Direct and crossed effects of somatosensory stimulation on neuronal excitability and motor performance in humans

Veldman, Menno P.; Maffiuletti, Nicola A.; Hallett, Mark; Zijdewind, Inge; Hortobágyi, Tibor

doi:10.1016/j.neubiorev.2014.07.013

Cited by 72 publications

(75 citation statements)

References 181 publications

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“…Indeed, both NMES protocols elicited brain activation within a wide network of cortical and subcortical structures close to that activated during repeated isometric voluntary contractions. It has been previously shown that increased sensory input can improve motor function and learning by increasing the excitability of the neuronal path projecting to muscles and joints wherein the sensory receptors are activated 63 . One could therefore speculate that the two NMES protocols might induce a specific brain plasticity due to the differences in the magnitude of sensory inputs to the brain.…”

Section: Discussionmentioning

confidence: 99%

Specific brain activation patterns associated with two neuromuscular electrical stimulation protocols

Wegrzyk

Ranjeva

Fouré

et al. 2017

Sci Rep

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The influence of neuromuscular electrical stimulation (NMES) parameters on brain activation has been scarcely investigated. We aimed at comparing two frequently used NMES protocols - designed to vary in the extent of sensory input. Whole-brain functional magnetic resonance imaging was performed in sixteen healthy subjects during wide-pulse high-frequency (WPHF, 100 Hz–1 ms) and conventional (CONV, 25 Hz–0.05 ms) NMES applied over the triceps surae. Each protocol included 20 isometric contractions performed at 10% of maximal force. Voluntary plantar flexions (VOL) were performed as control trial. Mean force was not different among the three protocols, however, total current charge was higher for WPHF than for CONV. All protocols elicited significant activations of the sensorimotor network, cerebellum and thalamus. WPHF resulted in lower deactivation in the secondary somatosensory cortex and precuneus. Bilateral thalami and caudate nuclei were hyperactivated for CONV. The modulation of the NMES parameters resulted in differently activated/deactivated regions related to total current charge of the stimulation but not to mean force. By targeting different cerebral brain regions, the two NMES protocols might allow for individually-designed rehabilitation training in patients who can no longer execute voluntary movements.

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Section: Discussionmentioning

confidence: 99%

Specific brain activation patterns associated with two neuromuscular electrical stimulation protocols

Wegrzyk

Ranjeva

Fouré

et al. 2017

Sci Rep

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“…Transcutaneous electrical nerve stimulation (TENS) on the median nerve induced SEPs, resulting in delayed gating effects on cortical response (Torquati et al, 2007). TENS also broadly modulated sensorimotor brain network activity, including the somatosensory cortex, basal ganglia, and thalamus (Choi et al, 2016;Dhond et al, 2008;Fang et al, 2009;Kara et al, 2010), and cortical neuronal excitability (Veldman et al, 2014). It appears that TENS, in particular TEAS, is capable of repairing filtering' dysfunction of the sensorimotor gating via enhancing 5-HT and neuropeptide functions in related brain regions.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Transcutaneous electrical acupoint stimulation as an adjunct therapy for obsessive-compulsive disorder: A randomized controlled study

Feng

Zhang

Zhu

et al. 2016

Journal of Psychiatric Research

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Background: Transcutaneous electrical acupoint stimulation (TEAS) is thought to have potential to treat obsessive-compulsive disorder (OCD).Objective: The purpose of this study was to determine whether adding TEAS to cognitive behavioral therapy (CBT) and clomipramine would improve the efficacy of these conventional treatments in OCD.Methods: In this randomized controlled trial, 360 OCD patients were assigned to receive TEAS combined with CBT plus clomipramine (Group A, n = 120), TEAS combined with CBT plus placebo (Group B, n = 120), and simulated (placebo) TEAS combined with CBT plus clomipramine (Group C, n = 120) for 12 weeks. The primary outcome was measured using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS).Results: OCD symptoms in all patients reduced over time, however Groups A and B had a significantly greater reduction in Y-BOCS total score and the subscale for obsession and compulsion between week 2 and week 12 compared to Group C. Groups A and B had similar scores on these measures. Both groups had significantly higher rates of clinical response than Group C (88.3% and 81.7% vs. 67.5%, respectively, p < 0.001); and higher rates of remission (30.0% and 22.5% vs. 9.2%, respectively, p < 0.001).Group B experienced fewer adverse events than the other two groups.Conclusions: TEAS enhances the efficacy of conventional OCD interventions and avoids the adverse effects associated with conventional pharmacological treatment. It can be considered as an effective adjunct intervention for OCD.

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“…Therefore, although it may be recognized that such mechanisms are determined at two levels of the CNS, SES might produce modulatory effects at the cortical level [27]. According to Veldman et al [28], we also suggest that the level and direction of SES effects on M1 excitability depend particularly on the stimulation intensity, which may vary considerably. This means that depending on the step increment in SES intensity from the perceptual threshold, M1 excitability may vary between depression and facilitation.…”

Section: Discussionmentioning

confidence: 49%

Can somatosensory electrical stimulation relieve spasticity in post-stroke patients? A TMS pilot study

Peres

Souza

Catunda

et al. 2017

Biomedical Engineering / Biomedizinische Technik

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Evidence suggests that somatosensory electrical stimulation (SES) may decrease the degree of spasticity from neural drives, although there is no agreement between corticospinal modulation and the level of spasticity. Thus, stroke patients and healthy subjects were submitted to SES (3 Hz) for 30′ on the impaired and dominant forearms, respectively. Motor evoked potentials induced by single-pulse transcranial magnetic stimulation were collected from two forearm muscles before and after SES. The passive resistance of the wrist joint was measured with an isokinetic system. We found no evidence of an acute carryover effect of SES on the degree of spasticity.

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Direct and crossed effects of somatosensory stimulation on neuronal excitability and motor performance in humans

Cited by 72 publications

References 181 publications

Specific brain activation patterns associated with two neuromuscular electrical stimulation protocols

Specific brain activation patterns associated with two neuromuscular electrical stimulation protocols

Transcutaneous electrical acupoint stimulation as an adjunct therapy for obsessive-compulsive disorder: A randomized controlled study

Can somatosensory electrical stimulation relieve spasticity in post-stroke patients? A TMS pilot study

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