Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity

Gudasheva, T. A.; Konstantinopolsky, M. A.; Тарасюк, Алексей Валерьевич; Колик, Л. Г.; Середенин, С. Б.

doi:10.1134/s1607672919020121

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Zakusov Research1

Low‐molecular Mimetics Of Bdnf1

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2020

2022

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Cited by 3 publications

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“…The mimetic of BDNF loop 4, GSB-106, showed analgesic activity in hot plate tests and tail-flick test in rats at intraperitoneal administration at doses of 0.1 and 1.0 mg/kg within 0.5-48 h after injection. 139 Notably, the analgesic activity of morphine preserved no more than 3 h in the same tests. 140 The loop 2 mimetic GTS-201 activating MAPK/ERK only possessed weak analgesic activity, while the mimetic activating PI3K/AKT only was totally inactive.…”

Section: Zakusov Researchmentioning

confidence: 90%

See 1 more Smart Citation

Low‐molecular mimetics of nerve growth factor and brain‐derived neurotrophic factor: Design and pharmacological properties

Gudasheva

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Тарасюк

et al. 2020

Medicinal Research Reviews

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Section: Zakusov Researchmentioning

confidence: 90%

“…The mimetic of BDNF loop 4, GSB‐106, showed analgesic activity in hot plate tests and tail‐flick test in rats at intraperitoneal administration at doses of 0.1 and 1.0 mg/kg within 0.5–48 h after injection 139 . Notably, the analgesic activity of morphine preserved no more than 3 h in the same tests 140 .…”

Section: Low‐molecular Mimetics Of Bdnfmentioning

confidence: 96%