Diphenhydramine‐selective plastic membrane sensor and its pharmaceutical applications

Erdem, Arzum; Ozsoz, Mehmet; Kirilmaz, Levent; Kılınc, Emrah; Dalbastı, Tayfun

doi:10.1002/elan.1140091213

Cited by 13 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The performance of DPH-selective electrodes using various ionpair complexes of DPH were compared by Erdem et al [69]. The investigated ion-pairing agents were tetraphenylborate (TPB), phosphotungstate (PT) and reineckate (RN).…”

Section: Diphenhydraminementioning

confidence: 99%

A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs

Thapliyal

Patel

Karpoormath

et al. 2015

Talanta

View full text Add to dashboard Cite

Section: Diphenhydraminementioning

confidence: 99%

A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs

Thapliyal

Patel

Karpoormath

et al. 2015

Talanta

View full text Add to dashboard Cite

“…The literature survey disclosed, titrimetric methods for the estimation of DPH has been described in European Pharmacopoeia 3 and British Pharmacopoeia 4 where has HPLC has been described in United States Pharmacopoeia 5 . Several unofficial analytical techniques such as fluorometry 5 , spectrophotometry 7, 8, 9, 10, 11, 12 and electrochemical analysis 13,14 has also been reported for the estimation of DPH in pharmaceutical preparations. Atomic absorption spectroscopy 15,16 and capillary electrophoresis 17,18,19 was also used previously.…”

Section: Introduction: Diphenhydramine (Dph)mentioning

confidence: 99%

Untitled

2019

IJPSR

View full text Add to dashboard Cite

The current work defines development of a simple, rapid and precise method based on gas chromatography coupled with Flame Ionization Detector (GC-FID) for the quantitative estimation of diphenhydramine (DPH) present in the marketed formulations following the principles of green analytical chemistry. The analysis was performed using Zebron Phase: ZB-DRUG-1 column with Nitrogen as a carrier gas having a flow rate of 1 ml/min. The injection volume was 1 µL and with the split ratio of 1:10. The retention time of the drug was found to be 4.5 minutes. The developed method was validated according to the ICH guidelines, proving the method to be sensitive towards the analyte with accuracy (mean recovery = 98%), linearity in the range of 2-10 µg/ml (r 2 0.993), precision (intraday = 1.118% RSD, interday = 1.16 % RSD), LOD 0.2 µg/ml and LOQ 0.5 µg/ml. The degradation study showed that the drug remains stable in acid, base, neutral, oxidation, and photolytic method. The developed method can be effectively employed for the day to day analysis of DPH in pure and marketed formulations by industries and not so well equipped laboratories, as the method employs direct analysis of DPH without any derivatization technique by gas chromatography with simple flame ionization detection. QUICK RESPONSE CODE

show abstract

“…CPM binds to H 1 histamine receptor, which blocks the histamine action, which leads to relief of the negative symptoms. Different methods are available for the determination of DPH and CPM in raw as well as in pharmaceutical preparations including titrimetric analysis 3,5 , electrochemical analysis, chromatographic and spectrophotometric methods 6,17 .…”

Section: Introductionmentioning

confidence: 99%

Visible Spectrophotometric determination of Chlorpheniramine maleate and Diphenhydramine hydrochloride in raw and dosage form using Potassium permanganate

Bratty¹

2016

Orient. J. Chem

View full text Add to dashboard Cite

Two simple, rapid and sensitive spectrophotometric methods developed for Chlorpheniramine Maleate (CPM) and Diphenhydramine Hydrochloride (DPH) determination in pure and pharmaceutical preparation using Potassium Permanganate. The solvent system used was potassium permanganate. The method developed by adding a known amount of permanganate to CPM and DPH in acid and alkaline medium, the unreacted permanganate was determined at 550 nm; method A and bluish green colour of Manganate at 610 nm; method B. In method A decrease in absorbance or method B increase in absorbance as concentrations of CPM and DPH was measured. Beers law was obeyed at a range of 2.5 to 20 µg / ml in both the methods A and B. The method was validated as per International Council for Harmonisation guideline. The proposed methods were effectively used for the determination of CPM and DPH in commercially available syrup. The average percentages of recoveries of CPM were 99.20 ± 1.29% (method A), 100.6% ± 1.43% (method B); DPH 98.50 ± 1.29% (method A) and 100.20 ± 1.43% (method B). The methods were efficiently validated and used for quantitative determination of Chlorpheniramine maleate and Diphenhydramine Hydrochloride in pure and syrup preparations.

show abstract

Diphenhydramine‐selective plastic membrane sensor and its pharmaceutical applications

Cited by 13 publications

References 11 publications

A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs

A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs

Untitled

Visible Spectrophotometric determination of Chlorpheniramine maleate and Diphenhydramine hydrochloride in raw and dosage form using Potassium permanganate

Contact Info

Product

Resources

About