Dipyrrolo[1,2‐a;2′,1′‐c]pyrazines. Part 6. Electrophilic Substitution in a Series of Dipyrrolo[1,2‐a;2′,1′‐c]pyrazine and 5,6‐Dihydrodipyrrolo[1,2‐a;2′,1′‐c]pyrazine Derivatives. Phosphorylation of Dipyrrolo[1,2‐a;2′,1′‐c]pyrazines.

Abstract

2',1'-c]pyrazine and 5,6-Dihydrodipyrrolo[1,2-a;2',1'-c]pyrazine Derivatives. Phosphorylation of Dipyrrolo[1,2-a;2',1'-c]pyrazines. -The phosphorylation of the title dipyrrolopyrazine derivatives (I) with PCl3 occurs regioselectively and gives rise only to the monosubstituted products (IV). Similar phosphorylation using PBr 3 instead of PCl 3 leads to complex mixtures of both monosubstitution and disubstitution products. -(TERENIN, V. I.; SUMTSOVA, E. A.; VATSADZE, S. Z.; KABANOVA, E. V.; LESHCHEVA, I. F.; PLESHKOVA, A. P.; ZYK, N. V.; Chem. Heterocycl. Compd. (N. Y.) 39 (2003) 7, 943-952; Lomonosov Moscow State Univ., Moscow 119899, Russia; Eng.) -Staver 18-161