Direct and crossover effects of brinzolamide, betaxolol, and latanoprost on choroidal thickness

Okutucu, Murat; Fındık, Hüseyin; Arslan, Mehmet Gökhan

doi:10.1080/15569527.2019.1575390

Cited by 11 publications

(11 citation statements)

References 26 publications

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“…Exclusion: Patients with documented previous ocular disease (glaucoma, diabetic retinopathy, macular degeneration high myopia exceeding -6.0 diopters with other than uncomplicated cataract surgery Macular-off RRD Received more than one surgery repaired With PVR grade 3 or 4 and eceived retinotomy with choroidal detachment Intraocular pressure greater than 21 mmHg Considering intraocular pressure [ 12 ] and antiglaucomatous drops [ 13 ] had a significant effect on SFCT, we excluded the patients postoperative intraocular pressure more than 21 mmHg. …”

Section: Methodsmentioning

confidence: 99%

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Effects of refractive accommodation on subfoveal choroidal thickness in silicone oil-filled eyes

et al. 2022

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Purpose To investigate the effects of refractive accommodation on subfoveal choroidal thickness (SFCT) in silicone oil (SO)-filled eyes. Methods This retrospective, self-comparative study was conducted on 40 patients with unilateral macula-on rhegmatogenous retinal detachment, who underwent vitrectomy and SO tamponade. The SFCT of SO-filled eyes and the fellow control eyes were measured using optical coherence tomography at their one-month visit after surgery. The patients wore soft contact positive lenses for 24 h in the SO-filled eyes, to correct their refractive error. SFCT and choroidal vascularity index (CVI) were measured before and after wearing the contact lenses. Mean SFCT was compared between SO-filled eyes and the fellow control eyes, and SFCT and CVI were compared before and after refractive error correction in the SO-filled eyes. Results Mean SFCT of SO-filled eyes (221.52 ± 38.41 um) was less than that of the fellow eyes (273.41 ± 31.30 um) (P < 0.001). After refractive error correction, the mean SFCT increased to 269.28 ± 36.90 um(P < 0.001). However, CVI decreased from 57.01 ± 2.41 to 55.39 ± 2.39 (P < 0.05). Conclusions SFCT reduction in SO-filled eyes was primarily due to the hyperopia status. The non-uniform change in CVI suggests that changes in CT are mainly attributed to a greater expansion of the stromal area instead of the choroidal vascular area. Trial registration This study protocol was reviewed and approved by the Ethics Committee of the Central Theater General Hospital, approval number No. [2020]058–1, retrospectively registered.

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Section: Methodsmentioning

confidence: 99%

“…Considering intraocular pressure [ 12 ] and antiglaucomatous drops [ 13 ] had a significant effect on SFCT, we excluded the patients postoperative intraocular pressure more than 21 mmHg.…”

Section: Methodsmentioning

confidence: 99%

Effects of refractive accommodation on subfoveal choroidal thickness in silicone oil-filled eyes

et al. 2022

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“…The drug exerted no statistically significant effect on the pulse rate [14]. Brinzolamide and betaxolol significantly increased the thickness of choroidal in healthy individuals, while latanoprost had no effect [15]. With regard to the undesirable effects of beta blockers, a study by the authors who monitored 1112 patients with the diagnosis of AV block should be stated.…”

Section: Progression Of Changes In Visual Fields (Md) For Latanoprost Wasmentioning

confidence: 98%

Changes in Visual Fields in Normotensive Glaucoma

Hofschneider¹,

Lešták²,

Pitrová

2019

BJSTR

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To find the effect of prostaglandins and beta blockers on medium-term progression of changes of visual fields in normotensive glaucoma in a retrospective study. We evaluated three groups of patients with normotensive glaucoma (NTG). The first group consisted of 28 eyes of 14 patients (8 females and 6 males) of mean age 59 years (37-75 years) who were treated with prostaglandins. The second group consisted of 20 eyes of 10 patients (5 females and 5 males) of mean age 64 years (52-79 years) who were treated with beta blockers. The third group consisted of 36 eyes of 18 patients (8 females and 10 males) of mean age 57 years (33-75 years) who underwent no ophthalmological therapy. All patients were compensated for cardiovascular status and had no other internal or neurological disease. Visual acuity was 1.0 with a possible correction (less than 3 dioptres) in all patients.If hypotensive ophthalmological therapy was initiated, it had remained stable for the last five years. In all patients, central corneal thickness (CCT), excavation of the optic nerve papilla (c/d), ganglion cell complex (GCC), retinal nerve fiber thickness (RNFL), pupillary defect (PD) and overall defect (OD) of visual field were monitored by us. Statistical analysis found the highest progression of changes in the visual fields (PD) in patients without therapy (p=0.0001) and in patients treated with prostaglandins (p=0.04). In patients who were treated with beta blockers, the progression of changes in the visual fields was statistically significant (p=0.7). We did not find a statistically significant progression in any group. The correlation analysis found the highest correlation with GCC in PD (r=0.33; p=0.44). We did not find any correlation between the evaluated parameters in OD. Our results show that therapy with beta blockers is more convenient for NTG, compared to prostaglandins or no topical therapy. All patients were compensated for cardiovascular status and had no

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“…The intraocular pressure (IOP)-lowering therapies described in this review, with the exception of mannitol, are often administered chronically. A number of agents used to lower IOP are associated with increased CT. 10,11,56 Medications whose proposed predominant mechanism of action is to decrease aqueous humour production include β-adrenergic antagonists, carbonic anhydrase inhibitors, and α receptor agonists (in their first month of use). Topical β-adrenergic antagonists and carbonic anhydrase inhibitor combination agents (e.g.…”

Section: Intraocular Pressure-lowering Therapiesmentioning

confidence: 99%

The effect of systemic and topical ophthalmic medications on choroidal thickness: A review

Yeung

Park

et al. 2022

Brit J Clinical Pharma

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The choroid plays an important role in various ocular pathologies and retinal blood supply. There is a knowledge gap on how the choroid is affected by systemic and topical medications. Systemic medications that affect microvasculature elsewhere in the body can also affect the microvasculature of the choroid. This review summarizes current knowledge on associations between systemic and topical medications and changes in choroidal thickness (CT). This review included 71 studies on mydriatics/cycloplegics, intraocular pressure (IOP)‐lowering therapies, antihypertensives, adrenergic antagonists, statins, corticosteroids, hydroxychloroquine, isotretinoin, hormonal contraceptives, phosphodiesterase inhibitors, antipsychotics, antineoplastic agents, ethanol, caffeine and nicotine. IOP‐lowering therapies, atropine eye drops, and systemic administration of β blockers and ethanol are associated with a significant increase in CT. Cyclopentolate and phenylephrine are associated with a CT reduction. Systemic medications that decrease CT include caffeine and nicotine. Tropicamide, angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers, statins, corticosteroids, hydroxychloroquine and hormonal contraceptives have mixed findings. CT increase associated with IOP‐lowering therapies is possibly achieved by enhancing aqueous humour flow to the choroid thus elevating choroidal blood flow and thickness. CT changes appear to be independent from systemic blood pressure changes, suggesting that a significant association with an antihypertensive could be due to an idiosyncratic drug property. Statins and candesartan decrease macrophage accumulation and intercellular adhesion molecule 1 expression in the choroid. The choroid and its response to various disease processes and systemic medication can be further investigated to improve patient care, particularly in patients with choroid and retina pathologies.

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Direct and crossover effects of brinzolamide, betaxolol, and latanoprost on choroidal thickness

Cited by 11 publications

References 26 publications

Effects of refractive accommodation on subfoveal choroidal thickness in silicone oil-filled eyes

Effects of refractive accommodation on subfoveal choroidal thickness in silicone oil-filled eyes

Changes in Visual Fields in Normotensive Glaucoma

The effect of systemic and topical ophthalmic medications on choroidal thickness: A review

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