Direct analysis of traditional Chinese medicines by mass spectrometry

Wong, Melody Yee-Man; So, Pui‐Kin; Yao, Zhongping

doi:10.1016/j.jchromb.2015.11.032

Cited by 24 publications

(19 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of the applications have been summarized in recently published review articles [26][27][28][29]. Here we further discuss the large field of ambient ionization techniques that have been published for analysis of pharmaceutical products and herbal medicines to date (Table 1), with analytical strategies emphasized.…”

Section: Ambient Ionization Techniques Applied For Analysis Of Pharmamentioning

confidence: 99%

Analysis of pharmaceutical products and herbal medicines using ambient mass spectrometry

Yang

Deng

2016

TrAC Trends in Analytical Chemistry

View full text Add to dashboard Cite

Section: Ambient Ionization Techniques Applied For Analysis Of Pharmamentioning

confidence: 99%

Analysis of pharmaceutical products and herbal medicines using ambient mass spectrometry

Yang

Deng

2016

TrAC Trends in Analytical Chemistry

View full text Add to dashboard Cite

“…To ensure the reliability and repeatability of pharmacological research, to understand the bioactivities of medicines, and to enhance product quality control, the whole profiles of herbal medicines need to be determined . Currently, modern chemical, physical, and biological analysis methods are used as common fingerprinting methods in TCM, such as thin‐layer chromatography (TLC), high‐performance liquid chromatography (HPLC), high‐speed counter‐current chromatography (HSCCC), gas chromatography (GC), ultraviolet spectroscopy (UV), Fourier transform infrared spectroscopy (FTIR), near infrared spectroscopy (NIR), mass spectroscopy (MS), nuclear magnetic resonance spectroscopy (NMR), X‐ray diffraction, capillary electrophoresis (CE), and DNA techniques …”

Section: Introductionmentioning

confidence: 99%

Geographic origin identification and rapid determination of four constituents of Gentiana rigescens by FTIR combined with chemometrics

Zhao

Tianjun

Zhang

et al. 2019

Journal of Chemometrics

View full text Add to dashboard Cite

Gentiana rigescens is one of the most important traditional Chinese medicines because of its therapeutic effects in protecting the liver and promoting bile discharge, anti‐hypertension, and spasm and pain relief. To enhance quality control, a comprehensive assessment of G. rigescens from different geographic origins by Fourier‐transform infrared (FTIR) in combination with chemometrics was conducted. Through pretreatment by the second derivative, spectrum standard deviation and Monte Carlo uninformative variable elimination (MC‐UVE), the characteristic FTIR spectra were selected and an identification model of the different geographic origins of G. rigescens was built by partial least squares discriminant analysis (PLS‐DA). The validation results showed that the accuracy rates of the model were 100%, 97.22%, and 100% for samples from Yunnan, Guizhou, and Sichuan, respectively. On the basis of the correlation between characteristic spectral points and the contents of swertiamarin, gentiopicroside, sweroside, and loganic acid, quantitative models were established by partial least squares regression (PLSR). The measured and predicted values were not significantly different as assessed through the paired t test (p > 0.05). Additionally, the characteristic spectra were interpreted, and 93 common peaks were selected. FTIR analysis combined with chemometric methods could accurately identify the different geographic origins of G. rigescens and rapidly predict the content of swertiamarin, gentiopicroside, sweroside, and loganic acid, thus providing a comprehensive method of evaluating traditional Chinese medicines.

show abstract

“…Herbal medicines have been used to prevent and treat diseases for thousands of years because of their high efficacy, low toxicity, and low costs . However, herbal medicines are complex mixtures with many components , making the extraction of active compounds very time‐consuming and labor‐intensive isolation. Some methods were applied such as ultrafiltration with LC–MS.…”

Section: Introductionmentioning

confidence: 99%

Efficient discovery and capture of new neuronal nitric oxide synthase–postsynaptic density protein‐95 uncouplers from herbal medicines using magnetic molecularly imprinted polymers as artificial antibodies

Huang

Zhang

et al. 2017

J of Separation Science

View full text Add to dashboard Cite

In the scope of stroke treatment, new neuronal nitric oxide synthase-postsynaptic density protein-95 uncouplers from herbal medicines were discovered and captured. To do so, highly selective magnetic molecularly imprinted polymers with a core-shell structure were prepared as artificial antibodies. According to the results of computational simulations, we designed and synthesized various polymers with varying amounts and types of template, functional monomer, cross-linker, and solvent. Characterization and performance tests revealed that the most appropriate artificial antibodies showed uniform spherical morphologies, large adsorption capacities, fast-binding kinetics, high selectivity, and quick separation. These artificial antibodies were then used as sorbents for dispersive magnetic solid-phase extraction coupled with high-performance liquid chromatography and mass spectrometry to capture and identify structural analogs to ZL006 from extracts of Scutellariae radix, Psoraleae fructus, and Trifolium pratense. Furthermore, according to the neuroprotective effect and coimmunoprecipitation test, Baicalein, Neobavaisoflavone, Corylifol A, and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. Therefore, this present study contributes valuable information for the discovery of neuronal nitric oxide synthase-postsynaptic density protein-95 uncouplers from herbal medicines.

show abstract

Direct analysis of traditional Chinese medicines by mass spectrometry

Cited by 24 publications

References 95 publications

Analysis of pharmaceutical products and herbal medicines using ambient mass spectrometry

Analysis of pharmaceutical products and herbal medicines using ambient mass spectrometry

Geographic origin identification and rapid determination of four constituents of Gentiana rigescens by FTIR combined with chemometrics

Efficient discovery and capture of new neuronal nitric oxide synthase–postsynaptic density protein‐95 uncouplers from herbal medicines using magnetic molecularly imprinted polymers as artificial antibodies

Contact Info

Product

Resources

About