Abstract:After a decade-long resurgence, including a large cutaneous diphtheria outbreak in Washington State, the diphtheria incidence rate in the United States reached its lowest recorded level ever in 1980-two patients (0.01 case per million). Mortality paralleled the decline in incidence rate. Only 143 of the 3,141 US counties reported noncutaneous diphtheria patients during 1971-81; most were located in the West. The highest attack rates were experienced by children less than 15 years old (0.8 case per million) … Show more
“…The reasons for the reduction of the number of tox-carrying C. diphtheriae strains in the NT are unclear, although it has been postulated that tox may be lost from organisms in highly immunized populations (3). The toxin gene is carried on a bacteriophage, but the toxin is a nonessential protein for both the phage and its lysogenic host bacterium (13).…”
Corynebacterium diphtheriae is commonly isolated from cutaneous skin lesions in the Northern Territory of Australia. We prospectively assessed 32 recent isolates from infected skin lesions, in addition to reviewing 192 isolates collected over 5 years for toxin status. No isolates carried the toxin gene. Toxigenic C. diphtheriae is now a rare occurrence in the Northern Territory.
“…The reasons for the reduction of the number of tox-carrying C. diphtheriae strains in the NT are unclear, although it has been postulated that tox may be lost from organisms in highly immunized populations (3). The toxin gene is carried on a bacteriophage, but the toxin is a nonessential protein for both the phage and its lysogenic host bacterium (13).…”
Corynebacterium diphtheriae is commonly isolated from cutaneous skin lesions in the Northern Territory of Australia. We prospectively assessed 32 recent isolates from infected skin lesions, in addition to reviewing 192 isolates collected over 5 years for toxin status. No isolates carried the toxin gene. Toxigenic C. diphtheriae is now a rare occurrence in the Northern Territory.
“…In the 1970s, nearly 1,300 cases of diphtheria in the United States (5) and 444 in Canada (3,6,9,19) were reported. Since the mid-1980s, the number of cases in both countries has declined to fewer than 50 (2,4,11,20).…”
Molecular characterization of 53 U.S. and Canadian Corynebacterium diphtheriae isolates by multilocus enzyme electrophoresis, ribotyping, and random amplified polymorphic DNA showed that strains with distinct molecular subtypes have persisted in the United States and Canada for at least 25 years. These strains are endemic rather than imported from countries with current endemic or epidemic diphtheria
“…It was claimed m the medical literature that the spread of diphtheria in the community is prevented if 70-80% or more of the population is immune 8 . A recent WHO meeting concluded that to achieve the elimination of diphtheria, a minimum immunization coverage rate of 90% in children and 75% in adults is required 15 .…”
Section: Immunity To Diphtheria In the Populationmentioning
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