Dipeptidyl peptidase-4 activity, lipopolysaccharide, C-reactive protein, glucose metabolism, and gut peptides 3 months after bariatric surgery

The postprandial secretion of peptide YY1‐36 and 3‐36 in obesity is differentially increased after gastric bypass versus sleeve gastrectomy

“…After bariatric surgery DPP‐4 activity fell, and such a reduction in DPP‐4 activity would be expected to drive beneficial metabolic effects such as reduced degradation of incretins both in circulation and within pancreatic islets, as well as reductions in inflammation and insulin resistance within adipose tissue and the liver 23 . Although previous studies suggest that bariatric surgery does not seem to affect the abnormally increased plasma DPP‐4 activity, 25,34 our results may reflect the conversion of PYY 1‐36 to PYY 3‐36 via tissue DPP‐4 (e.g., pancreatic, intestine, liver, vascular endothelium) and may be a more sensitive marker of the effects of surgery and weight loss on the physiology of DPP‐4 than plasma enzyme activity. These suggestive but preliminary results will need confirmation in future studies.…”