“…Cumene was also negative in all tested strains using modifications of the standard Ames assay, including preincubation of the culture with cumene, treating cultures in a closed chamber or sealed tubes, and using hamster liver S9 instead of rat liver S9 for metabolic activation (EC 2001;NTP 2009;Simmon et al 1977). An additional study reported that addition of cumene (10% by volume) to diesel fuel did not increase mutagenicity in S. typhimurium (strains not specified) (Jensen et al 1988).…”
Section: In Vitro Studies In Bacteria and Yeastmentioning
Led the preparation of the cancer hazard evaluation, including the design, conduct, and assessment of studies, the technical review, and the proposed cancer hazard conclusions
“…Cumene was also negative in all tested strains using modifications of the standard Ames assay, including preincubation of the culture with cumene, treating cultures in a closed chamber or sealed tubes, and using hamster liver S9 instead of rat liver S9 for metabolic activation (EC 2001;NTP 2009;Simmon et al 1977). An additional study reported that addition of cumene (10% by volume) to diesel fuel did not increase mutagenicity in S. typhimurium (strains not specified) (Jensen et al 1988).…”
Section: In Vitro Studies In Bacteria and Yeastmentioning
Led the preparation of the cancer hazard evaluation, including the design, conduct, and assessment of studies, the technical review, and the proposed cancer hazard conclusions
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