Diprenylated chalcones and other constituents from the twigs of Dorstenia barteri var. subtriangularis

Ngameni, Barthelemy; Ngadjui, Bonaventure T.; Folefoc, Gabriel N.; Watchueng, Jean; Abegaz, Berhanu M.

doi:10.1016/j.phytochem.2003.10.021

Cited by 27 publications

(19 citation statements)

References 5 publications

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“…Furano-chalcones (293-298) have been isolated only from species of the Leguminosae family. Dihydrofurano derivatives with 1-hydroxy-1-methylelthyl substituent [305 (flemistrictin E), 306, 307, 310 (bartericin C), 311 (paratocarpin F), 312 (licoagrochalcone D) and 313 (paratocarpin G)] have been isolated from Flemingia stricta (Subrahmanyam et al 1982), A. keiskei (Shimomura et al 2013), Dorstenia barteri (Ngameni et al 2004), Glycirrhiza glabra (Li et al 2000) and P. venenosa (Hano et al 1995b). Two dihydrofurano chalcones, xanthokeismin B (314) with 1,5-dihydroxy-1,5-dimethylhex-3-enyl, and xanthokeismin C (315) with 1,4-dihydroxy-1,5-dimethylhex-5-enyl substituent, were isolated from A. keiskei (Aoki et al 2008).…”

Section: Chalconesmentioning

confidence: 99%

Naturally occurring chalcones and their biological activities

2014

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The aim of this review is to summarize the various naturally occurring chalcone compounds which have been isolated from different plants. Chalcones considered as obligate intermediated in flavonoid biosynthesis but they do not accumulate to appreciable degree in most plants. The largest number of natural chalcones has been isolated from species of the Leguminosae, Asteraceae and Moraceae families. Chalcone accumulating plants have often been used in traditional medicine and chalcones have therefore been studied and reported to possess many beneficial biological effects including anti-inflammatory, antimicrobial, antifungal, antioxidant, cytotoxic, antitumor and chemopreventive activities. Previously published reviews on this topic survey the biological activities of natural and synthetic chalcones but there are no comprehensive contributions on occurrence and biological activities of natural chalcones. The present study provides an overview of hydroxy or/and methoxy-substituted chalcones, methylated, prenylated, geranylated and other monomeric derivatives, chromeno-and furanochalcones, dimeric chalcones and dihydrochalcone derivatives focusing on their biosynthesis, natural sources and biological activities. On the basis of 608 references, this review covers the phytochemistry and biological activity of natural chalcones, describing 646 compounds have been appeared in the literature since 1975. The summary is aimed to initiate further pharmacobotanical, biotechnological and medicinal studies on the field of chalcone research.

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Section: Chalconesmentioning

confidence: 99%

Naturally occurring chalcones and their biological activities

2014

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“…This indication was very useful information for future selection of antibiotics of reference for comparative studies with antibacterial agents from plants. The study of anti-bacterial agents from plant agents is a progressive research which aims at developing new chemical entities from plant (Ngameni et al, 2007). With the increasing bacterial resistance problems which poses serious problems, especially within our overcrowded hospital centres (nosocomial infections), and the use of cheap drugs with less active principle, there is the need for new alternative drug entities from plant material (Nicolle, 2008).…”

Section: Gram-positive Bacteriamentioning

confidence: 99%

“…Research has been carried out by (Kuete et al, 2007a;Ngameni et al, 2007) on the antimicrobial properties on many genus of Dorstenia but findings have very little studies on the antibacterial properties of D. Mannii.…”

Section: Introductionmentioning

confidence: 99%

In-vitro evaluation of the anti-bacterial properties of crude extracts of Dorstenia mannii (Moraceae)

Fokunang¹,

Mejane²,

Noumie³

et al. 2012

J. Microbiol. Antimicrob.

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Bacterial resistance to classical antibiotics nowadays is becoming a health concern in Cameroon. Patients suffering from bacteria attack spend money to carry out laboratory tests for effective diagnosis, with very little positive results. This is due to the fact that most of our hospitals lack the up to date laboratory equipments, to detect the real antibiotic that will kill a particular bacterium. This has led to more patients spending a lot of money on bacterial infection treatment, and some even end up dying with the disease. It is on this basis that this work was designed to research the antibacterial properties of the extracts namely crude extract, hexane-acetate 25%, hexane-acetate 50%, hexaneacetate 75%, hexane, acetate and methanol of the leaves of Dorstenia mannii, a plant that is readily available from our natural environment at little or no cost. These extracts were tested on the following bacteria species namely; Gram-negative bacteria; Enterobacter aerogenes, Escherichia coli, Klebsiella sp., Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enterica; Gram-positive bacteria; Staphylococcus aureus and Bacillus sp. After some laboratory analysis using the antibiogramme sensitivity test, it was discovered that the extracts of the leaves of D. mannii were only sensitive on three of the eight bacteria used which were, E. coli, S. enterica and Klebsiella sp. The other five namely; P. aeruginosa, E. aerogenes, P. mirabilis, S. aureus and Bacillus sp, were resistant to the extract. The sensitivity level of the three bacteria, that showed positive response where however low. Therefore, more research has to be carried out using different concentrations of the leaves extract for a more conclusive result. This concentration could permit to appreciate the degree of sensitivity and also to see if other bacteria that have not manifested any sensitivity can show some positive response to the extracts. Also, different laboratory methods and more bacteria should be used to prove that the leaves of D. mannii have the potential as a promising antibacterial medicinal plant to either render bacteria inactive or kill them completely.

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“…Specimens of the plants are deposited at the National Herbarium, Yaounde, Cameroon. Combined CH 2 Cl 2 /MeOH (1:1) extracts of Dorstenia convexa and D. barteri were obtained as previously described (14). The extraction and isolation of bartericins A, and B, stigmasterol, isobavachalcone, and 4-hydroxylonchocarpin have been previously described by Ngameni et al (14).…”

Section: Plants and Compoundsmentioning

confidence: 99%

“…Combined CH 2 Cl 2 /MeOH (1:1) extracts of Dorstenia convexa and D. barteri were obtained as previously described (14). The extraction and isolation of bartericins A, and B, stigmasterol, isobavachalcone, and 4-hydroxylonchocarpin have been previously described by Ngameni et al (14). Four hundred and fifty grams of the twigs and 210 g of the leaves were extracted with a mixture of methylene chloride and methanol (1:1) for 24 h. Dorsmanin F and 6,8-diprenyleridictyol (Table 2) were isolated from D. manni as previously described (15)(16)(17).…”

Section: Plants and Compoundsmentioning

confidence: 99%

Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa

Omisore

Adewunmi

Iwalewa

et al. 2005

Braz J Med Biol Res

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Dorstenia barteri and D. convexa extracts and some isolated components of the former were investigated for effectiveness against Trichomonas gallinarum and compared with quercetin and quercitrin. The antioxidant activity of the extracts/compounds was also determined. The minimum lethal concentrations (MLCs) for the extract of D. barteri leaves and twigs at 24 h were found to be 15.625 and 15.625 µg/ml, respectively. However, the MLCs of the leaf and twig extract of D. convexa were 125 and 437.5 µg/ml, respectively. The prenylated and geranylated chalcones were as active as the prenylated flavones, 6-prenylapigenin and the diprenylated derivative 6,8-diprenyleridictyol. The order of the antitrichomonal activity of the compounds at 24 h was: quercetin (0.121 µg/ml) > quercitrin (0.244 µg/ml) ≥ bartericin B (0.244 µg/ml) > bartericin A (0.73 µg/ml) > stigmasterol (0.98 µg/ml) > 6,8-diprenyleridictyol = isobavachalcone = dorsmanin F (31.25 µg/ ml). D. barteri extracts, quercitrin, and bartericin A, and the prenylated flavonoids had potent antioxidant properties. The twig extract of D. barteri was more potent than the leaf extract. Moderate (EC 50 >50 µg/ ml) and high (EC 50 <50 µg/ml) antioxidant activities were detected in the leaf and twig extracts of D. barteri and the prenylated flavonoids. Prenylated flavonoids and the isolated compounds with antioxidant properties described here may account for the anti-inflammatory action of these extracts. The antitrichomonal and antioxidant activities shown by the extracts and compounds in this study are consistent with the ethnomedicinal and local use of the Dorstenia species studied.

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Diprenylated chalcones and other constituents from the twigs of Dorstenia barteri var. subtriangularis

Cited by 27 publications

References 5 publications

Naturally occurring chalcones and their biological activities

Naturally occurring chalcones and their biological activities

In-vitro evaluation of the anti-bacterial properties of crude extracts of Dorstenia mannii (Moraceae)

Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa

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