Diphenylcyclopropenone-Induced Vitiligo in a Patient with Alopecia Universalis

Riad, Hassan; Mannai, Haya Al; Mansour, Khalid; Qaatri, Khalifa Al; Dosari, Sharifa Al; Obaidaly, Amina Al; Sultan, Emad

doi:10.1159/000354767

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…However, all repigmentation disappeared on stopping the treatment. In contrast, vitiligo as an adverse event has been reported following contact sensitizers [150][151][152][153][154][155][156][157][158][159][160]. Thus, topical immunotherapy has been considered as a depigmentation treatment option for patients with extensive vitiligo [161,162].…”

Section: Vitiligomentioning

confidence: 99%

Use of Contact Immunotherapy in the Treatment of Skin Diseases Other than Alopecia Areata

Lai

Tsai

2022

Dermatol Ther (Heidelb)

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For decades, contact immunotherapy with dinitrochlorobenzene, diphencyprone, and squaric acid dibutylester has played an important role in both clinical practice and scientific research. It is listed as the first-line treatment for extensive alopecia areata and was more recently approved for melanoma treatment as an orphan drug in the USA. Moreover, owing to the relative low cost and safety, topical immunotherapy has also been used in many infectious, neoplastic, and inflammatory dermatological diseases. It is especially valuable in vulnerable groups, for cosmetic/pain sensitive areas, or for multiple lesions. In this review, we summarize the current evidence supporting the use of contact immunotherapy for treatment of skin diseases, from articles collected from PubMed database. Owing to space limitation and already numerous studies focusing on alopecia areata, we include only skin diseases other than alopecia areata. In addition to diseases that have been reported to be treated by contact immunotherapy, the hypothesized mechanism, prognosis prediction, efficacy, and safety of these topical agents are discussed.

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Section: Vitiligomentioning

confidence: 99%

Use of Contact Immunotherapy in the Treatment of Skin Diseases Other than Alopecia Areata

Lai

Tsai

2022

Dermatol Ther (Heidelb)

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“…Other therapies include anthralin, azathioprine [77], cyclosporine, methotrexate, sulfasalazine [51], adalimumab [78], tofacitinib, and ruxolitinib [79][80]. Weight gain, avascular necrosis, hypertension, diabetes, sleep problems, mood swings, acne, allergy sensitivity, abnormal hair colouring, and even disorders like vitiligo, which can be induced by diphenylcyclopropenone, should all be carefully monitored [51,[81][82].…”

Section: Other Treatment Optionsmentioning

confidence: 99%

Review on Alopecia: Disease and Characterstics, Clinical Evaluation, Psychological Impact & Available Treatment Options

Sheikh

Ibrahim

Shahid³

et al. 2022

JPRI

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Alopecia Areata (AA) is a frequent recurrent dermatological autoimmune illness that causes patchy regions of hair loss on the scalp and/or body. It can afflict people of any age or skin type, and it affects both men and women. It is necessary to develop new diagnostic procedures. Scalp dermatoscopy is a potential new technique for diagnosing scalp and hair diseases that may be difficult to diagnose otherwise. In adults, high-potency topical corticosteroids (TCs) such as 0.05 percent clobetasol propionate in different formulations or 0.25 percent desoximetasone cream are often used, with response rates of around 47 percent and 60%, respectively. Individuals with stable conditions can benefit from CI therapy provided at home, which can be just as safe and effective as CI therapy administered in a clinic setting.

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“…Once AA becomes chronic, hair follicles often stay in a protracted telogen phase with no discernible attempt to revert to an anagen growing phase [10,11] . Alopecia areata frequently occurs in association with other autoimmune disorders such as vitiligo, thyroid disease, type 1 diabetes mellitus, pernicious anemia, Addison's disease, lupus erythematosus, atopic dermatitis, and psoriasis [12][13][14][15] . A hallmark of active alopecia areata is the presence of peribulbar lymphocytes around the bulb region of anagen hair follicles upon histopathological examination [10] .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Trichloroacetic Acid in Patients with Alopecia Areata: A Clinico-Histopathological Study

Anter,

Zaky,

Nouh

et al. 2023

International Journal of Medical Arts

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Article informationBackground: Alopecia areata is an autoimmune disorder caused by a breakdown in the follicular immune privilege system, resulting in non-scarring hair loss. Many therapeutic options have been tested with variable results. Aim of the work:To assess the efficacy of trichloroacetic acid [TCA] 35% in patients of alopecia areata. Patients and Methods:This prospective cross-sectional study included 40 patients recruited from department of dermatology and venereology, Al-Hussein hospital.Every patient was treated by 3 sessions of TCA 35% with one-month intervals. The assessment was done by clinical, trichoscopy, and histopathological examination. Results:The study included 40 patients, 22 males [55%] and18 females [45%]. The mean age of studied patients was 25.6 ± 8.6 years with a minimum age of 16 years and a maximum age of 50 years. The duration of the disease ranged between 2 months and 10 years with a mean duration of 2.7 ± 2.5 years. Thirty patients [75%] showed improvement at the end of TCA sessions. Conclusion:Based on our findings, topical application of TCA 35% is a safe and effective treatment option for patients with alopecia areata. Moreover, it can be used in wide areas of the scalp and cases of alopecia totalis.

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Diphenylcyclopropenone-Induced Vitiligo in a Patient with Alopecia Universalis

Cited by 6 publications

References 23 publications

Use of Contact Immunotherapy in the Treatment of Skin Diseases Other than Alopecia Areata

Use of Contact Immunotherapy in the Treatment of Skin Diseases Other than Alopecia Areata

Review on Alopecia: Disease and Characterstics, Clinical Evaluation, Psychological Impact & Available Treatment Options

Efficacy of Trichloroacetic Acid in Patients with Alopecia Areata: A Clinico-Histopathological Study

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