Diphenyl(vinyl)phosphine Oxide

Gold-Catalyzed Access to Isophosphinoline 2-Oxides

“…It is also envisioned that the vinylphosphine oxide moiety may act as a new covalent inhibitor scaffold. The electrophilic character of such a functional group was thoroughly illustrated in the literature, and it was proved to react with a broad range of nucleophiles . The low conjugation of the alkene moiety with the phosphoryl group makes them less electrophilic compared to the parent carbonyl derivatives …”