Dipeptidyl Peptidase-4 Inhibitor Decreases Allograft Vasculopathy Via Regulating the Functions of Endothelial Progenitor Cells in Normoglycemic Rats

Lin, Feng Yen; Shih, Chuen Ming; Huang, Chun Yao; Tsai, Yi Tin; Loh, Shih‐Hurng; Li, Chi Yuan; Lin, Ching‐Yih; Lin, Yi Wen; Tsai, Chien‐Sung

doi:10.1007/s10557-020-07013-w

Cited by 10 publications

(5 citation statements)

References 49 publications

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“…In this study, although we only explored the effects of PAW on OAT-induced vasculopathy and obtained surprising results, we continue to study its detailed mechanism of action. Previous, we have demonstrated that dipeptidyl peptidase-4 (DPP-4) inhibitor lowers OAT vasculopathy in rats through direct increase in GLP-1 activity, and regulates SDF-1α levels and EPCs function [ 69 ]. We are the first group to provide new prevention and treatment strategies for DPP-4 inhibitors in chronic rejection-induced vasculopathy.…”

Section: Discussionmentioning

confidence: 99%

Transferring Plasmon Effect on a Biological System: Expression of Biological Polymers in Chronic Rejection and Inflammatory Rat Model

et al. 2021

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The plasmon-activated water (PAW) that reduces hydrogen bonds is made of deionized reverse osmosis water (ROW). However, compared with ROW, PAW has a significantly higher diffusion coefficient and electron transfer rate constant in electrochemical reactions. PAW has a boiling point of97 °C and specific heat of0.94; the energy of PAW is also 1121 J/mol higher than ordinary water. The greater the force of hydrogen bonds between H2O, the larger the volume of the H2O cluster, and the easier it is to lose the original characteristics. The hydrogen bonding force of PAW is weak, so the volume of its cluster is small, and it exists in a state very close to a single H2O. PAW has a high permeability and diffusion rate, which can improve the needs of biological applications and meet the dependence of biological organisms on H2O when performing physiological functions. PAW can successfully remove free radicals, and efficiently reduce lipopolysaccharide (LPS)-induced monocytes to release nitric oxide. PAW can induce expression of the antioxidant gene Nrf2 in human gingival fibroblasts, lower amyloid burden in mice with Alzheimer’s disease, and decrease metastasis in mice grafted with Lewis lung carcinoma cells. Because the transferring plasmon effect may improve the abnormality of physiological activity in a biological system, we aimed to evaluate the influence of PAW on orthotopic allograft transplantation (OAT)-induced vasculopathy in this study. Here, we demonstrated that daily intake of PAW lowered the progression of vasculopathy in OAT-recipient ACI/NKyo rats by inhibiting collagen accumulation, proliferation of smooth muscle cells and fibroblasts, and T lymphocyte infiltration in the vessel wall. The results showed reduced T and B lymphocytes, plasma cells, and macrophage activation in the spleen of the OAT-recipient ACI/NKyo rats that were administered PAW. In contrast to the control group, the OAT-recipient ACI/NKyo rats that were administered PAW exhibited higher mobilization and levels of circulating endothelial progenitor cells associated with vessel repair. We use the transferring plasmon effect to adjust and maintain the biochemical properties of water, and to meet the biochemical demand of organisms. Therefore, this study highlights the therapeutic roles of PAW and provides more biomedical applicability for the transferring plasmon effect.

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Section: Discussionmentioning

confidence: 99%

Transferring Plasmon Effect on a Biological System: Expression of Biological Polymers in Chronic Rejection and Inflammatory Rat Model

et al. 2021

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“…The allograft OAT procedure has been demonstrated in a previous study. 25 For XTP, approximately 1 cm of the ScCO 2 -DFA or SDS-DFA was anatomized with 7-O silk sutures onto the abdominal aorta of ACI/NKyo rats. The OAT and XTP procedures were completed within 80 min.…”

Section: Methodsmentioning

confidence: 99%

Supercritical carbon dioxide-decellularized arteries exhibit physiologic-like vessel regeneration following xenotransplantation in rats

Sung

Yang

et al. 2023

Biomater. Sci.

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“…However, aortic transplantation in the PVG/Seac rats to ACI/NKyo rats model is more appropriate for studies regarding chronic rejection-induced allograft vasculopathy as the ACI/NKyo rat develops a weak acute rejection response against the graft aorta from the PVG/Seac rat. Lin et al transplanted a thoracic aorta from a PVG/Seac rat to the abdominal aorta of an ACI/NKyo rat to study the endothelial mesenchymal transition as a mechanism that induces CAV and identify treatments for CAV by monitoring cell-cell interactions [25][26][27]. In addition, the authors used this method to investigate molecular pathways that may have protective effects against chronically-rejected grafts [27].…”

Section: Heterotopic Aortic Transplantation In Ratsmentioning

confidence: 99%

Animal Models for Heart Transplantation Focusing on the Pathological Conditions

et al. 2023

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Cardiac transplant recipients face many complications due to transplant rejection. Scientists must conduct animal experiments to study disease onset mechanisms and develop countermeasures. Therefore, many animal models have been developed for research topics including immunopathology of graft rejection, immunosuppressive therapies, anastomotic techniques, and graft preservation techniques. Small experimental animals include rodents, rabbits, and guinea pigs. They have a high metabolic rate, high reproductive rate, small size for easy handling, and low cost. Additionally, they have genetically modified strains for pathological mechanisms research; however, there is a lacuna, as these research results rarely translate directly to clinical applications. Large animals, including canines, pigs, and non-human primates, have anatomical structures and physiological states that are similar to those of humans; therefore, they are often used to validate the results obtained from small animal studies and directly speculate on the feasibility of applying these results in clinical practice. Before 2023, PubMed Central® at the United States National Institute of Health’s National Library of Medicine was used for literature searches on the animal models for heart transplantation focusing on the pathological conditions. Unpublished reports and abstracts from conferences were excluded from this review article. We discussed the applications of small- and large-animal models in heart transplantation-related studies. This review article aimed to provide researchers with a complete understanding of animal models for heart transplantation by focusing on the pathological conditions created by each model.

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Dipeptidyl Peptidase-4 Inhibitor Decreases Allograft Vasculopathy Via Regulating the Functions of Endothelial Progenitor Cells in Normoglycemic Rats

Cited by 10 publications

References 49 publications

Transferring Plasmon Effect on a Biological System: Expression of Biological Polymers in Chronic Rejection and Inflammatory Rat Model

Transferring Plasmon Effect on a Biological System: Expression of Biological Polymers in Chronic Rejection and Inflammatory Rat Model

Supercritical carbon dioxide-decellularized arteries exhibit physiologic-like vessel regeneration following xenotransplantation in rats

Animal Models for Heart Transplantation Focusing on the Pathological Conditions

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