Diphenyl diselenide decreases the prevalence of vacuous chewing movements induced by fluphenazine in rats

Fachinetto, Roselei; Villarinho, Jardel Gomes; Wagner, Caroline; Pereira, Romaiana Picada; Puntel, Robson Luiz; Paixão, Márcio W.; Braga, Antônio L.; Calixto, João B.; Rocha, João Batista Teixeira da; Ferreira, Juliano

doi:10.1007/s00213-007-0831-y

Cited by 23 publications

(3 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, several studies using inorganic and organic forms of Se have demonstrated their protective effects against oxidative stress in disease models of diabetes (Kiersztan et al, 2007), cancer (Steinbrenner and Sies, 2009) and neurological disorders (Atif et al, 2008). In fact, different classes of Se compounds such as Ebselen, a lipid soluble seleno‐organic compound, (Porciúncula et al, 2001), as well as other organic Se (Nogueira et al, 2004; Fachinetto et al, 2007) and inorganic Se such as sodium selenite (Atif et al, 2008) exhibit a neuroprotective role via their antioxidant properties, making Se an essential trace element.…”

Section: Introductionmentioning

confidence: 99%

Dietary selenium addition improves cerebrum and cerebellum impairments induced by methimazole in suckling rats

Amara

Fetoui

Guermazi

et al. 2009

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

The aim of this study is to investigate the improving effects of selenium (Se) on cerebrum and cerebellum impairments induced by methimazole (MMI) in suckling rats. Animals were randomly divided into four groups of six each: group I served as control which received standard diet; group II received only MMI (250 mg L(-1)(,) orally); group III received both MMI (250 mg L(-1), orally) and Se (0.5 mg kg(-1) of diet); group IV served as a positive control and received Se (0.5 mg kg(-1) of diet) as sodium selenite (Na(2)SeO(3)). Treatments were started from the 14th day of pregnancy until day 14 after delivery. In the MMI-treated group, plasma-free thyroid hormone levels (FT(3) and FT(4)), protein, DNA and RNA contents in cerebrum and cerebellum decreased when compared to control. Co-treatment with Se ameliorated these parameters. In the MMI-treated group, antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) significantly decreased, while malonaldialdehyde (MDA) levels in cerebrum and cerebellum increased. Co-administration of Se through the diet restored these parameters to near normal values. The biochemical modifications are correlated histologically with the abnormal development of an external granular layer, indicating a delay of granular cells migration towards the molecular layer in the MMI-treated group. Our results showed that Se improved cerebrum and cerebellum MMI-induced damages in suckling rats. Moreover, we concluded that Se is an important neuroprotective element that may be used as a dietary supplement against brain impairments.

show abstract

Section: Introductionmentioning

confidence: 99%

Dietary selenium addition improves cerebrum and cerebellum impairments induced by methimazole in suckling rats

Amara

Fetoui

Guermazi

et al. 2009

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

“…The treatment was carried out over the course of 6 months and was based on previous studies [4,29,[41][42][43].…”

Section: Methodsmentioning

confidence: 99%

“…The simplest of diaryl diselenides, diphenyl diselenide, has been shown to be even more active as a glutathione peroxidase mimic [27] and less toxic to rodents than ebselen [28]. Recently, data from our laboratory have indicated that diphenyl diselenide decreased the prevalence of vacuous chewing movements induced by long‐term treatment with fluphenazine in rats [29]. Furthermore, diphenyl diselenide has a protective role in a variety of experimental models associated with the overproduction of free radicals in the brain, liver and kidney [26,30–32].…”

mentioning

confidence: 99%

Chronic Treatment with Fluphenazine Alters Parameters of Oxidative Stress in Liver and Kidney of Rats

Corte¹,

Fachinetto²,

Puntel³

et al. 2009

Basic &Amp; Clinical Pharmacology &Amp; Toxicology

Self Cite

View full text Add to dashboard Cite

The aim of this study was to assess the toxic effects of chronic exposure to fluphenazine in liver and kidney of rats, as well as the possible protective effect of diphenyl diselenide on the fluphenazine-induced damage. Long-term treatment with fluphenazine caused an increase in lipid peroxidation levels in liver and kidney homogenates. Diphenyl diselenide treatment did not affect δ -aminolevulinate dehydratase ( δ -ALA-D) activity, but fluphenazine alone or in combination with diphenyl diselenide showed an inhibitory effect on δ -ALA-D activity in liver. Diphenyl diselenide plus fluphenazine treatment increased the reactivation index of hepatic δ -ALA-D by approximately 80%. Superoxide dismutase activity decreased in liver of rats treated with fluphenazine alone. The combined treatment with fluphenazine and diphenyl diselenide was able to ameliorate superoxide dismutase activity in liver of rats. Catalase activity was augmented in liver from rats treated with fluphenazine, and this increase was prevented when diphenyl diselenide was co-administered. Taken together, these results indicate that the association of diphenyl diselenide with fluphenazine could protect the liver from lipid peroxidation and ameliorate superoxide dismutase and catalase activities. Moreover, our data point to the relationship between the oxidative stress and fluphenazine treatment in liver and kidney of rats.

show abstract

Organoselenium and organotellurium compounds: Toxicology and pharmacology

Nogueira

Rocha

2011

Patai's Chemistry of Functional Groups

View full text Add to dashboard Cite

In the last three decades, the interest in the field of synthesis and reactivity of organoselenium and organotellurium compounds has increased; particularly, in view of the observations that they can exhibit important biological activities. The data presented in this chapter clearly indicate the potential pharmacological and therapeutic uses of organoselenium and organotellurium compounds. Indeed, these classes of molecules exhibit a variety of interesting biological effects, namely antioxidant properties, which can account for their in vitro and in vivo beneficial effects in a wide range of models of different human pathologies. We can conclude that the future of “medicinal chemistry“ of organoselenium and organotellurium compounds will depend on the rational development of new molecules, which can be guided by chemical and biological approaches. Moreover, the structure‐activity relationship for a given class of organoselenium or organotellurium compounds should be used as a toll for screening molecules with high probability of exhibiting low toxicity and high pharmacological activity in mammals.

show abstract

Diphenyl diselenide decreases the prevalence of vacuous chewing movements induced by fluphenazine in rats

Abstract: Our data suggest that the reduction in dopamine transport can be a possible mechanism related to the maintenance of VCMs in rats. Moreover, diphenyl diselenide seems to be a promising pharmacological agent in the reduction in the prevalence of VCMs in rats.

Cited by 23 publications

References 68 publications

Dietary selenium addition improves cerebrum and cerebellum impairments induced by methimazole in suckling rats

Dietary selenium addition improves cerebrum and cerebellum impairments induced by methimazole in suckling rats

Chronic Treatment with Fluphenazine Alters Parameters of Oxidative Stress in Liver and Kidney of Rats

Organoselenium and organotellurium compounds: Toxicology and pharmacology

Contact Info

Product

Resources

About