 70 Hz using the pulsatile blood pump.…”

Section: Figurementioning

confidence: 99%

Embolization of Vascular Malformations via In Situ Photocrosslinking of Mechanically Reinforced Alginate Microfibers using an Optical‐Fiber‐Integrated Microfluidic Device

et al. 2021

Self Cite

View full text Add to dashboard Cite

Embolization, which is a minimally invasive endovascular treatment, is a safe and effective procedure for treating vascular malformations (e.g., aneurysms). Hydrogel microfibers obtained via spatiotemporally controllable in situ photocrosslinking exhibit great potential for embolizing aneurysms. However, this process is challenging because of the absence of biocompatible and morphologically stable hydrogels and the difficulty in continuously spinning the microfibers via in situ photocrosslinking in extreme endovascular environments such as those involving a tortuous geometry and high absorbance. A double‐crosslinked alginate‐based hydrogel with tantalum nanopowder (DAT) that exploits the synergistic effect of covalent crosslinking by visible‐light irradiation and ionic crosslinking using Ca2+, which is present in the blood, is developed in this study. Furthermore, an effective strategy to design and produce an optical‐fiber‐integrated microfluidic device (OFI‐MD) that can continuously spin hydrogel microfibers via in situ photocrosslinking in extreme endovascular environments is proposed. As an embolic material, DAT exhibits promising characteristics such as radiopacity, nondissociation, nonswelling, and constant mechanical strength in blood, in addition to excellent cyto‐ and hemo‐compatibilities. Using OFI‐MD to spin DAT microfibers continuously can help fill aneurysms safely, uniformly, and completely within the endovascular simulator without generating microscopic fragments, which demonstrates its potential as an effective embolization strategy.

show abstract

“…In addition, to increase their utilization as a simulator in emergency situations, their manufacturing time should be short. Previous studies by our group [ 1,6 ] described the development of 3D vascular replicas composed of elastomer‐hydrogel skin multilayers that mimic the geometry and properties of blood vessels. However, their long manufacturing time requiring >3 d limits their use in emergency situations.…”

Section: Introductionmentioning

confidence: 99%

Rapid and Accurate Manufacture of 3D Vascular Replicas with Smooth Inner Surfaces Using Wax‐Coated Molds

Lim

Hwang

Kim

2021

Adv Materials Technologies

Self Cite

View full text Add to dashboard Cite

3D vascular replicas are an economical and ethical training platform that can simulate endovascular intervention. During the manufacture of elaborate 3D vascular replicas through sacrificial molding, the surface of the 3D‐printed pristine molds should be smoothed because the 3D‐printed layered filament is transferred to the inner surface of the replicas. However, conventional smoothing methods using organic solvents take >3 d, thereby limiting the emergency use of 3D vascular replicas. This study demonstrates the rapid and accurate manufacture of 3D vascular replicas with a smooth inner surface using wax‐coated molds. The wax coating can smooth the surface of the 3D‐printed pristine molds in ≈30 s, reducing processing time by >3 d. In addition, the thin and even wax coating, except for structures with a radius of curvature less than 2.5 mm or diameter less than 3 mm, facilitates the manufacture of elaborate 3D vascular replicas. The resulting replicas represent an internal vascular structure with high transmittance (≈90%) and mechanical properties similar to those of blood vessels, including Young's modulus and friction coefficient. Thus, the prepared 3D vascular replicas using wax‐coated molds can be applied as endovascular simulators in emergency situations.

show abstract

Dip Coating: A New Dip Coating Method Using Supporting Liquid for Forming Uniformly Thick Layers on Serpentine 3D Substrates (Adv. Mater. Interfaces 24/2019)

Cited by 9 publications

References 0 publications

3D Vascular Replicas Composed of Elastomer–Hydrogel Skin Multilayers for Simulation of Endovascular Intervention

3D Vascular Replicas Composed of Elastomer–Hydrogel Skin Multilayers for Simulation of Endovascular Intervention

Embolization of Vascular Malformations via In Situ Photocrosslinking of Mechanically Reinforced Alginate Microfibers using an Optical‐Fiber‐Integrated Microfluidic Device

Rapid and Accurate Manufacture of 3D Vascular Replicas with Smooth Inner Surfaces Using Wax‐Coated Molds

Contact Info

Product

Resources

About