Direct Analysis of HIV mRNA m6A Methylation by Nanopore Sequencing

Honeycutt, Ethan; Kizito, Fredrick; Karn, Jonathan; Sweet, Thomas

doi:10.1007/978-1-0716-3862-0_15

Methods in Molecular Biology

2024

DOI: 10.1007/978-1-0716-3862-0_15

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Direct Analysis of HIV mRNA m6A Methylation by Nanopore Sequencing

Ethan Honeycutt,

Fredrick Kizito,

Jonathan Karn

et al.

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When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse?

Wang,

Jin,

Xie

et al. 2024

Vet Res

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N6-methyladenosine (m6A) is a prevalent and dynamic RNA modification, critical in regulating gene expression. Recent research has shed light on its significance in the life cycle of viruses, especially animal viruses. Depending on the context, these modifications can either enhance or inhibit the replication of viruses. However, research on m6A modifications in animal virus genomes and the impact of viral infection on the host cell m6A landscape has been hindered due to the difficulty of detecting m6A sites at a single-nucleotide level. This article summarises the methods for detecting m6A in RNA. It then discusses the progress of research into m6A modification within animal viruses’ infections, such as influenza A virus, porcine epidemic diarrhoea virus, porcine reproductive, and respiratory syndrome virus. Finally, the review explores how m6A modification affects the following three aspects of the replication of animal RNA viruses: the regulation of viral genomic RNA function, the alteration of the m6A landscape in cells after viral infection, and the modulation of antiviral immunity through m6A modification. Research on m6A modifications in viral RNA sheds light on virus-host interactions at a molecular level. Understanding the impact of m6A on viral replication can help identify new targets for antiviral drug development and may uncover novel regulatory pathways that could potentially enhance antiviral immune responses.

show abstract

When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse?

Wang,

Jin,

Xie

et al. 2024

Vet Res

View full text Add to dashboard Cite

show abstract

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Direct Analysis of HIV mRNA m6A Methylation by Nanopore Sequencing

Cited by 1 publication

References 48 publications

When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse?

When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse?

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