Direct afferent excitation and long-term potentiation of hippocampal interneurons.

Buzsáki, G; Eidelberg, E.

doi:10.1152/jn.1982.48.3.597

Cited by 236 publications

(131 citation statements)

References 0 publications

Supporting

Mentioning

121

Contrasting

Order By: Relevance

“…In addition, interneurons are characterized by a large afterhyperpolarization following action potentials, weak spike frequency adaptation, and short time constants (Schwartzkroin and Mathers, 1978;McCormick et al, 1985;Lacaille et al, 1987;Lacaille and Schwartzkroin, 1988;Lacaille and Williams, 1990;Scharfman, 1992b). Studies in vivo and in vitro have shown that they often have low thresholds for synaptic activation (Buzsáki and Eidelberg, 1981;Scharfman, 1991). However, some variability has been described, both in area CA1 and elsewhere Hama, 1987b, 1990;Lacaille et al, 1989;Scharfman, 1992b;Han, 1994).…”

Section: Intrinsic Properties and Patterns Of Dischargementioning

confidence: 99%

See 1 more Smart Citation

Electrophysiological diversity of pyramidal‐shaped neurons at the granule cell layer/hilus border of the rat dentate gyrus recorded in vitro

Scharfman

1995

Hippocampus

View full text Add to dashboard Cite

In the rat dentate gyrus, pyramidal-shaped cells located on the border of the granule cell layer and the hilus are one of the most common types of γ-aminobutyric acid (GABA)-immunoreactive neurons. This study describes their electrophysiological characteristics. Membrane properties, patterns of discharge, and synaptic responses were recorded intracellularly from these cells in hippocampal slices. Each cell was identified as pyramidal-shaped by injecting the marker Neurobiotin intracellularly (n = 17).In several respects the membrane properties of the sampled cells were similar to "fast-spiking" cells (putative inhibitory interneurons) that have been described in other areas of the hippocampus. For example, input resistance was high (mean 91.3 megohms), the membrane time constant was short (mean 7.7 ms), and there was a large afterhyperpolarization following a single action potential (mean 10.5 mV at resting potential). However, the action potentials of most pyramidalshaped cells were not as brief (mean 1.2 ms total duration) as those of most previously described fast-spiking cells. Many pyramidal-shaped neurons had strong spike frequency adaptation relative to other fast-spiking cells. Although these latter two characteristics were apparent in the majority of the sampled cells, there were exceptional pyramidal-shaped neurons with fast action potentials and weak adaptation, demonstrating the electrophysiological variability of pyramidal-shaped cells.Responses to outer molecular layer stimulation were composed primarily of excitatory postsynaptic potentials (EPSPs) rather than inhibitory postsynaptic potentials (IPSPs), and were usually small (EPSPs evoked at threshold were often less than 2 mV), and brief (less than 30 ms). There was variability, because in a few cells EPSPs evoked at threshold were much larger. However, regardless of EPSP amplitude, suprathreshold stimulation (up to 4 times the threshold stimulus strength) rarely evoked more than one action potential in any cell. The results suggest that stimulation of perforant path axons produces limited excitatory synaptic responses in pyramidal-shaped neurons. This may be one of the reasons why they are relatively resistant to prolonged perforant path stimulation.The pyramidal-shaped neurons located at the base of the granule cell layer have been associated historically with a basket plexus around granule cell somata, and have been called pyramidal "basket" cells. However, basket-like endings were rare and axon collaterals outside the granule cell layer were common. Many axon collaterals were as far from the granule cell layer as the outer molecular layer and the central hilus, and antidromic action potentials could be recorded in some

show abstract

Section: Intrinsic Properties and Patterns Of Dischargementioning

confidence: 99%

“…However, the latency to onset of EPSPs was not different from latencies of granule cell EPSPs. Therefore, it is unclear at the present time whether the pyramidal-shaped cells arc feedforward or feedback interneurons, as has been hypothesized (Andersen ct al., 1963;Blackstad and Flood, 1963;Buzsáki and Eidelberg, 1981).…”

Section: Types Of Responsesmentioning

confidence: 99%

Electrophysiological diversity of pyramidal‐shaped neurons at the granule cell layer/hilus border of the rat dentate gyrus recorded in vitro

Scharfman

1995

Hippocampus

View full text Add to dashboard Cite

show abstract

“…At least 3 different factors might contribute to these effects. One is that perforant path synapses onto inhibitory intemeurons also increase in strength (Buzsaki and Eidelberg, 1982;Kairiss et al, 1987;Taube and Schwartzkroin, 1987) and that this increase is more persistent than that which occurs on granule cells. The resulting increase in feedforward inhibition ofgranule cells could account for the reduced Effects on Dentate Evoked Responses spike.…”

Section: General Hypothesismentioning

confidence: 99%

Exploration-dependent modulation of evoked responses in fascia dentata: dissociation of motor, EEG, and sensory factors and evidence for a synaptic efficacy change

1990

View full text Add to dashboard Cite

“…Far less is known about modifications of inhibitory synapses under similar conditions of activity, although inhibitory inputs play a crucial role in shaping the activity of neuronal networks (Cobb et al, 1995;Freund and Buzsaki, 1996;reviewed in Freund, 2003;Klausberger and Somogyi, 2008). Long-term changes of interneuron discharge and of inhibitory transmission associated with increased synaptic activity have been reported at various inhibitory synapses (Buzsaki and Eidelberg, 1982;Gaiarsa et al, 2002;Kullmann and Lamsa, 2007;Klausberger and Somogyi, 2008;Pelletier and Lacaille, 2008;McBain and Kauer, 2009;Nissen et al, 2010). The cellular and molecular mechanisms underlying these phenomena are however still poorly understood and rely on both pre-and postsynaptic modifications depending on the synapses under study.…”

Section: Introductionmentioning

confidence: 99%

Excitatory synaptic activity is associated with a rapid structural plasticity of inhibitory synapses on hippocampal CA1 pyramidal cells

et al. 2011

View full text Add to dashboard Cite

This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. Synaptic activity, such as long-term potentiation (LTP), has been shown to induce morphological plasticity of excitatory synapses on dendritic spines through the spine head and postsynaptic density (PSD) enlargement and reorganization. Much less, however, is known about activity-induced morphological modifications of inhibitory synapses. Using an in vitro model of rat organotypic hippocampal slice cultures and electron microscopy, we studied activity-related morphological changes of somatic inhibitory inputs triggered by a brief oxygeneglucose deprivation (OGD) episode, a condition associated with a synaptic enhancement referred to as anoxic LTP and a structural remodeling of excitatory synapses. Threedimensional reconstruction of inhibitory axo-somatic synapses at different times before and after brief OGD revealed important morphological changes. The PSD area significantly and markedly increased at synapses with large and complex PSDs, but not at synapses with simple, macular PSDs. Activity-related changes of PSD size and presynaptic bouton volume developed in a strongly correlated manner. Analyses of single and serial sections further showed that the density of inhibitory synaptic contacts on the cell soma did not change within 1 h after OGD. In contrast, the proportion of the cell surface covered with inhibitory PSDs, as well as the complexity of these PSDs significantly increased, with less macular PSDs and more complex, segmented shapes. Together, these data reveal a rapid activity-related restructuring of somatic inhibitory synapses characterized by an enlargement and increased complexity of inhibitory PSDs, providing a new mechanism for a quick adjustment of the excitatoryeinhibitory balance. This article is part of a Special Issue entitled 'Synaptic Plasticity & Interneurons'.

show abstract

Direct afferent excitation and long-term potentiation of hippocampal interneurons.

Cited by 236 publications

References 0 publications

Electrophysiological diversity of pyramidal‐shaped neurons at the granule cell layer/hilus border of the rat dentate gyrus recorded in vitro

Electrophysiological diversity of pyramidal‐shaped neurons at the granule cell layer/hilus border of the rat dentate gyrus recorded in vitro

Exploration-dependent modulation of evoked responses in fascia dentata: dissociation of motor, EEG, and sensory factors and evidence for a synaptic efficacy change

Excitatory synaptic activity is associated with a rapid structural plasticity of inhibitory synapses on hippocampal CA1 pyramidal cells

Contact Info

Product

Resources

About