Direct analysis of indomethacin in rat plasma using a column-switching high-performance liquid chromatographic system

Automated analysis of fluvoxamine in rat plasma using a column‐switching system and ion‐pair high‐performance liquid chromatography

“…in-stream can improve the resolution by using different stationary phases or mobile phases and keeping on-line enrichment and sample clean-up in the same analytical system (Liu et al, 2002).…”

Cubosome Dispersions as Delivery Systems for Percutaneous Administration of Indomethacin

“…Chromatography was performed following a slight modification of the method reported by Liu et al (30). Elution was conducted with a mobile phase constituted of water (pH 3 adjusted with phosphoric acid) and acetonitrile 30:70 v/v, with a flow rate of 1 ml/min.…”

Simple determination of terbutaline in dog plasma by column-switching liquid chromatography

“…The dogs were provided a standardised meal 6 h after drug intake. Blood samples of control group were collected into heparinised polystyrene tubes at time 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 7, 9, 11 and 15 h. Blood samples of test group were collected at time 0, 2, 2.5, 3,4,5,7,8,9,11,12,14,15,18,19,23, 26 and 28 h. Plasma samples were obtained from the supernatant of centrifuged blood and they were immediately frozen and kept at −20 • C until assay. There was a 1-week washing-out time between each treatment period.…”

“…The limit of detection for this method defined as a signal-to-noise ratio of 3:1, was 1.5 ng/ml. The limit of quantification (LOQ) was defined as the lowest drug concentration, which can be determined with a within-day relative standard deviation R.S.D.≤20% [14,15]. The LOQ was estimated as 3 ng/ml.…”