Diphyllin fromHaplophyllum alberti-regelii, H. bucharicum, andH. perforatum

Abstract

on Chroma~on N-AW, at i column temperature o~ 202°C and ~ p=aao~ra o~ ~h~ =a==i~ ~6 (hsllum) o~ 0,7 kg~/cm', and also a 1,2 m ~ 3 mm column ~illed wi~h ~% SE-30 on Chroma~ou N-AW at a column =empera~ure of 220°C and a hellum prsosure of 0.65 kg£/c~ i. 0n the polar phase, the by-product issued as a slngle peak with methyl palmitate, exaggerating i~s true amount, and on the nonpolar phase i~ was eluted together with the solvent.

Screening of 14 alkaloids isolated from Haplophyllum A. Juss. for their cytotoxic properties

“…Previous phytochemical analysis of various Uzbek Haplophyllum species has revealed the presence of lignans (Nesmelova et al, 1983), coumarins (Batirov et al, 1982;Yuldashev, 2002), flavonoids (Yuldashev, 2002) and several classes of alkaloids: quinolones (Akhmedjanova et al, 1980;Bessonova, 2000); furoquinolines (Akhmedjanova et al, 1986); dihydrofuroquinolines (Yunusov and Sidyakin, 1955;Akhmedjanova et al, 1980); tetrahydrofuroquinolines (Faizutdinova et al, 1968), and pyranoquinolones (Akhmedjanova et al, 1976).…”

In VitroAntileishmanial Activity of Diphyllin Isolated fromHaplophyllum bucharicum

“…Diphyllin was isolated from dried ground aerial parts according to a previously described protocol [11] (yield: 0.1 % of the dry plant weight). M.p.…”

Lignans and Their Derivatives from Plants as Antivirals

“…Diphyllin is a natural component of plants with a naphthalene and one hydroxyl lignans [48]. It exists in Haplophyllum alberti-regelii, H. bucharicum, and H. perforatum (Rutaceae) [49]. It showed broad- ATG was initially isolated from Arctium lappa L. (Compositae).…”

“…The root of Isatis indigotica Fort is a very famous antiviral traditional medicine in China and is Diphyllin is a natural component of plants with a naphthalene and one hydroxyl lignans [48]. It exists in Haplophyllum alberti-regelii, H. bucharicum, and H. perforatum (Rutaceae) [49]. It showed broad-spectrum antiviral activity as a potent vacuolar ATPase (V-ATPase) inhibitor [50].…”