Diphenyl diselenide modulates antioxidant status, inflammatory and redox-sensitive genes in diesel exhaust particle-induced neurotoxicity

Recent Progress in Synthetic and Biological Application of Diorganyl Diselenides

“…These mechanisms include activating the Nrf2/ Keap1 signaling pathway in a streptozotocin-induced renal dysfunction in rats, [293] inhibiting NFkB and MAPK signaling pathways in lipopolysaccharide (LPS)-induced inflammation in rat glomerular mesangial (HBZY-1) cells, [294] suppressing proinflammatory M1 microglia-mediated neuroinflammation in amyotrophic lateral sclerosis (ALS) mouse model [292] and in a model of neurotoxicity induced by a diesel-exhaust particle (DEP). [295] Nociception is characterized as the sensory detection of tissue damage by specialized transducers, which can be impacted by inflammatory and neural changes. [296] Diphenyl diselenide effectively modulated the levels of inflammatory proteins in the cerebral cortex and alleviated thermal hypernociception in female mice exposed to bisphenol A (BPA).…”

“…[289‐292] Diphenyl diselenide, an extensively researched selenium‐containing compound, has been demonstrated to mitigate inflammation by various mechanisms. These mechanisms include activating the Nrf2/Keap1 signaling pathway in a streptozotocin‐induced renal dysfunction in rats, [293] inhibiting NFκB and MAPK signaling pathways in lipopolysaccharide (LPS)‐induced inflammation in rat glomerular mesangial (HBZY‐1) cells, [294] suppressing proinflammatory M1 microglia‐mediated neuroinflammation in amyotrophic lateral sclerosis (ALS) mouse model [292] and in a model of neurotoxicity induced by a diesel‐exhaust particle (DEP) [295] …”

Click Chemistry of Selenium Dihalides: Novel Bicyclic Organoselenium Compounds Based on Selenenylation/Bis-Functionalization Reactions and Evaluation of Glutathione Peroxidase-like Activity

“…Organoselenium compounds have proven themselves as versatile and efficient intermediates and synthons for modern organic synthesis [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. The selenium-containing reagents and selenium-mediated reactions are used in the synthesis of many useful products, including the total synthesis of important biologically active molecules [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ].…”