Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes

Marfella, Raffaele; Sasso, Ferdinando Carlo; Rizzo, Maria Rosaria; Paolisso, Pasquale; Barbieri, Michelangela; Padovano, Vincenzo; Carbonara, Ornella; Gualdiero, Pasquale; Petronella, Pasquale; Ferraraccio, Franca; Petrella, Antonello; Canonico, Raffaele; Campitiello, Ferdinando; Corte, A Della; Paolisso, Giuseppe; Canonico, Silvestro

doi:10.1155/2012/892706

Cited by 72 publications

(67 citation statements)

References 32 publications

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“…Approximately 15% of diabetic patients are affected by a diabetic foot ulcer. It is a major health problem since it causes pain, suffering and poor life quality [7].…”

Section: Complications Of Diabetesmentioning

confidence: 99%

“…Its role in the regulation of cell adhesion, migration, apoptosis, angiogenesis and extracellular matrix degradation was previously confirmed. It was indicated that DPP IV/ CD26 plays a particularly relevant role in tissue regeneration where it was found to influence inflammatory processes and impacts the process of epithelialization of wounds [6,7,10].…”

Section: Dipeptidyl Peptidase Iv/molecule Cd26 (Dpp Iv/ Cd26)mentioning

confidence: 99%

“…Active GLP-1 is important as it stimulates the excretion of glucose-stimulated insulin, increases the biosynthesis of insulin, stimulates the growth and proliferation of beta cells, and inhibits the excretion of glucagon [2]. An important role of DPP IV/ CD26 inhibitors on decreasing proteasome activity was found in order to preserve angiogenic factors and angiogenesis at the wound site [7].…”

Section: Dpp Iv/cd26mentioning

confidence: 99%

“…Previous studies evidenced that GLP-1 improves the generation of the angiogenic factor VEGF in human pancreatic islet environment [21]. Likewise, increased GLP-1 concentrations reduce the activation of the proteasome activity induced by oxidative stress [7]. In hyperglycemic conditions, HIF-1α is destabilized and its function is impaired, leading to delayed wound healing.…”

Section: Biologically Important Molecules Related To Dpp Iv/ Cd26mentioning

confidence: 99%

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Wound Healing Process, Diabetes and Implications of Dipeptidyl Peptidase IV (DPP IV/CD26)

Pučar¹,

Kovač²,

Detel³

et al. 2017

J Tissue Sci Eng

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Dipeptidyl Peptidase IV or molecule CD26 (DPP IV/CD26) is a multifunctional protein, identified as a therapeutic target for type 2 diabetes, due to its ability to degrade incretins, insulin secretagogues. Delayed wound healing is a significant complication in diabetic patients that represents a major socio-economic health problem. It has been proposed that DPP IV/CD26 inhibition accelerates healing of chronic diabetic ulcers in those patients, through the induction of a histological pattern consistent with enhanced angiogenesis. Studies on mice models of diabetesdisturbed wound healing also suggested that the inhibition of DPP IV enzymatic activity may improve tissue regeneration processes. However, further research is needed to elucidate the role of DPP IV/CD26 in diabetic wound healing. The objective of this work was to discuss recent findings on the implications of DPP IV/CD26 in tissue regeneration and reparation in diabetic environment.

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“…Approximately 15% of diabetic patients are affected by a diabetic foot ulcer. It is a major health problem since it causes pain, suffering and poor life quality [7].…”

Section: Complications Of Diabetesmentioning

confidence: 99%

Section: Dipeptidyl Peptidase Iv/molecule Cd26 (Dpp Iv/ Cd26)mentioning

confidence: 99%

Section: Dpp Iv/cd26mentioning

confidence: 99%

Section: Biologically Important Molecules Related To Dpp Iv/ Cd26mentioning

confidence: 99%

See 2 more Smart Citations

Wound Healing Process, Diabetes and Implications of Dipeptidyl Peptidase IV (DPP IV/CD26)

Pučar¹,

Kovač²,

Detel³

et al. 2017

J Tissue Sci Eng

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“…(Gross & Nehme, 1999;Caiafa et al, 2011). Pacientes com história prévia de úlcera ou amputação têm elevado risco para o desenvolvimento de novas úlceras, infecção e gangrena, podendo culminar em amputação (Milman et al, 2001;Bortoletto et al, 2009;Marfella et al, 2012).…”

Section: Introductionunclassified

Importância do uso de plantas medicinais nos processos de xerose, fissuras e cicatrização na diabetes mellitus

Silva

Lopes

Monteiro

et al. 2015

Rev. bras. plantas med.

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RESUMO:Artigo de revisão que trata da importância do tratamento da xerose e de fissuras nos pés de pacientes com diabetes mellitus. Essas fissuras se não tratadas, constituem porta de entrada para infecções e podem resultar na formação de úlceras, que são a causa mais comum das amputações de extremidades de causa não traumática. Por isso a prevenção de fissuras nos pés de diabéticos é fundamental, já que a cicatrização é um processo complicado nesses pacientes, devido à hiperglicemia. Aborda sobre produtos usados no tratamento de xerose e fissuras e o crescente interesse de pesquisadores e do mercado no uso de fitoterápicos com esse objetivo.Palavras-chave: diabetes, fissuras, cicatrização de feridas, tratamento, plantas medicinais ABSTRACT: The importance of the use of medicinal plants in the process of xerosis, fissures and healing. A review article that deals with the importance of treating xerosis and fissures in the feet of patients with diabetes mellitus. These wounds can be a gateway to infections and may result in the formation of ulcers, if untreated. The ulcers are the most common cause for the amputations of extremities at non-traumatic cases. For this reason, the prevention of fissures in the feet of diabetic patientsis basal, since healing is a complicated process in this patients because of their hyperglycemia symptom. This article addresses the products employed in the therapy of xerosis and fissures, and also investigates the increasing interest of researchers and market in the application of phytotherapic medicines for this purpose. REVISÃO INTRODUÇÃOMundialmente, um número crescente de indivíduos portadores de diabetes mellitus (DM) tem sido registrado e as complicações crônicas da doença, como por exemplo, o pé diabético, representam grande importância clínica. No Brasil a DM atinge em torno de 7,6% da população entre 30 e 69 anos de idade, sendo que 50% dos pacientes desconhecem o diagnóstico e 24% não fazem qualquer tipo de tratamento (Gross & Nehme, 1999;Milman et al., 2001;Bortoletto et al., 2009).A cada seis anos cresce em 18% o número de homens com DM e cerca de 20% dos idosos com mais de 65 anos têm a doença. Fatores de risco como a obesidade, o envelhecimento, mau controle glicêmico, tabagismo e hipertensão arterial sistêmica (HAS) contribuem para esse crescimento, chegando a mais de 87,9 milhões de reais ao ano, o custo das internações hospitalares com a doença na rede pública brasileira (SBACVRJ, 2013). As complicações comuns da DM são as lesões crônicas nos vasos sanguíneos (vasculopatias) e nos nervos (neuropatias) afetando principalmente rins, retina, artérias, cérebro e nervos periféricos (Gross & Nehme, 1999;Bortoletto et al., 2009).Uma das principais causas de hospitalização de pacientes com DM é a amputação de membros inferiores, um fator de incapacidade, invalidez, aposentadoria precoce e morte que implica em altos custos financeiros. Geralmente, a amputação ocorre em decorrência das alterações vasculares e/ou neurológicas peculiares da doença, que são responsáveis pelo "pé ...

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IWGDF guidance on use of interventions to enhance the healing of chronic ulcers of the foot in diabetes

Game

Apelqvist

Attinger

et al. 2016

Diabetes Metabolism Res

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Recommendations1. Clean ulcers regularly with clean water or saline, debride them when possible in order to remove debris from the wound surface and dress them with a sterile, inert dressing in order to control excessive exudate and maintain a warm, moist environment in order to promote healing. (GRADE strength of recommendation: strong; quality of evidence: low) 2. In general, remove slough, necrotic tissue and surrounding callus with sharp debridement in preference to other methods, taking relative contraindications such as severe ischemia into account. (strong; low) 3. Select dressings principally on the basis of exudate control, comfort and cost. (strong; low) 4. Do not use antimicrobial dressings with the goal of improving wound healing or preventing secondary infection. (strong; moderate) 5. Consider the use of systemic hyperbaric oxygen therapy, even though further blinded and randomized trials are required to confirm its costeffectiveness, as well as to identify the population most likely to benefit from its use. (weak; moderate) 6. Topical negative pressure wound therapy may be considered in postoperative wounds even though the effectiveness and cost-effectiveness of the approach remain to be established. (weak; moderate) 7. Do not select agents reported to improve wound healing by altering the biology of the wound, including growth factors, bioengineered skin products and gases, in preference to accepted standards of good quality care. (strong; low) 8. Do not select agents reported to have an impact on wound healing through alteration of the physical environment, including through the use of electricity, magnetism, ultrasound and shockwaves, in preference to accepted standards of good quality care. (strong; low) 9. Do not select systemic treatments reported to improve wound healing, including drugs and herbal therapies, in preference to accepted standards of good quality care. (strong; low)

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Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes

Cited by 72 publications

References 32 publications

Wound Healing Process, Diabetes and Implications of Dipeptidyl Peptidase IV (DPP IV/CD26)

Wound Healing Process, Diabetes and Implications of Dipeptidyl Peptidase IV (DPP IV/CD26)

Importância do uso de plantas medicinais nos processos de xerose, fissuras e cicatrização na diabetes mellitus

IWGDF guidance on use of interventions to enhance the healing of chronic ulcers of the foot in diabetes

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