Dipyridamole and postoperative ischemic deficits in aneurysmal subarachnoid hemorrhage

Shaw, M. D. M.; Foy, P. M.; Conway, Michael; Pickard, John D.; Maloney, Peter; Spillane, J. A.; Chadwick, David

doi:10.3171/jns.1985.63.5.0699

Cited by 36 publications

(21 citation statements)

References 20 publications

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“…19 -23 In 1 of these 5 trials, the sponsoring pharmaceutical company performed randomization and statistical analyses. 20 The timing of randomization and start of antiplatelet (or placebo) treatment were not uniform. Two studies randomized the patients preoperatively and started treatment before surgery.…”

Section: Description Of Trialsmentioning

confidence: 99%

“…Two studies randomized the patients preoperatively and started treatment before surgery. 19,20 In 1 study, randomization was performed preoperatively, but treatment was started only postoperatively, and actual treatment was left to the discretion of the treating neurosurgeon. 23 In 5 randomized patients in this trial, the neurosurgeon decided on the basis of the operative procedure that trial medication could not be started.…”

Section: Description Of Trialsmentioning

confidence: 99%

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Antiplatelet Therapy in Aneurysmal Subarachnoid Hemorrhage

Mees

Rinkel

Hop

et al. 2003

Stroke

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Background and Purpose-Observational studies suggest that platelet inhibitors reduce the risk of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage and thereby have a beneficial effect on clinical outcome. Robust evidence, however, is lacking. We performed a systematic meta-analysis to determine whether antiplatelet therapy has a beneficial effect after SAH. Methods-We searched Medline and the Cochrane Library to identify all randomized controlled trials of antiplatelet drugs versus control and calculated relative risks with corresponding 95% confidence intervals (CIs) for poor outcome (dependence or death), the occurrence of DCI, and the occurrence of any intracranial hemorrhage. Results-We included 5 trials totaling 699 patients. The overall relative risk for poor outcome was 0.87 (95% CI, 0.65 to

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Section: Description Of Trialsmentioning

confidence: 99%

Section: Description Of Trialsmentioning

confidence: 99%

Antiplatelet Therapy in Aneurysmal Subarachnoid Hemorrhage

Mees

Rinkel

Hop

et al. 2003

Stroke

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“…316 In two of the SAH trials, the antiplatelet trial drugs were given after the aneurysms had been surgically clipped to prevent rebleeding; 318,319 in one the antiplatelet trial drugs were definitely started before any clipping of the aneurysm; 315 and in three trials there was no indication as to whether the aneurysm had been securely treated before starting the antiplatelet trial drugs. 313,314,317 The duration of the scheduled treatment period ranged from 8 days 318 to 3 months, 315 and three studies did not clearly specify the duration of treatment. 313,314,316 The length of follow-up ranged from 1 month 42,318 to 6 months, 41,314 and one study did not specify the length of follow-up.…”

Section: Details Of the Included Trialsmentioning

confidence: 99%

“…Of the nine trials (2043 patients) of antiplatelet drugs (1997 patients) or anticoagulants (645 patients) given after acute intracranial haemorrhage that were identified, including the IST and CAST 42,[313][314][315][316][317][318][319] ( Tables 35 and 36), eight were randomised trials 41,42,[314][315][316][318][319][320] and one was a double-blind comparative study that gave no information on whether treatment allocation was randomised or not 317 . However, on balance, a decision was made to include it.…”

Section: Details Of the Included Trialsmentioning

confidence: 99%

“…321 The intracranial haemorrhage was due to SAH in six trials (1224 patients), [313][314][315],317-319 a mixture of acute intraparenchymal cerebral haemorrhage and haemorrhagic transformation of cerebral infarction in two trials (773 patients) 41,42 and proven PICH in one trial (46 patients). 316 In two of the SAH trials, the antiplatelet trial drugs were given after the aneurysms had been surgically clipped to prevent rebleeding; 318,319 in one the antiplatelet trial drugs were definitely started before any clipping of the aneurysm; 315 and in three trials there was no indication as to whether the aneurysm had been securely treated before starting the antiplatelet trial drugs. 313,314,317 The duration of the scheduled treatment period ranged from 8 days 318 to 3 months, 315 and three studies did not clearly specify the duration of treatment.…”

Section: Details Of the Included Trialsmentioning

confidence: 99%

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What is the best imaging strategy for acute stroke?

Wardlaw

Keir

Seymour

et al. 2005

Int J Technol Assess Health Care

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTAWhat is the best imaging strategy for acute stroke? NHS R&D HTA ProgrammeT he NHS R&D Health Technology Assessment (HTA) Programme was set up in 1993 to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS.Initially, six HTA panels (pharmaceuticals, acute sector, primary and community care, diagnostics and imaging, population screening, methodology) helped to set the research priorities for the HTA Programme. However, during the past few years there have been a number of changes in and around NHS R&D, such as the establishment of the National Institute for Clinical Excellence (NICE) and the creation of three new research programmes: Service Delivery and Organisation (SDO); New and Emerging Applications of Technology (NEAT); and the Methodology Programme.This has meant that the HTA panels can now focus more explicitly on health technologies ('health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care) rather than settings of care. Therefore the panel structure was replaced in 2000 by three new panels: Pharmaceuticals; Therapeutic Procedures (including devices and operations); and Diagnostic Technologies and Screening.The HTA Programme will continue to commission both primary and secondary research. The HTA Commissioning Board, supported by the National Coordinat...

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