2003
DOI: 10.1016/s0140-6736(03)12751-1
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Dipyrone and agranulocytosis: what is the risk?

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Cited by 33 publications
(22 citation statements)
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“…Metamizole is commonly preferred by many physicians in Turkey for fever unresponsive to paracetamol and ibuprofen. Although its use is banned in the United States and in several European countries because of the severe hematologic side effects, prescription is not officially restricted for children in some developing countries, including Turkey [29,30]. Rubbing children with cologne or vinegar to treat their fever are traditional home remedies in our population.…”
Section: Discussionmentioning
confidence: 99%
“…Metamizole is commonly preferred by many physicians in Turkey for fever unresponsive to paracetamol and ibuprofen. Although its use is banned in the United States and in several European countries because of the severe hematologic side effects, prescription is not officially restricted for children in some developing countries, including Turkey [29,30]. Rubbing children with cologne or vinegar to treat their fever are traditional home remedies in our population.…”
Section: Discussionmentioning
confidence: 99%
“…Since it takes about 2 weeks to trigger immune reactions in patients new to the drug, short-term studies miss the drug's dangerous effects. 10 Besides, there are case reports about severe anaphylactic reactions caused by dipyrone in the literature. [11][12][13] Dipyrone is also the analgesic that most frequently causes hypersensitivity reactions.…”
Section: Discussionmentioning
confidence: 99%
“…[9][10][11][12] Dipyrone is a derivative of phenylpyrazole prescribed at a dose of 15 mg/kg (0.6 drop/kg) and recommended for children 3 months and older. The risk of agranulocytosis and aplastic anemia, associated with dipyrone, has been extensively investigated by Schönhöfer et al 13 but remains unclear. Both drugs act after about 30 minutes, and their peak plasma concentration is reached at 2 hours after oral administration, liver metabolism and renal excretion.…”
Section: Antipyretic Effect Of Ibuprofen and Dipyrone In Febrile Chilmentioning
confidence: 99%